4Z15
MIF in complex with 3-(2-furylmethyl)-2-thioxo-1,3-thiazolan-4-one
Summary for 4Z15
| Entry DOI | 10.2210/pdb4z15/pdb |
| Related | 4Z1T 4Z1U |
| Descriptor | Macrophage migration inhibitory factor, ISOPROPYL ALCOHOL, SULFATE ION, ... (4 entities in total) |
| Functional Keywords | covalent inhibitor, protein surface modification, isomerase-isomerase inhibitor complex, isomerase/isomerase inhibitor |
| Biological source | Homo sapiens (Human) |
| Cellular location | Secreted : P14174 |
| Total number of polymer chains | 3 |
| Total formula weight | 37830.97 |
| Authors | Cho, T.Y. (deposition date: 2015-03-26, release date: 2016-09-28, Last modification date: 2023-09-27) |
| Primary citation | Singh, A.K.,Pantouris, G.,Borosch, S.,Rojanasthien, S.,Cho, T.Y. Structural basis for decreased induction of class IB PI3-kinases expression by MIF inhibitors. J. Cell. Mol. Med., 21:142-153, 2017 Cited by PubMed: 27619729DOI: 10.1111/jcmm.12949 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
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