4WR8
Macrophage Migration Inhibitory Factor in complex with a biaryltriazole inhibitor (3b-180)
Summary for 4WR8
Entry DOI | 10.2210/pdb4wr8/pdb |
Related | 4WRB |
Descriptor | Macrophage migration inhibitory factor, SULFATE ION, 4-[4-(quinolin-2-yl)-1H-1,2,3-triazol-1-yl]phenol, ... (5 entities in total) |
Functional Keywords | cd74 binding, tautomerase, inhibitor, complex, isomerase-isomerase inhibitor complex, isomerase/isomerase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 18 |
Total formula weight | 229281.14 |
Authors | Robertson, M.J.,Baxter, R.H.G.,Jorgensen, W.L. (deposition date: 2014-10-23, release date: 2015-03-11, Last modification date: 2023-12-27) |
Primary citation | Dziedzic, P.,Cisneros, J.A.,Robertson, M.J.,Hare, A.A.,Danford, N.E.,Baxter, R.H.,Jorgensen, W.L. Design, synthesis, and protein crystallography of biaryltriazoles as potent tautomerase inhibitors of macrophage migration inhibitory factor. J.Am.Chem.Soc., 137:2996-3003, 2015 Cited by PubMed: 25697265DOI: 10.1021/ja512112j PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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