1QPE

STRUCTURAL ANALYSIS OF THE LYMPHOCYTE-SPECIFIC KINASE LCK IN COMPLEX WITH NON-SELECTIVE AND SRC FAMILY SELECTIVE KINASE INHIBITORS

Summary for 1QPE

Related1QPC 1QPD 1QPJ
DescriptorLCK KINASE, SULFATE ION, 1-TERT-BUTYL-3-(4-CHLORO-PHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-YLAMINE, ... (4 entities in total)
Functional Keywordsalpha beta fold, transferase
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm P06239
Total number of polymer chains1
Total molecular weight32944.79
Authors
Zhu, X.,Morgenstern, K.A. (deposition date: 1999-05-24, release date: 2000-05-31, Last modification date: 2011-07-13)
Primary citation
Zhu, X.,Kim, J.L.,Newcomb, J.R.,Rose, P.E.,Stover, D.R.,Toledo, L.M.,Zhao, H.,Morgenstern, K.A.
Structural analysis of the lymphocyte-specific kinase Lck in complex with non-selective and Src family selective kinase inhibitors.
Structure Fold.Des., 7:651-661, 1999
PubMed: 10404594 (PDB entries with the same primary citation)
DOI: 10.1016/S0969-2126(99)80086-0
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliers60 3.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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PDB entries from 2020-11-25