3Q43

X-ray crystal structure of PfA-M1 bound to bestatin derivative 15

Summary for 3Q43

Entry DOI	10.2210/pdb3q43/pdb
Related	3Q44
Descriptor	M1 family aminopeptidase, ZINC ION, MAGNESIUM ION, ... (6 entities in total)
Functional Keywords	m1 aminopeptidase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Plasmodium falciparum FcB1/Columbia
Cellular location	Cytoplasm: O96935
Total number of polymer chains	1
Total formula weight	104743.28
Authors	McGowan, S.,Greenbaum, D.C. (deposition date: 2010-12-22, release date: 2011-03-16, Last modification date: 2023-09-13)
Primary citation	Velmourougane, G.,Harbut, M.B.,Dalal, S.,McGowan, S.,Oellig, C.A.,Meinhardt, N.,Whisstock, J.C.,Klemba, M.,Greenbaum, D.C. Synthesis of new (-)-bestatin-based inhibitor libraries reveals a novel binding mode in the s1 pocket of the essential malaria m1 metalloaminopeptidase. J.Med.Chem., 54:1655-1666, 2011 Cited by PubMed: 21366301 DOI: 10.1021/jm101227t PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation