4F5C

Crystal structure of the spike receptor binding domain of a porcine respiratory coronavirus in complex with the pig aminopeptidase N ectodomain

Summary for 4F5C

• Entry DOI: 10.2210/pdb4f5c/pdb
• Related: 4F2M
• Descriptor: Aminopeptidase N, PRCV spike protein, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• Functional Keywords: virus entry, cellular receptor, aminopeptidase n, glycosylation, virus membrane, metalloprotease, hydrolase-viral protein complex, hydrolase/viral protein
• Biological source: Sus scrofa (pig); More
• Total number of polymer chains: 4
• Total formula weight: 320353.89

Authors

Santiago, C.,Reguera, J.,Gaurav, M.,Ordono, D.,Enjuanes, L.,Casasnovas, J.M. (deposition date: 2012-05-13, release date: 2012-08-22, Last modification date: 2020-07-29)

• Primary citation: Reguera, J.,Santiago, C.,Mudgal, G.,Ordono, D.,Enjuanes, L.,Casasnovas, J.M.; Structural bases of coronavirus attachment to host aminopeptidase N and its inhibition by neutralizing antibodies.; Plos Pathog., 8:e1002859-e1002859, 2012; PubMed: 22876187; DOI: 10.1371/journal.ppat.1002859

Experimental method

X-RAY DIFFRACTION (3.2 Å)