PDB: 155 件ウェブページステータス検索Chemie searchBIRD

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1RV1	CRYSTAL STRUCTURE OF HUMAN MDM2 WITH AN IMIDAZOLINE INHIBITOR 分子名称: CIS-[4,5-BIS-(4-BROMOPHENYL)-2-(2-ETHOXY-4-METHOXYPHENYL)-4,5-DIHYDROIMIDAZOL-1-YL]-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]METHANONE, Ubiquitin-protein ligase E3 Mdm2 著者 Lukacs, C, Kammlott, U, Graves, B. 登録日 2003-12-12 公開日 2004-01-20 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science, 303, 2004
1T4E	Structure of Human MDM2 in complex with a Benzodiazepine Inhibitor 分子名称: (4-CHLOROPHENYL)[3-(4-CHLOROPHENYL)-7-IODO-2,5-DIOXO-1,2,3,5-TETRAHYDRO-4H-1,4-BENZODIAZEPIN-4-YL]ACETIC ACID, Ubiquitin-protein ligase E3 Mdm2 著者 Grasberger, B.L, Schubert, C, Koblish, H.K, Carver, T.E, Franks, C.F, Zhao, S.Y, Lu, T, LaFrance, L.V, Parks, D.J. 登録日 2004-04-29 公開日 2005-02-08 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Discovery and cocrystal structure of benzodiazepinedione HDM2 antagonists that activate p53 in cells J.Med.Chem., 48, 2005
1T4F	Structure of human MDM2 in complex with an optimized p53 peptide 分子名称: SULFATE ION, Ubiquitin-protein ligase E3 Mdm2, optimized p53 peptide 著者 Grasberger, B.L, Schubert, C, Koblish, H.K, Carver, T.E, Franks, C.F, Zhao, S.Y, Lu, T, LaFrance, L.V, Parks, D.J. 登録日 2004-04-29 公開日 2005-02-08 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Discovery and cocrystal structure of benzodiazepinedione HDM2 antagonists that activate p53 in cells J.Med.Chem., 48, 2005
1TTV	NMR Structure of a Complex Between MDM2 and a Small Molecule Inhibitor 分子名称: 1-{[4,5-BIS(4-CHLOROPHENYL)-2-(2-ISOPROPOXY-4-METHOXYPHENYL)-4,5-DIHYDRO-1H-IMIDAZOL-1-YL]CARBONYL}PIPERAZINE, Ubiquitin-protein ligase E3 Mdm2 著者 Fry, D.C, Emerson, S.D, Palme, S, Vu, B.T, Liu, C.M, Podlaski, F. 登録日 2004-06-23 公開日 2005-01-04 最終更新日 2021-10-27 実験手法 SOLUTION NMR 主引用文献 NMR structure of a complex between MDM2 and a small molecule inhibitor. J.Biomol.Nmr, 30, 2004
1UHR	Solution structure of the SWIB domain of mouse BRG1-associated factor 60a 分子名称: SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily D member 1 著者 Yamada, K, Saito, K, Nameki, N, Inoue, M, Koshiba, S, Shirouzu, M, Terada, T, Yabuki, T, Aoki, M, Matsuda, T, Seki, E, Hirota, H, Yoshida, M, Tanaka, A, Osanai, T, Arakawa, T, Carninci, P, Kawai, J, Hayashizaki, Y, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2003-07-09 公開日 2004-08-24 最終更新日 2023-12-27 実験手法 SOLUTION NMR 主引用文献 Solution structure of the SWIB domain of mouse BRG1-associated factor 60a To be Published
1V31	Solution structure of the SWIB/MDM2 domain of the hypothetical protein At5g14170 from Arabidopsis thaliana 分子名称: hypothetical protein RAFL11-05-P19 著者 Yoneyama, M, Tochio, N, Koshiba, S, Inoue, M, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2003-10-21 公開日 2004-04-21 最終更新日 2023-12-27 実験手法 SOLUTION NMR 主引用文献 Solution structure of the SWIB/MDM2 domain of the hypothetical protein At5g14170 from Arabidopsis thaliana To be Published
1V32	Solution structure of the SWIB/MDM2 domain of the hypothetical protein At5g08430 from Arabidopsis thaliana 分子名称: hypothetical protein RAFL09-47-K03 著者 Yoneyama, M, Tochio, N, Koshiba, S, Inoue, M, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2003-10-24 公開日 2004-04-24 最終更新日 2023-12-27 実験手法 SOLUTION NMR 主引用文献 Solution structure of the SWIB/MDM2 domain of the hypothetical protein At5g08430 from Arabidopsis thaliana To be Published
1YCQ	XENOPUS LAEVIS MDM2 BOUND TO THE TRANSACTIVATION DOMAIN OF HUMAN P53 分子名称: MDM2, P53 著者 Kussie, P.H, Pavletich, N.P. 登録日 1996-09-30 公開日 1997-11-19 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain. Science, 274, 1996
1YCR	MDM2 BOUND TO THE TRANSACTIVATION DOMAIN OF P53 分子名称: MDM2, P53 著者 Kussie, P.H, Pavletich, N.P. 登録日 1996-09-30 公開日 1997-11-19 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain. Science, 274, 1996
1Z1M	NMR structure of unliganded MDM2 分子名称: Ubiquitin-protein ligase E3 Mdm2 著者 Uhrinova, S, Uhrin, D, Powers, H, Watt, K, Zheleva, D, Fischer, P, McInnes, C, Barlow, P.N. 登録日 2005-03-04 公開日 2005-06-28 最終更新日 2022-03-02 実験手法 SOLUTION NMR 主引用文献 Structure of Free MDM2 N-terminal Domain Reveals Conformational Adjustments that Accompany p53-binding J.Mol.Biol., 350, 2005
2AXI	HDM2 in complex with a beta-hairpin 分子名称: 3[N-MORPHOLINO]PROPANE SULFONIC ACID, SULFATE ION, Ubiquitin-protein ligase E3 Mdm2, ... 著者 Mittl, P.R.E, Fasan, R, Robinson, J, Gruetter, M.G. 登録日 2005-09-05 公開日 2006-03-21 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Structure-Activity Studies in a Family of beta-Hairpin Protein Epitope Mimetic Inhibitors of the p53-HDM2 Protein-Protein Interaction. Chembiochem, 7, 2006
2GV2	MDM2 in complex with an 8-mer p53 peptide analogue 分子名称: 8-MER P53 PEPTIDE ANALOGUE, E3 ubiquitin-protein ligase Mdm2 著者 Schubert, C, Sakurai, K. 登録日 2006-05-02 公開日 2006-09-05 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Crystallographic Analysis of an 8-mer p53 Peptide Analogue Complexed with MDM2. J.Am.Chem.Soc., 128, 2006
2LZG	NMR Structure of Mdm2 (6-125) with Pip-1 分子名称: E3 ubiquitin-protein ligase Mdm2, [(3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-(cyclopropylmethyl)-2-oxopiperidin-3-yl]acetic acid 著者 Michelsen, K.B, Jordan, J.B, Lewis, J, Long, A.M, Yang, E, Rew, Y, Zhou, J, Yakowec, P, Schnier, P.D, Huang, X, Poppe, L. 登録日 2012-10-02 公開日 2012-11-07 最終更新日 2024-05-01 実験手法 SOLUTION NMR 主引用文献 Ordering of the N-Terminus of Human MDM2 by Small Molecule Inhibitors. J.Am.Chem.Soc., 134, 2012
2M86	Solution structure of Hdm2 with engineered cyclotide 分子名称: E3 ubiquitin-protein ligase Mdm2, MCo-PMI 著者 Majumder, S, Ji, Y, Millard, M, Borra, R, Bi, T, Elnagar, A.Y, Neamati, N, Camarero, J.A. 登録日 2013-05-07 公開日 2013-07-31 最終更新日 2023-06-14 実験手法 SOLUTION NMR 主引用文献 In Vivo Activation of the p53 Tumor Suppressor Pathway by an Engineered Cyclotide. J.Am.Chem.Soc., 135, 2013
2MPS	Structure of complex of MDM2(3-109) and P73 TAD(10-25) 分子名称: E3 ubiquitin-protein ligase Mdm2, Tumor protein p73 著者 Shin, J.S, Ha, J.H, Chi, S.W. 登録日 2014-06-02 公開日 2015-06-03 最終更新日 2023-06-14 実験手法 SOLUTION NMR 主引用文献 Structural convergence of unstructured p53 family transactivation domains in MDM2 recognition Cell Cycle, 14, 2015
2RUH	Chemical Shift Assignments for MIP and MDM2 in bound state 分子名称: E3 ubiquitin-protein ligase Mdm2 著者 Nagata, T, Shirakawa, K, Kobayashi, N, Shiheido, H, Horisawa, K, Katahira, M, Doi, N, Yanagawa, H. 登録日 2014-06-03 公開日 2014-10-15 最終更新日 2023-06-14 実験手法 SOLUTION NMR 主引用文献 Structural Basis for Inhibition of the MDM2:p53 Interaction by an Optimized MDM2-Binding Peptide Selected with mRNA Display Plos One, 9, 2014
2Z5S	Molecular basis for the inhibition of p53 by Mdmx 分子名称: Cellular tumor antigen p53, Mdm4 protein 著者 Popowicz, G.M, Czarna, A, Rothweiler, U, Szwagierczak, A, Holak, T.A. 登録日 2007-07-17 公開日 2007-11-06 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Molecular basis for the inhibition of p53 by Mdmx. Cell Cycle, 6, 2007
2Z5T	Molecular basis for the inhibition of p53 by Mdmx 分子名称: Cellular tumor antigen p53, Mdm4 protein 著者 Popowicz, G.M, Czarna, A, Rothweiler, U, Szwagierczak, A, Holak, T.A. 登録日 2007-07-17 公開日 2007-11-06 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Molecular basis for the inhibition of p53 by Mdmx. Cell Cycle, 6, 2007
3DAC	Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain 分子名称: Cellular tumor antigen p53, Mdm4 protein 著者 Popowicz, G.M, Czarna, A, Holak, T.A. 登録日 2008-05-29 公開日 2008-09-02 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain. Cell Cycle, 7, 2008
3EQS	Crystal structure of human MDM2 in complex with a 12-mer peptide inhibitor 分子名称: 12-mer peptide inhibitor, E3 ubiquitin-protein ligase Mdm2, GUANIDINE 著者 Pazgier, M, Lu, W. 登録日 2008-10-01 公開日 2009-03-17 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Structural basis for high-affinity peptide inhibition of p53 interactions with MDM2 and MDMX. Proc.Natl.Acad.Sci.USA, 106, 2009
3G03	Structure of human MDM2 in complex with high affinity peptide 分子名称: E3 ubiquitin-protein ligase Mdm2, High affinity synthetic peptide 著者 Czarna, A.L, Popowicz, G.M, Holak, T.A. 登録日 2009-01-27 公開日 2009-04-14 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 High affinity interaction of the p53 peptide-analogue with human Mdm2 and Mdmx. Cell Cycle, 8, 2009
3IUX	Crystal structure of human MDM2 in complex with a potent miniature protein inhibitor (18-residues) 分子名称: ACETATE ION, CHLORIDE ION, E3 ubiquitin-protein ligase Mdm2, ... 著者 Pazgier, M, Lu, W. 登録日 2009-08-31 公開日 2009-10-27 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Apamin as a template for structure-based rational design of potent peptide activators of p53. Angew.Chem.Int.Ed.Engl., 48, 2009
3IWY	Crystal structure of human MDM2 complexed with D-peptide (12 residues) 分子名称: D-peptide inhibitor, E3 ubiquitin-protein ligase Mdm2 著者 Pazgier, M, Lu, W. 登録日 2009-09-03 公開日 2010-04-21 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.93 Å) 主引用文献 D-peptide inhibitors of the p53-MDM2 interaction for targeted molecular therapy of malignant neoplasms. Proc.Natl.Acad.Sci.USA, 398, 2010
3JZK	crystal structure of MDM2 with chromenotriazolopyrimidine 1 分子名称: (6R,7S)-6,7-bis(4-bromophenyl)-7,11-dihydro-6H-chromeno[4,3-d][1,2,4]triazolo[1,5-a]pyrimidine, E3 ubiquitin-protein ligase Mdm2 著者 Huang, X. 登録日 2009-09-23 公開日 2009-11-17 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Discovery and optimization of chromenotriazolopyrimidines as potent inhibitors of the mouse double minute 2-tumor protein 53 protein-protein interaction. J.Med.Chem., 52, 2009
3JZR	Human MDM2 liganded with a 12mer peptide inhibitor (pDI6W) 分子名称: E3 ubiquitin-protein ligase Mdm2, pDI6W peptide (12mer) 著者 Schonbrunn, E, Phan, J. 登録日 2009-09-24 公開日 2009-11-10 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structure-based design of high affinity peptides inhibiting the interaction of p53 with MDM2 and MDMX. J.Biol.Chem., 285, 2010

 

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