1E0O

CRYSTAL STRUCTURE OF A TERNARY FGF1-FGFR2-HEPARIN COMPLEX

Summary for 1E0O

Related1AXM 2AXM 1DJS 1CVS
DescriptorFIBROBLAST GROWTH FACTOR 1, FIBROBLAST GROWTH FACTOR RECEPTOR 2, 2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, ... (6 entities in total)
Functional Keywordsgrowth factor, receptor tyrosine kinase, heparin, ternary complex, signal transduction
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationSecreted P05230
Cell membrane; Single-pass type I membrane protein. Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 3: Cell membrane; Single-pass type I membrane protein. Isoform 14: Secreted. Isoform 19: Secreted P21802
Total number of polymer chains4
Total molecular weight84448.54
Authors
Pellegrini, L.,Burke, D.F.,von Delft, F.,Mulloy, B.,Blundell, T.L. (deposition date: 2000-04-03, release date: 2000-10-23, Last modification date: 2020-07-29)
Primary citation
Pellegrini, L.,Burke, D.F.,von Delft, F.,Mulloy, B.,Blundell, T.L.
Crystal Structure of Fibroblast Growth Factor Receptor Ectodomain Bound to Ligand and Heparin
Nature, 407:1029-, 2000
PubMed: 11069186 (PDB entries with the same primary citation)
DOI: 10.1038/35039551
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.8 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliers30 3.6% 4.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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171588
PDB entries from 2020-11-25