1IIL
CRYSTAL STRUCTURE OF PRO253ARG APERT MUTANT FGF RECEPTOR 2 (FGFR2) IN COMPLEX WITH FGF2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D | HEPARIN-BINDING GROWTH FACTOR 2 | polymer | 155 | 17249.7 | 4 | UniProt (P09038) Pfam (PF00167) In PDB | Homo sapiens (human) | FGF2, HBGF-2, BASIC FIBROBLAST GROWTH FACTOR, BFGF |
| 2 | E, F, G, H | FIBROBLAST GROWTH FACTOR RECEPTOR 2 | polymer | 220 | 24701.0 | 4 | UniProt (P21802) Pfam (PF07679) Pfam (PF13927) In PDB | Homo sapiens (human) | FGFR2, KERATINOCYTE GROWTH FACTOR RECEPTOR |
| 3 | water | water | 18.0 | 77 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 155 (UniProt: P09038)
E, F, G, H: 147 - 366 (UniProt: P21802)
| PDB | External Database | Details |
|---|---|---|
| Ser 78 | Cys 78 | engineered mutation |
| Ser 96 | Cys 96 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Arg 253 | Pro 253 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 167803.0 | |
| All* | Total formula weight | 167803.0 |
