1CVS

CRYSTAL STRUCTURE OF A DIMERIC FGF2-FGFR1 COMPLEX

Summary for 1CVS

Entry DOI	10.2210/pdb1cvs/pdb
Descriptor	FIBROBLAST GROWTH FACTOR 2, FIBROBLAST GROWTH FACTOR RECEPTOR 1, SULFATE ION (3 entities in total)
Functional Keywords	fgf, fgfr, immunoglobulin-like, signal transduction, dimerization, growth factor-growth factor receptor complex, growth factor/growth factor receptor
Biological source	Homo sapiens (human) More
Cellular location	Membrane; Single-pass type I membrane protein: P11362
Total number of polymer chains	4
Total formula weight	81154.54
Authors	Plotnikov, A.N.,Schlessinger, J.,Hubbard, S.R.,Mohammadi, M. (deposition date: 1999-08-24, release date: 2000-01-28, Last modification date: 2024-04-03)
Primary citation	Plotnikov, A.N.,Schlessinger, J.,Hubbard, S.R.,Mohammadi, M. Structural basis for FGF receptor dimerization and activation. Cell(Cambridge,Mass.), 98:641-650, 1999 Cited by PubMed: 10490103 DOI: 10.1016/S0092-8674(00)80051-3 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation