5HVT

Crystal Structure of Macrophage Migration Inhibitory Factor (MIF) with a Potent Inhibitor (NVS-2)

Summary for 5HVT

Entry DOI	10.2210/pdb5hvt/pdb
Related	5HVS
Descriptor	Macrophage migration inhibitory factor, SULFATE ION, 7-hydroxy-3-(4-methoxyphenyl)-3,4-dihydro-2H-1,3-benzoxazin-2-one, ... (6 entities in total)
Functional Keywords	cytokine, inhibitor, complex, isomerase-isomerase inhibitor complex, isomerase/isomerase inhibitor
Biological source	Homo sapiens (Human)
Cellular location	Secreted : P14174
Total number of polymer chains	3
Total formula weight	38911.92
Authors	Robertson, M.J.,Jorgensen, W.L. (deposition date: 2016-01-28, release date: 2016-06-29, Last modification date: 2023-09-27)
Primary citation	Cisneros, J.A.,Robertson, M.J.,Valhondo, M.,Jorgensen, W.L. A Fluorescence Polarization Assay for Binding to Macrophage Migration Inhibitory Factor and Crystal Structures for Complexes of Two Potent Inhibitors. J.Am.Chem.Soc., 138:8630-8638, 2016 Cited by PubMed: 27299179 DOI: 10.1021/jacs.6b04910 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.75 Å)

Structure validation