1E0O
CRYSTAL STRUCTURE OF A TERNARY FGF1-FGFR2-HEPARIN COMPLEX
Summary for 1E0O
Entry DOI | 10.2210/pdb1e0o/pdb |
Related | 1AXM 1CVS 1DJS 2AXM |
Descriptor | FIBROBLAST GROWTH FACTOR 1, FIBROBLAST GROWTH FACTOR RECEPTOR 2, 2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, ... (6 entities in total) |
Functional Keywords | growth factor, receptor tyrosine kinase, heparin, ternary complex, signal transduction |
Biological source | HOMO SAPIENS (HUMAN) More |
Total number of polymer chains | 4 |
Total formula weight | 84448.54 |
Authors | Pellegrini, L.,Burke, D.F.,von Delft, F.,Mulloy, B.,Blundell, T.L. (deposition date: 2000-04-03, release date: 2000-10-23, Last modification date: 2020-07-29) |
Primary citation | Pellegrini, L.,Burke, D.F.,von Delft, F.,Mulloy, B.,Blundell, T.L. Crystal Structure of Fibroblast Growth Factor Receptor Ectodomain Bound to Ligand and Heparin Nature, 407:1029-, 2000 Cited by PubMed: 11069186DOI: 10.1038/35039551 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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