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1E0O

CRYSTAL STRUCTURE OF A TERNARY FGF1-FGFR2-HEPARIN COMPLEX

Functional Information from GO Data
ChainGOidnamespacecontents
A0001525biological_processangiogenesis
A0001759biological_processorgan induction
A0001934biological_processpositive regulation of protein phosphorylation
A0005104molecular_functionfibroblast growth factor receptor binding
A0005178molecular_functionintegrin binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005938cellular_componentcell cortex
A0007165biological_processsignal transduction
A0008083molecular_functiongrowth factor activity
A0008201molecular_functionheparin binding
A0008284biological_processpositive regulation of cell population proliferation
A0008543biological_processfibroblast growth factor receptor signaling pathway
A0009653biological_processanatomical structure morphogenesis
A0009887biological_processanimal organ morphogenesis
A0010595biological_processpositive regulation of endothelial cell migration
A0010628biological_processpositive regulation of gene expression
A0030154biological_processcell differentiation
A0030324biological_processlung development
A0030335biological_processpositive regulation of cell migration
A0030544molecular_functionHsp70 protein binding
A0031012cellular_componentextracellular matrix
A0032148biological_processactivation of protein kinase B activity
A0034605biological_processcellular response to heat
A0042060biological_processwound healing
A0043406biological_processpositive regulation of MAP kinase activity
A0044548molecular_functionS100 protein binding
A0045542biological_processpositive regulation of cholesterol biosynthetic process
A0045766biological_processpositive regulation of angiogenesis
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0050673biological_processepithelial cell proliferation
A0050679biological_processpositive regulation of epithelial cell proliferation
A0051781biological_processpositive regulation of cell division
A0060681biological_processbranch elongation involved in ureteric bud branching
A0070374biological_processpositive regulation of ERK1 and ERK2 cascade
A0072163biological_processmesonephric epithelium development
A1901509biological_processregulation of endothelial tube morphogenesis
A1902533biological_processpositive regulation of intracellular signal transduction
A1903672biological_processpositive regulation of sprouting angiogenesis
A2000347biological_processpositive regulation of hepatocyte proliferation
A2000544biological_processregulation of endothelial cell chemotaxis to fibroblast growth factor
C0001525biological_processangiogenesis
C0001759biological_processorgan induction
C0001934biological_processpositive regulation of protein phosphorylation
C0005104molecular_functionfibroblast growth factor receptor binding
C0005178molecular_functionintegrin binding
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0005938cellular_componentcell cortex
C0007165biological_processsignal transduction
C0008083molecular_functiongrowth factor activity
C0008201molecular_functionheparin binding
C0008284biological_processpositive regulation of cell population proliferation
C0008543biological_processfibroblast growth factor receptor signaling pathway
C0009653biological_processanatomical structure morphogenesis
C0009887biological_processanimal organ morphogenesis
C0010595biological_processpositive regulation of endothelial cell migration
C0010628biological_processpositive regulation of gene expression
C0030154biological_processcell differentiation
C0030324biological_processlung development
C0030335biological_processpositive regulation of cell migration
C0030544molecular_functionHsp70 protein binding
C0031012cellular_componentextracellular matrix
C0032148biological_processactivation of protein kinase B activity
C0034605biological_processcellular response to heat
C0042060biological_processwound healing
C0043406biological_processpositive regulation of MAP kinase activity
C0044548molecular_functionS100 protein binding
C0045542biological_processpositive regulation of cholesterol biosynthetic process
C0045766biological_processpositive regulation of angiogenesis
C0045944biological_processpositive regulation of transcription by RNA polymerase II
C0050673biological_processepithelial cell proliferation
C0050679biological_processpositive regulation of epithelial cell proliferation
C0051781biological_processpositive regulation of cell division
C0060681biological_processbranch elongation involved in ureteric bud branching
C0070374biological_processpositive regulation of ERK1 and ERK2 cascade
C0072163biological_processmesonephric epithelium development
C1901509biological_processregulation of endothelial tube morphogenesis
C1902533biological_processpositive regulation of intracellular signal transduction
C1903672biological_processpositive regulation of sprouting angiogenesis
C2000347biological_processpositive regulation of hepatocyte proliferation
C2000544biological_processregulation of endothelial cell chemotaxis to fibroblast growth factor
Functional Information from PROSITE/UniProt
site_idPS00247
Number of Residues24
DetailsHBGF_FGF HBGF/FGF family signature. GlLyGsqtpne.EClFlErleenhY
ChainResidueDetails
AGLY71-TYR94

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues12
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
BASN228
DASN297
DASN318
DASN331
BASN241
BASN265
BASN297
BASN318
BASN331
DASN228
DASN241
DASN265

218853

PDB entries from 2024-04-24

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