1E0O

CRYSTAL STRUCTURE OF A TERNARY FGF1-FGFR2-HEPARIN COMPLEX

Summary for 1E0O

• Entry DOI: 10.2210/pdb1e0o/pdb
• Related: 1AXM 1CVS 1DJS 2AXM
• Descriptor: FIBROBLAST GROWTH FACTOR 1, FIBROBLAST GROWTH FACTOR RECEPTOR 2, 2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, ... (6 entities in total)
• Functional Keywords: growth factor, receptor tyrosine kinase, heparin, ternary complex, signal transduction
• Biological source: HOMO SAPIENS (HUMAN); More
• Total number of polymer chains: 4
• Total formula weight: 84448.54

Authors

Pellegrini, L.,Burke, D.F.,von Delft, F.,Mulloy, B.,Blundell, T.L. (deposition date: 2000-04-03, release date: 2000-10-23, Last modification date: 2020-07-29)

• Primary citation: Pellegrini, L.,Burke, D.F.,von Delft, F.,Mulloy, B.,Blundell, T.L.; Crystal Structure of Fibroblast Growth Factor Receptor Ectodomain Bound to Ligand and Heparin; Nature, 407:1029-, 2000; PubMed: 11069186; DOI: 10.1038/35039551

Experimental method

X-RAY DIFFRACTION (2.8 Å)