1OEC

FGFr2 kinase domain

Summary for 1OEC

• Entry DOI: 10.2210/pdb1oec/pdb
• Related: 1DJS 1E0O 1EV2 1GJO 1II4 1IIL
• Descriptor: FIBROBLAST GROWTH FACTOR RECEPTOR 2, SULFATE ION, 4-ARYL-2-PHENYLAMINO PYRIMIDINE, ... (4 entities in total)
• Functional Keywords: transferase, fgfr2 kinase domain, receptor tyrosine kinase
• Biological source: HOMO SAPIENS (HUMAN)
• Cellular location: Cell membrane; Single-pass type I membrane protein. Isoform 14: Secreted. Isoform 19: Secreted: P21802
• Total number of polymer chains: 1
• Total formula weight: 36740.70

Authors

Ceska, T.A.,Owens, R.,Doyle, C.,Hamlyn, P.,Crabbe, T.,Moffat, D.,Davis, J.,Martin, R.,Perry, M.J. (deposition date: 2003-03-24, release date: 2004-10-27, Last modification date: 2023-12-13)

• Primary citation: Ceska, T.A.,Owens, R.,Doyle, C.,Hamlyn, P.,Crabbe, T.,Moffat, D.,Davis, J.,Martin, R.,Perry, M.J.; The Crystal Structure of the Fgfr2 Tyrosine Kinase Domain in Complex with 4-Aryl-2-Phenylamino Pyrimidine Angiogenesis Inhibitors; To be Published,

Experimental method

X-RAY DIFFRACTION (2.4 Å)