PDB: 281 件ウェブページステータス検索Chemie searchBIRD

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2ZXG	Aminopeptidase N complexed with the aminophosphinic inhibitor of PL250, a transition state analogue 分子名称: Aminopeptidase N, GLYCEROL, N-{(2S)-3-[(1R)-1-aminoethyl](hydroxy)phosphoryl-2-benzylpropanoyl}-L-phenylalanine, ... 著者 Nakajima, Y, Ito, K, Yoshimoto, T. 登録日 2008-12-24 公開日 2009-08-25 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Structure of aminopeptidase N from Escherichia coli complexed with the transition-state analogue aminophosphinic inhibitor PL250 Acta Crystallogr.,Sect.D, 65, 2009
3FH7	Leukotriene A4 Hydrolase complexed with inhibitor 4-[(2S)-2-{[4-(4-chlorophenoxy)phenoxy]methyl}pyrrolidin-1-yl]butanoate. 分子名称: 4-[(2S)-2-{[4-(4-chlorophenoxy)phenoxy]methyl}pyrrolidin-1-yl]butanoate, ACETATE ION, GLYCEROL, ... 著者 Mamat, B, Davies, D.R. 登録日 2008-12-08 公開日 2010-01-05 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Discovery of 4-[(2S)-2-{[4-(4-chlorophenoxy)phenoxy]methyl}-1-pyrrolidinyl]butanoic acid (DG-051) as a novel leukotriene A4 hydrolase inhibitor of leukotriene B4 biosynthesis. J.Med.Chem., 53, 2010
3FH5	Leukotriene A4 Hydrolase complexed with inhibitor (2R)-2-[(4-benzylphenoxy)methyl]pyrrolidine. 分子名称: (2R)-2-[(4-benzylphenoxy)methyl]pyrrolidine, ACETATE ION, GLYCEROL, ... 著者 Mamat, B, Davies, D.R. 登録日 2008-12-08 公開日 2010-01-05 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.63 Å) 主引用文献 Discovery of 4-[(2S)-2-{[4-(4-chlorophenoxy)phenoxy]methyl}-1-pyrrolidinyl]butanoic acid (DG-051) as a novel leukotriene A4 hydrolase inhibitor of leukotriene B4 biosynthesis. J.Med.Chem., 53, 2010
3FH8	Leukotriene A4 Hydrolase complexed with inhibitor 1-[2-(4-benzylphenoxy)ethyl]pyrrolidine. 分子名称: 1-[2-(4-benzylphenoxy)ethyl]pyrrolidine, ACETATE ION, IMIDAZOLE, ... 著者 Mamat, B, Davies, D.R. 登録日 2008-12-09 公開日 2010-01-05 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.67 Å) 主引用文献 Discovery of 4-[(2S)-2-{[4-(4-chlorophenoxy)phenoxy]methyl}-1-pyrrolidinyl]butanoic acid (DG-051) as a novel leukotriene A4 hydrolase inhibitor of leukotriene B4 biosynthesis. J.Med.Chem., 53, 2010
3FHE	Leukotriene A4 Hydrolase complexed with inhibitor N-[3-(4-benzylphenoxy)propyl]-N-methyl-beta-alanine. 分子名称: ACETATE ION, IMIDAZOLE, Leukotriene A-4 hydrolase, ... 著者 Mamat, B, Davies, D.R. 登録日 2008-12-09 公開日 2010-01-05 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.16 Å) 主引用文献 Discovery of 4-[(2S)-2-{[4-(4-chlorophenoxy)phenoxy]methyl}-1-pyrrolidinyl]butanoic acid (DG-051) as a novel leukotriene A4 hydrolase inhibitor of leukotriene B4 biosynthesis. J.Med.Chem., 53, 2010
3FTZ	Leukotriene A4 hydrolase in complex with fragment 2-(pyridin-3-ylmethoxy)aniline 分子名称: 2-(pyridin-3-ylmethoxy)aniline, ACETATE ION, IMIDAZOLE, ... 著者 Davies, D.R. 登録日 2009-01-13 公開日 2010-01-05 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Discovery of 4-[(2S)-2-{[4-(4-chlorophenoxy)phenoxy]methyl}-1-pyrrolidinyl]butanoic acid (DG-051) as a novel leukotriene A4 hydrolase inhibitor of leukotriene B4 biosynthesis. J.Med.Chem., 53, 2010
3FUL	Leukotriene A4 hydrolase in complex with pyridin-4-yl[4-(2-pyrrolidin-1-ylethoxy)phenyl]methanone 分子名称: IMIDAZOLE, Leukotriene A-4 hydrolase, YTTERBIUM (III) ION, ... 著者 Davies, D.R. 登録日 2009-01-14 公開日 2010-01-05 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.39 Å) 主引用文献 Discovery of 4-[(2S)-2-{[4-(4-chlorophenoxy)phenoxy]methyl}-1-pyrrolidinyl]butanoic acid (DG-051) as a novel leukotriene A4 hydrolase inhibitor of leukotriene B4 biosynthesis. J.Med.Chem., 53, 2010
3KED	Crystal structure of Aminopeptidase N in complex with 2,4-diaminobutyric acid 分子名称: 2,4-DIAMINOBUTYRIC ACID, Aminopeptidase N, GLYCEROL, ... 著者 Addlagatta, A, Gumpena, R. 登録日 2009-10-25 公開日 2010-11-03 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Discovery of alpha, beta- and alpha, gamma-Diamino Acid Scaffolds for the Inhibition of M1 Family Aminopeptidases Chemmedchem, 6, 2011
2XPZ	Structure of native yeast LTA4 hydrolase 分子名称: (R,R)-2,3-BUTANEDIOL, LEUKOTRIENE A-4 HYDROLASE, POLYETHYLENE GLYCOL (N=34), ... 著者 Helgstrand, C, Hasan, M, Usyal, H, Haeggstrom, J.Z, Thunnissen, M.M.G.M. 登録日 2010-08-31 公開日 2010-12-29 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 A Leukotriene A(4) Hydrolase-Related Aminopeptidase from Yeast Undergoes Induced Fit Upon Inhibitor Binding. J.Mol.Biol., 406, 2011
2XQ0	Structure of yeast LTA4 hydrolase in complex with Bestatin 分子名称: 2-(3-AMINO-2-HYDROXY-4-PHENYL-BUTYRYLAMINO)-4-METHYL-PENTANOIC ACID, CHLORIDE ION, LEUKOTRIENE A-4 HYDROLASE, ... 著者 Helgstrand, C, Hasan, M, Usyal, H, Haeggstrom, J.Z, Thunnissen, M.M.G.M. 登録日 2010-08-31 公開日 2010-12-29 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.955 Å) 主引用文献 A Leukotriene A(4) Hydrolase-Related Aminopeptidase from Yeast Undergoes Induced Fit Upon Inhibitor Binding. J.Mol.Biol., 406, 2011
2XPY	Structure of Native Leukotriene A4 Hydrolase from Saccharomyces cerevisiae 分子名称: GLUTATHIONE, GLYCEROL, LEUKOTRIENE A-4 HYDROLASE, ... 著者 Helgstrand, C, Hasan, M, Usyal, H, Haeggstrom, J.Z, Thunnissen, M.M.G.M. 登録日 2010-08-31 公開日 2010-12-29 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.73 Å) 主引用文献 A Leukotriene A(4) Hydrolase-Related Aminopeptidase from Yeast Undergoes Induced Fit Upon Inhibitor Binding. J.Mol.Biol., 406, 2011
3QNF	Crystal structure of the open state of human endoplasmic reticulum aminopeptidase 1 ERAP1 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Endoplasmic reticulum aminopeptidase 1, ZINC ION, ... 著者 Vollmar, M, Kochan, G, Krojer, T, Harvey, D, Chaikuad, A, Allerston, C, Muniz, J.R.C, Raynor, J, Ugochukwu, E, Berridge, G, Wordsworth, B.P, von Delft, F, Bountra, C, Arrowsmith, C.H, Edwards, A, Kavanagh, K, Oppermann, U, Structural Genomics Consortium (SGC) 登録日 2011-02-08 公開日 2011-02-23 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Crystal structures of the endoplasmic reticulum aminopeptidase-1 (ERAP1) reveal the molecular basis for N-terminal peptide trimming. Proc.Natl.Acad.Sci.USA, 108, 2011
3Q43	X-ray crystal structure of PfA-M1 bound to bestatin derivative 15 分子名称: GLYCEROL, M1 family aminopeptidase, MAGNESIUM ION, ... 著者 McGowan, S, Greenbaum, D.C. 登録日 2010-12-22 公開日 2011-03-16 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Synthesis of new (-)-bestatin-based inhibitor libraries reveals a novel binding mode in the s1 pocket of the essential malaria m1 metalloaminopeptidase. J.Med.Chem., 54, 2011
3Q44	X-ray crystal structure of PfA-M1 bound to Bestatin derivative 16 分子名称: GLYCEROL, M1 family aminopeptidase, MAGNESIUM ION, ... 著者 McGowan, S, Greenbaum, D.C. 登録日 2010-12-22 公開日 2011-03-16 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Synthesis of new (-)-bestatin-based inhibitor libraries reveals a novel binding mode in the s1 pocket of the essential malaria m1 metalloaminopeptidase. J.Med.Chem., 54, 2011
3MDJ	ER Aminopeptidase, ERAP1, Bound to the Zinc Aminopeptidase Inhibitor, Bestatin 分子名称: 2-(3-AMINO-2-HYDROXY-4-PHENYL-BUTYRYLAMINO)-4-METHYL-PENTANOIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Nguyen, T.T, Stern, L.J. 登録日 2010-03-30 公開日 2011-03-30 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.95 Å) 主引用文献 Structural basis for antigenic peptide precursor processing by the endoplasmic reticulum aminopeptidase ERAP1. Nat.Struct.Mol.Biol., 18, 2011
2YD0	Crystal structure of the soluble domain of human endoplasmic reticulum aminopeptidase 1 ERAP1 分子名称: 1,2-ETHANEDIOL, 2-(3-AMINO-2-HYDROXY-4-PHENYL-BUTYRYLAMINO)-4-METHYL-PENTANOIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Vollmar, M, Kochan, G, Krojer, T, Ugochukwu, E, Muniz, J.R.C, Raynor, J, Chaikuad, A, Allerston, C, von Delft, F, Bountra, C, Arrowsmith, C.H, Weigelt, J, Edwards, A, Knapp, S. 登録日 2011-03-17 公開日 2011-04-13 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Crystal Structures of the Endoplasmic Reticulum Aminopeptidase-1 (Erap1) Reveal the Molecular Basis for N-Terminal Peptide Trimming. Proc.Natl.Acad.Sci.USA, 108, 2011
3Q7J	Engineered Thermoplasma Acidophilum F3 factor mimics human aminopeptidase N (APN) as a target for anticancer drug development 分子名称: L-phenylalanyl-N6-[(benzyloxy)carbonyl]-N1-hydroxy-L-lysinamide, Tricorn protease-interacting factor F3, ZINC ION 著者 Su, J, Wang, Q, Feng, J, Zhang, C, Zhu, D, We, T, Xu, W, Gu, L. 登録日 2011-01-05 公開日 2011-07-27 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.91 Å) 主引用文献 Engineered Thermoplasma acidophilum factor F3 mimics human aminopeptidase N (APN) as a target for anticancer drug development Bioorg.Med.Chem., 19, 2011
3T8V	A bestatin-based chemical biology strategy reveals distinct roles for malaria M1- and M17-family aminopeptidases 分子名称: M1 family aminopeptidase, MAGNESIUM ION, N-[(2-{2-[(N-{(2S,3R)-3-amino-4-[4-(benzyloxy)phenyl]-2-hydroxybutanoyl}-L-alanyl)amino]ethoxy}ethoxy)acetyl]-4-benzoyl-L-phenylalanyl-N~6~-hex-5-ynoyllysinamide, ... 著者 McGowan, S, Klemba, M, Greebaum, D.C. 登録日 2011-08-01 公開日 2011-09-28 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Bestatin-based chemical biology strategy reveals distinct roles for malaria M1- and M17-family aminopeptidases Proc.Natl.Acad.Sci.USA, 108, 2011
3PUU	Crystal Structure of Glu121Gln mutant of E. coli Aminopeptidase N 分子名称: Aminopeptidase N, GLYCEROL, SULFATE ION, ... 著者 Addlagatta, A. 登録日 2010-12-06 公開日 2011-11-16 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Discovery of alpha, beta- and alpha, gamma-Diamino Acid Scaffolds for the Inhibition of M1 Family Aminopeptidases Chemmedchem, 6, 2011
3QJX	Crystal Structure of E. coli Aminopeptidase N in complex with L-Serine 分子名称: Aminopeptidase N, GLYCEROL, MALONATE ION, ... 著者 Addlagatta, A, Gumpena, R, Kishor, C, Ganji, R.J. 登録日 2011-01-31 公開日 2011-11-16 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Discovery of alpha, beta- and alpha, gamma-Diamino Acid Scaffolds for the Inhibition of M1 Family Aminopeptidases Chemmedchem, 6, 2011
3SE6	Crystal structure of the human Endoplasmic Reticulum Aminopeptidase 2 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Birtley, J.R, Saridakis, E, Stratikos, E, Mavridis, I.M. 登録日 2011-06-10 公開日 2011-12-21 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (3.08 Å) 主引用文献 The crystal structure of human endoplasmic reticulum aminopeptidase 2 reveals the atomic basis for distinct roles in antigen processing. Biochemistry, 51, 2012
4F5C	Crystal structure of the spike receptor binding domain of a porcine respiratory coronavirus in complex with the pig aminopeptidase N ectodomain 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Aminopeptidase N, ... 著者 Santiago, C, Reguera, J, Gaurav, M, Ordono, D, Enjuanes, L, Casasnovas, J.M. 登録日 2012-05-13 公開日 2012-08-22 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Structural bases of coronavirus attachment to host aminopeptidase N and its inhibition by neutralizing antibodies. Plos Pathog., 8, 2012
4E36	Crystal structure of the human Endoplasmic Reticulum Aminopeptidase 2 variant N392K 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Birtley, J.R, Saridakis, E, Pegias, P, Stratikos, E, Mavridis, I.M. 登録日 2012-03-09 公開日 2012-08-29 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (3.22 Å) 主引用文献 A common single nucleotide polymorphism in endoplasmic reticulum aminopeptidase 2 induces a specificity switch that leads to altered antigen processing. J.Immunol., 189, 2012
4FYQ	Human aminopeptidase N (CD13) 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ACETIC ACID, ... 著者 Wong, A.H, Rini, J.M. 登録日 2012-07-05 公開日 2012-09-05 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 The X-ray Crystal Structure of Human Aminopeptidase N Reveals a Novel Dimer and the Basis for Peptide Processing. J.Biol.Chem., 287, 2012
4FYT	Human aminopeptidase N (CD13) in complex with amastatin 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, AMASTATIN, ... 著者 Wong, A.H, Rini, J.M. 登録日 2012-07-05 公開日 2012-09-05 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 The X-ray Crystal Structure of Human Aminopeptidase N Reveals a Novel Dimer and the Basis for Peptide Processing. J.Biol.Chem., 287, 2012

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