PDB: 159 resultsInfo pagesStatus searchChemie searchBIRD

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4PKZ	Crystal structure of P1M mutant of Macrophage Migration Inhibitory Factor Descriptor: ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, SULFATE ION Authors: Pantouris, G, Lolis, E. Deposit date: 2014-05-15 Release date: 2015-09-30 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (1.9 Å) Cite: An Analysis of MIF Structural Features that Control Functional Activation of CD74. Chem.Biol., 22, 2015
4PLU	Crystal structure of Macrophage Migration Inhibitory Factor in complex with benzaldehyde Descriptor: ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, SULFATE ION, ... Authors: Pantouris, G, Lolis, E. Deposit date: 2014-05-19 Release date: 2015-09-30 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (1.63 Å) Cite: An Analysis of MIF Structural Features that Control Functional Activation of CD74. Chem.Biol., 22, 2015
4TRF	Crystal structure of Macrophage Migration Inhibitory Factor in complex with N-(pyridin-3-ylmethyl)thioformamide Descriptor: GLYCEROL, ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, ... Authors: Pantouris, G, Lolis, E. Deposit date: 2014-06-16 Release date: 2015-09-30 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (1.63 Å) Cite: An Analysis of MIF Structural Features that Control Functional Activation of CD74. Chem.Biol., 22, 2015
4TRU	Crystal structure of Q24A Q25A mutant of human macrophage migration inhibitory factor Descriptor: GLYCEROL, ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, ... Authors: Pantouris, G, Lolis, E. Deposit date: 2014-06-17 Release date: 2015-09-30 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (1.81 Å) Cite: An Analysis of MIF Structural Features that Control Functional Activation of CD74. Chem.Biol., 22, 2015
4WRB	Macrophage Migration Inhibitory Factor in complex with a biaryltriazole inhibitor (3b-190) Descriptor: 4-{4-[6-(2-methoxyethoxy)quinolin-2-yl]-1H-1,2,3-triazol-1-yl}phenol, GLYCEROL, ISOPROPYL ALCOHOL, ... Authors: Robertson, M.J, Baxter, R.H.G, Jorgensen, W.L. Deposit date: 2014-10-23 Release date: 2015-03-11 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (1.81 Å) Cite: Design, synthesis, and protein crystallography of biaryltriazoles as potent tautomerase inhibitors of macrophage migration inhibitory factor. J.Am.Chem.Soc., 137, 2015
4WR8	Macrophage Migration Inhibitory Factor in complex with a biaryltriazole inhibitor (3b-180) Descriptor: 4-[4-(quinolin-2-yl)-1H-1,2,3-triazol-1-yl]phenol, Macrophage migration inhibitory factor, SODIUM ION, ... Authors: Robertson, M.J, Baxter, R.H.G, Jorgensen, W.L. Deposit date: 2014-10-23 Release date: 2015-03-11 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Design, synthesis, and protein crystallography of biaryltriazoles as potent tautomerase inhibitors of macrophage migration inhibitory factor. J.Am.Chem.Soc., 137, 2015
4XX7	Crystal structure of M2A mutant of human macrophage migration inhibitory factor Descriptor: GLYCEROL, ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, ... Authors: Pantouris, G, Lolis, E. Deposit date: 2015-01-29 Release date: 2015-09-30 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.77 Å) Cite: An Analysis of MIF Structural Features that Control Functional Activation of CD74. Chem.Biol., 22, 2015
4XX8	Crystal structure of Pro1 deletion mutant of human macrophage migration inhibitory factor Descriptor: GLYCEROL, Macrophage migration inhibitory factor, SULFATE ION Authors: Pantouris, G, Lolis, E. Deposit date: 2015-01-30 Release date: 2015-09-30 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.77 Å) Cite: An Analysis of MIF Structural Features that Control Functional Activation of CD74. Chem.Biol., 22, 2015
4Z15	MIF in complex with 3-(2-furylmethyl)-2-thioxo-1,3-thiazolan-4-one Descriptor: ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, SULFATE ION Authors: Cho, T.Y. Deposit date: 2015-03-26 Release date: 2016-09-28 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Structural basis for decreased induction of class IB PI3-kinases expression by MIF inhibitors. J. Cell. Mol. Med., 21, 2017
4Z1T	MIF in complex with 4-[(4-oxo-2-thioxo-1,3-thiazolan-3-yl)methyl]benzonitrile Descriptor: ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, SULFATE ION Authors: Cho, T.Y. Deposit date: 2015-03-27 Release date: 2016-09-28 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Structural basis for decreased induction of class IB PI3-kinases expression by MIF inhibitors. J. Cell. Mol. Med., 21, 2017
4Z1U	MIF in complex with 1-(4-methylphenyl)-3-phenylprop-2-yn-1-one Descriptor: GLYCEROL, Macrophage migration inhibitory factor, SULFATE ION Authors: Cho, T.Y. Deposit date: 2015-03-27 Release date: 2016-09-28 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Structural basis for decreased induction of class IB PI3-kinases expression by MIF inhibitors. J. Cell. Mol. Med., 21, 2017
5BS9	Crystal structure of N109A mutant of human macrophage migration inhibitory factor Descriptor: GLYCEROL, ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, ... Authors: Pantouris, G, Lolis, E. Deposit date: 2015-06-01 Release date: 2015-09-30 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.98 Å) Cite: An Analysis of MIF Structural Features that Control Functional Activation of CD74. Chem.Biol., 22, 2015
5BSC	Crystal structure of K66A mutant of human macrophage migration inhibitory factor Descriptor: ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor Authors: Pantouris, G, Lolis, E. Deposit date: 2015-06-01 Release date: 2015-09-30 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.89 Å) Cite: An Analysis of MIF Structural Features that Control Functional Activation of CD74. Chem.Biol., 22, 2015
5BSJ	Crystal structure of S63A mutant of human macrophage migration inhibitory factor Descriptor: GLYCEROL, ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, ... Authors: Pantouris, G, Lolis, E. Deposit date: 2015-06-02 Release date: 2016-06-08 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2 Å) Cite: Crystal structure of S63A mutant of human macrophage migration inhibitory factor To Be Published
5BSI	Crystal structure of Y36A mutant of human macrophage migration inhibitory factor Descriptor: GLYCEROL, Macrophage migration inhibitory factor, SULFATE ION Authors: Pantouris, G, Lolis, E. Deposit date: 2015-06-02 Release date: 2015-09-30 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2 Å) Cite: An Analysis of MIF Structural Features that Control Functional Activation of CD74. Chem.Biol., 22, 2015
5EIZ	Crystal structure of Y99A mutant of human macrophage migration inhibitory factor Descriptor: GLYCEROL, ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, ... Authors: Pantouris, G, Lolis, E. Deposit date: 2015-10-30 Release date: 2015-11-11 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.96 Å) Cite: Nanosecond Dynamics Regulate the MIF-Induced Activity of CD74. Angew. Chem. Int. Ed. Engl., 2018
5HVS	Crystal Structure of Macrophage Migration Inhibitory Factor (MIF) with a Biaryltriazole Inhibitor (3i-305) Descriptor: 3-({2-[1-(3-fluoro-4-hydroxyphenyl)-1H-1,2,3-triazol-4-yl]quinolin-5-yl}oxy)benzoic acid, GLYCEROL, Macrophage migration inhibitory factor, ... Authors: Robertson, M.J, Jorgensen, W.L. Deposit date: 2016-01-28 Release date: 2016-06-29 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.75 Å) Cite: A Fluorescence Polarization Assay for Binding to Macrophage Migration Inhibitory Factor and Crystal Structures for Complexes of Two Potent Inhibitors. J.Am.Chem.Soc., 138, 2016
5HVT	Crystal Structure of Macrophage Migration Inhibitory Factor (MIF) with a Potent Inhibitor (NVS-2) Descriptor: 7-hydroxy-3-(4-methoxyphenyl)-3,4-dihydro-2H-1,3-benzoxazin-2-one, GLYCEROL, ISOPROPYL ALCOHOL, ... Authors: Robertson, M.J, Jorgensen, W.L. Deposit date: 2016-01-28 Release date: 2016-06-29 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.75 Å) Cite: A Fluorescence Polarization Assay for Binding to Macrophage Migration Inhibitory Factor and Crystal Structures for Complexes of Two Potent Inhibitors. J.Am.Chem.Soc., 138, 2016
5HVV	Crystal structure of Pro1 deletion and M2A double mutant of Macrophage Migration Inhibitory Factor Descriptor: ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, SULFATE ION Authors: Pantouris, G, Lolis, E. Deposit date: 2016-01-28 Release date: 2016-02-10 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Crystal structure of P1 deletion and M2A double mutant of Macrophage Migration Inhibitory Factor To Be Published
5J7P	Macrophage Migration Inhibitory Factor bound to Covalent Inhibitor RDR03785 Descriptor: 6-{[4-(trifluoromethyl)phenyl]methyl}-2H-1,3-benzodioxol-5-ol, GLYCEROL, ISOPROPYL ALCOHOL, ... Authors: Robertson, M.J, Jorgensen, W.L. Deposit date: 2016-04-06 Release date: 2016-05-04 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Irregularities in enzyme assays: The case of macrophage migration inhibitory factor. Bioorg.Med.Chem.Lett., 26, 2016
5J7Q	Macrophage Migration Inhibitory Factor bound to Inhibitor K664 Derivative Descriptor: 4-(imidazo[1,2-a]pyridin-2-yl)benzene-1,2-diol, GLYCEROL, ISOPROPYL ALCOHOL, ... Authors: Robertson, M.J, Jorgensen, W.L. Deposit date: 2016-04-06 Release date: 2016-05-04 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Irregularities in enzyme assays: The case of macrophage migration inhibitory factor. Bioorg.Med.Chem.Lett., 26, 2016
5B4O	Crystal structure of Macrophage Migration Inhibitory Factor in complex with BTZO-14 Descriptor: 1,2-ETHANEDIOL, 2-pyridin-3-yl-1,3-benzothiazin-4-one, Macrophage migration inhibitory factor, ... Authors: Oki, H, Igaki, S, Moriya, Y, Hayano, Y, Habuka, N. Deposit date: 2016-04-07 Release date: 2016-04-20 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.37 Å) Cite: BTZO-1, a cardioprotective agent, reveals that macrophage migration inhibitory factor regulates ARE-mediated gene expression Chem. Biol., 17, 2010
5UMK	Crystal structure of H62Y mutant of human macrophage migration inhibitory factor Descriptor: GLYCEROL, ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, ... Authors: Pantouris, G, Lolis, E. Deposit date: 2017-01-27 Release date: 2018-02-07 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.73 Å) Cite: Regulation of MIF Enzymatic Activity by an Allosteric Site at the Central Solvent Channel. Cell Chem Biol, 27, 2020
5UMJ	Crystal structure of H62A mutant of human macrophage migration inhibitory factor Descriptor: ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, SULFATE ION Authors: Pantouris, G, Lolis, E. Deposit date: 2017-01-27 Release date: 2018-02-07 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.61 Å) Cite: Regulation of MIF Enzymatic Activity by an Allosteric Site at the Central Solvent Channel. Cell Chem Biol, 27, 2020
5UZY	Crystal structure of N97A mutant of human macrophage migration inhibitory factor Descriptor: GLYCEROL, ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, ... Authors: Pantouris, G, Lolis, E. Deposit date: 2017-02-27 Release date: 2018-02-28 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.71 Å) Cite: Nanosecond Dynamics Regulate the MIF-Induced Activity of CD74. Angew. Chem. Int. Ed. Engl., 57, 2018

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