1IIL
CRYSTAL STRUCTURE OF PRO253ARG APERT MUTANT FGF RECEPTOR 2 (FGFR2) IN COMPLEX WITH FGF2
Summary for 1IIL
Entry DOI | 10.2210/pdb1iil/pdb |
Related | 1EV2 1II4 |
Descriptor | HEPARIN-BINDING GROWTH FACTOR 2, FIBROBLAST GROWTH FACTOR RECEPTOR 2 (3 entities in total) |
Functional Keywords | immunoglobulin like domain, b-trefoil, growth factor-growth factor receptor complex, growth factor/growth factor receptor |
Biological source | Homo sapiens (human) More |
Cellular location | Cell membrane; Single-pass type I membrane protein. Isoform 14: Secreted. Isoform 19: Secreted: P21802 |
Total number of polymer chains | 8 |
Total formula weight | 167802.98 |
Authors | Ibrahimi, O.A.,Eliseenkova, A.V.,Plotnikov, A.N.,Ornitz, D.M.,Mohammadi, M. (deposition date: 2001-04-23, release date: 2001-05-09, Last modification date: 2023-08-16) |
Primary citation | Ibrahimi, O.A.,Eliseenkova, A.V.,Plotnikov, A.N.,Yu, K.,Ornitz, D.M.,Mohammadi, M. Structural basis for fibroblast growth factor receptor 2 activation in Apert syndrome. Proc.Natl.Acad.Sci.USA, 98:7182-7187, 2001 Cited by PubMed: 11390973DOI: 10.1073/pnas.121183798 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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