1EV2

CRYSTAL STRUCTURE OF FGF2 IN COMPLEX WITH THE EXTRACELLULAR LIGAND BINDING DOMAIN OF FGF RECEPTOR 2 (FGFR2)

Summary for 1EV2

Entry DOI	10.2210/pdb1ev2/pdb
Related	1CVS 1EVT
Descriptor	PROTEIN (FIBROBLAST GROWTH FACTOR 2), PROTEIN (FIBROBLAST GROWTH FACTOR RECEPTOR 2), SULFATE ION, ... (4 entities in total)
Functional Keywords	immunoglobulin (ig)like domains belonging to the i-set subgroup within ig-like domains, b-trefoil fold, growth factor-growth factor receptor complex, growth factor/growth factor receptor
Biological source	Homo sapiens (human) More
Cellular location	Cell membrane; Single-pass type I membrane protein. Isoform 14: Secreted. Isoform 19: Secreted: P21802
Total number of polymer chains	8
Total formula weight	159389.34
Authors	Plotnikov, A.N.,Hubbard, S.R.,Schlessinger, J.,Mohammadi, M. (deposition date: 2000-04-19, release date: 2000-05-31, Last modification date: 2021-11-03)
Primary citation	Plotnikov, A.N.,Hubbard, S.R.,Schlessinger, J.,Mohammadi, M. Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity. Cell(Cambridge,Mass.), 101:413-424, 2000 Cited by PubMed: 10830168 DOI: 10.1016/S0092-8674(00)80851-X PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation