7SGL
 
 | | DNA-PK complex of DNA end processing | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, DNA-dependent protein kinase catalytic subunit, Hairpin_1, ... | | 著者 | Liu, L, Li, J, Chen, X, Yang, W, Gellert, M. | | 登録日 | 2021-10-06 | | 公開日 | 2022-01-12 | | 最終更新日 | 2022-01-19 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Autophosphorylation transforms DNA-PK from protecting to processing DNA ends.
Mol.Cell, 82, 2022
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7SU3
 | | CryoEM structure of DNA-PK complex VII | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, DNA (5'-D(*AP*AP*GP*CP*AP*GP*TP*AP*GP*AP*G)-3'), DNA (5'-D(*GP*CP*AP*TP*GP*CP*TP*CP*TP*AP*CP*TP*GP*CP*TP*TP*CP*GP*AP*TP*AP*TP*CP*G)-3'), ... | | 著者 | Chen, X, Liu, L, Gellert, M, Yang, W. | | 登録日 | 2021-11-16 | | 公開日 | 2022-01-12 | | 最終更新日 | 2022-01-19 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Autophosphorylation transforms DNA-PK from protecting to processing DNA ends.
Mol.Cell, 82, 2022
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7SUD
 | | CryoEM structure of DNA-PK complex VIII | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, DNA-dependent protein kinase catalytic subunit, MAGNESIUM ION, ... | | 著者 | Chen, X, Liu, L, Gellert, M, Yang, W. | | 登録日 | 2021-11-16 | | 公開日 | 2022-01-12 | | 最終更新日 | 2022-01-19 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Autophosphorylation transforms DNA-PK from protecting to processing DNA ends.
Mol.Cell, 82, 2022
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7Z6O
 | | X-Ray studies of Ku70/80 reveal the binding site for IP6 | | 分子名称: | DNA (5'-D(*GP*TP*TP*TP*TP*TP*AP*GP*TP*TP*TP*AP*T)-3'), DNA (5'-D(P*AP*AP*AP*TP*AP*AP*AP*CP*TP*AP*AP*AP*AP*AP*C)-3'), INOSITOL HEXAKISPHOSPHATE, ... | | 著者 | Varela, P.F, Charbonnier, J.B. | | 登録日 | 2022-03-14 | | 公開日 | 2023-08-30 | | 最終更新日 | 2023-12-06 | | 実験手法 | X-RAY DIFFRACTION (3.7 Å) | | 主引用文献 | Structural and functional basis of inositol hexaphosphate stimulation of NHEJ through stabilization of Ku-XLF interaction.
Nucleic Acids Res., 51, 2023
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7Z88
 | | DNA-PK in the intermediate state | | 分子名称: | (~{S})-[2-chloranyl-4-fluoranyl-5-(7-morpholin-4-ylquinazolin-4-yl)phenyl]-(6-methoxypyridazin-3-yl)methanol, DNA (26-MER), DNA-dependent protein kinase catalytic subunit, ... | | 著者 | Liang, S, Blundell, T.L. | | 登録日 | 2022-03-16 | | 公開日 | 2023-01-18 | | 最終更新日 | 2023-03-01 | | 実験手法 | ELECTRON MICROSCOPY (3.33 Å) | | 主引用文献 | Human DNA-dependent protein kinase activation mechanism.
Nat.Struct.Mol.Biol., 30, 2023
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7Z87
 | | DNA-PK in the active state | | 分子名称: | (~{S})-[2-chloranyl-4-fluoranyl-5-(7-morpholin-4-ylquinazolin-4-yl)phenyl]-(6-methoxypyridazin-3-yl)methanol, DNA (26-MER), DNA-dependent protein kinase catalytic subunit, ... | | 著者 | Liang, S, Blundell, T.L. | | 登録日 | 2022-03-16 | | 公開日 | 2023-01-18 | | 最終更新日 | 2023-03-01 | | 実験手法 | ELECTRON MICROSCOPY (2.91 Å) | | 主引用文献 | Human DNA-dependent protein kinase activation mechanism.
Nat.Struct.Mol.Biol., 30, 2023
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7ZT6
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7ZVT
 | | CryoEM structure of Ku heterodimer bound to DNA | | 分子名称: | DNA (5'-D(P*CP*GP*AP*TP*AP*TP*CP*TP*AP*GP*AP*GP*GP*GP*AP*T)-3'), DNA (5'-D(P*TP*CP*CP*CP*TP*CP*TP*AP*GP*AP*TP*AP*TP*C)-3'), INOSITOL HEXAKISPHOSPHATE, ... | | 著者 | Hardwick, S.W, Kefala-Stavridi, A, Chirgadze, D.Y, Blundell, T.L, Chaplin, A.K. | | 登録日 | 2022-05-17 | | 公開日 | 2023-05-24 | | 最終更新日 | 2023-12-06 | | 実験手法 | ELECTRON MICROSCOPY (2.74 Å) | | 主引用文献 | Structural and functional basis of inositol hexaphosphate stimulation of NHEJ through stabilization of Ku-XLF interaction.
Nucleic Acids Res., 51, 2023
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7ZWA
 | | CryoEM structure of Ku heterodimer bound to DNA and PAXX | | 分子名称: | DNA (5'-D(P*CP*GP*AP*TP*AP*TP*CP*TP*AP*GP*AP*GP*GP*GP*AP*TP*C)-3'), DNA (5'-D(P*GP*AP*TP*CP*CP*CP*TP*CP*TP*AP*GP*AP*TP*AP*T)-3'), PHOSPHATE ION, ... | | 著者 | Hardwick, S.W, Kefala-Stavridi, A, Chirgadze, D.Y, Blundell, T.L, Chaplin, A.K. | | 登録日 | 2022-05-19 | | 公開日 | 2023-05-31 | | 最終更新日 | 2023-06-14 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | PAXX binding to the NHEJ machinery explains functional redundancy with XLF.
Sci Adv, 9, 2023
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7ZYG
 | | CryoEM structure of Ku heterodimer bound to DNA, PAXX and XLF | | 分子名称: | DNA, Non-homologous end-joining factor 1, PHOSPHATE ION, ... | | 著者 | Hardwick, S.W, Kefala-Stavridi, A, Chirgadze, D.Y, Blundell, T.L, Chaplin, A.K. | | 登録日 | 2022-05-24 | | 公開日 | 2023-06-07 | | 最終更新日 | 2023-06-14 | | 実験手法 | ELECTRON MICROSCOPY (2.68 Å) | | 主引用文献 | PAXX binding to the NHEJ machinery explains functional redundancy with XLF.
Sci Adv, 9, 2023
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8AG4
 | | Vaccinia C16 protein bound to Ku70/Ku80 | | 分子名称: | Protein C10, X-ray repair cross-complementing protein 5, X-ray repair cross-complementing protein 6 | | 著者 | Rivera-Calzada, A, Arribas-Bosacoma, R, Pearl, L.H, Llorca, O. | | 登録日 | 2022-07-19 | | 公開日 | 2022-11-09 | | 最終更新日 | 2022-11-30 | | 実験手法 | ELECTRON MICROSCOPY (2.46 Å) | | 主引用文献 | Structural basis for the inactivation of cytosolic DNA sensing by the vaccinia virus.
Nat Commun, 13, 2022
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8AG5
 | | Vaccinia C16 protein bound to Ku70/Ku80 | | 分子名称: | Ku70-Xrcc6, Protein C10, X-ray repair cross-complementing protein 5 | | 著者 | Rivera-Calzada, A, Arribas-Bosacoma, R, Pearl, L.H, Llorca, O. | | 登録日 | 2022-07-19 | | 公開日 | 2022-11-09 | | 最終更新日 | 2022-11-30 | | 実験手法 | ELECTRON MICROSCOPY (3.47 Å) | | 主引用文献 | Structural basis for the inactivation of cytosolic DNA sensing by the vaccinia virus.
Nat Commun, 13, 2022
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8ASC
 | | Ku70/80 binds to the Ku-binding motif of PAXX | | 分子名称: | DNA (5'-D(P*CP*GP*GP*AP*TP*CP*GP*AP*GP*GP*GP*CP*CP*CP*GP*AP*TP*AP*T)-3'), DNA (5'-D(P*GP*GP*GP*CP*CP*CP*TP*CP*GP*AP*TP*CP*CP*G)-3'), Protein PAXX, ... | | 著者 | Seif El Dahan, M, Ropars, V, Charbonnier, J.B. | | 登録日 | 2022-08-19 | | 公開日 | 2023-06-21 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | | 主引用文献 | PAXX binding to the NHEJ machinery explains functional redundancy with XLF.
Sci Adv, 9, 2023
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8BH3
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8EZA
 | | NHEJ Long-range complex with PAXX | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, DNA (30-MER), DNA (31-MER), ... | | 著者 | Chen, S, He, Y. | | 登録日 | 2022-10-31 | | 公開日 | 2023-06-14 | | 実験手法 | ELECTRON MICROSCOPY (4.39 Å) | | 主引用文献 | Cryo-EM visualization of DNA-PKcs structural intermediates in NHEJ.
Sci Adv, 9, 2023
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8EZB
 | | NHEJ Long-range complex with ATP | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, DNA (30-MER), DNA (31-MER), ... | | 著者 | Chen, S, He, Y. | | 登録日 | 2022-10-31 | | 公開日 | 2023-06-14 | | 実験手法 | ELECTRON MICROSCOPY (8.9 Å) | | 主引用文献 | Cryo-EM visualization of DNA-PKcs structural intermediates in NHEJ.
Sci Adv, 9, 2023
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8BHV
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8BHY
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8BOT
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