4WR8

Macrophage Migration Inhibitory Factor in complex with a biaryltriazole inhibitor (3b-180)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001516	biological_process	prostaglandin biosynthetic process
A	0001819	biological_process	positive regulation of cytokine production
A	0002020	molecular_function	protease binding
A	0002376	biological_process	immune system process
A	0002906	biological_process	negative regulation of mature B cell apoptotic process
A	0004167	molecular_function	dopachrome isomerase activity
A	0005125	molecular_function	cytokine activity
A	0005126	molecular_function	cytokine receptor binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006954	biological_process	inflammatory response
A	0007166	biological_process	cell surface receptor signaling pathway
A	0008284	biological_process	positive regulation of cell population proliferation
A	0009986	cellular_component	cell surface
A	0010629	biological_process	negative regulation of gene expression
A	0010760	biological_process	negative regulation of macrophage chemotaxis
A	0016853	molecular_function	isomerase activity
A	0019752	biological_process	carboxylic acid metabolic process
A	0030336	biological_process	negative regulation of cell migration
A	0030890	biological_process	positive regulation of B cell proliferation
A	0031666	biological_process	positive regulation of lipopolysaccharide-mediated signaling pathway
A	0031982	cellular_component	vesicle
A	0032760	biological_process	positive regulation of tumor necrosis factor production
A	0033033	biological_process	negative regulation of myeloid cell apoptotic process
A	0034774	cellular_component	secretory granule lumen
A	0042056	molecular_function	chemoattractant activity
A	0042327	biological_process	positive regulation of phosphorylation
A	0042802	molecular_function	identical protein binding
A	0043030	biological_process	regulation of macrophage activation
A	0043066	biological_process	negative regulation of apoptotic process
A	0043518	biological_process	negative regulation of DNA damage response, signal transduction by p53 class mediator
A	0045087	biological_process	innate immune response
A	0048146	biological_process	positive regulation of fibroblast proliferation
A	0050178	molecular_function	phenylpyruvate tautomerase activity
A	0050918	biological_process	positive chemotaxis
A	0051248	biological_process	negative regulation of protein metabolic process
A	0061078	biological_process	obsolete positive regulation of prostaglandin secretion involved in immune response
A	0061081	biological_process	positive regulation of myeloid leukocyte cytokine production involved in immune response
A	0070062	cellular_component	extracellular exosome
A	0070207	biological_process	protein homotrimerization
A	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
A	0080135	biological_process	regulation of cellular response to stress
A	0090238	biological_process	positive regulation of arachidonate secretion
A	0141163	biological_process	positive regulation of cAMP/PKA signal transduction
A	1902166	biological_process	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
A	1904813	cellular_component	ficolin-1-rich granule lumen
A	2000343	biological_process	positive regulation of chemokine (C-X-C motif) ligand 2 production
A	2000773	biological_process	negative regulation of cellular senescence
B	0001516	biological_process	prostaglandin biosynthetic process
B	0001819	biological_process	positive regulation of cytokine production
B	0002020	molecular_function	protease binding
B	0002376	biological_process	immune system process
B	0002906	biological_process	negative regulation of mature B cell apoptotic process
B	0004167	molecular_function	dopachrome isomerase activity
B	0005125	molecular_function	cytokine activity
B	0005126	molecular_function	cytokine receptor binding
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0006954	biological_process	inflammatory response
B	0007166	biological_process	cell surface receptor signaling pathway
B	0008284	biological_process	positive regulation of cell population proliferation
B	0009986	cellular_component	cell surface
B	0010629	biological_process	negative regulation of gene expression
B	0010760	biological_process	negative regulation of macrophage chemotaxis
B	0016853	molecular_function	isomerase activity
B	0019752	biological_process	carboxylic acid metabolic process
B	0030336	biological_process	negative regulation of cell migration
B	0030890	biological_process	positive regulation of B cell proliferation
B	0031666	biological_process	positive regulation of lipopolysaccharide-mediated signaling pathway
B	0031982	cellular_component	vesicle
B	0032760	biological_process	positive regulation of tumor necrosis factor production
B	0033033	biological_process	negative regulation of myeloid cell apoptotic process
B	0034774	cellular_component	secretory granule lumen
B	0042056	molecular_function	chemoattractant activity
B	0042327	biological_process	positive regulation of phosphorylation
B	0042802	molecular_function	identical protein binding
B	0043030	biological_process	regulation of macrophage activation
B	0043066	biological_process	negative regulation of apoptotic process
B	0043518	biological_process	negative regulation of DNA damage response, signal transduction by p53 class mediator
B	0045087	biological_process	innate immune response
B	0048146	biological_process	positive regulation of fibroblast proliferation
B	0050178	molecular_function	phenylpyruvate tautomerase activity
B	0050918	biological_process	positive chemotaxis
B	0051248	biological_process	negative regulation of protein metabolic process
B	0061078	biological_process	obsolete positive regulation of prostaglandin secretion involved in immune response
B	0061081	biological_process	positive regulation of myeloid leukocyte cytokine production involved in immune response
B	0070062	cellular_component	extracellular exosome
B	0070207	biological_process	protein homotrimerization
B	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
B	0080135	biological_process	regulation of cellular response to stress
B	0090238	biological_process	positive regulation of arachidonate secretion
B	0141163	biological_process	positive regulation of cAMP/PKA signal transduction
B	1902166	biological_process	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
B	1904813	cellular_component	ficolin-1-rich granule lumen
B	2000343	biological_process	positive regulation of chemokine (C-X-C motif) ligand 2 production
B	2000773	biological_process	negative regulation of cellular senescence
C	0001516	biological_process	prostaglandin biosynthetic process
C	0001819	biological_process	positive regulation of cytokine production
C	0002020	molecular_function	protease binding
C	0002376	biological_process	immune system process
C	0002906	biological_process	negative regulation of mature B cell apoptotic process
C	0004167	molecular_function	dopachrome isomerase activity
C	0005125	molecular_function	cytokine activity
C	0005126	molecular_function	cytokine receptor binding
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0006954	biological_process	inflammatory response
C	0007166	biological_process	cell surface receptor signaling pathway
C	0008284	biological_process	positive regulation of cell population proliferation
C	0009986	cellular_component	cell surface
C	0010629	biological_process	negative regulation of gene expression
C	0010760	biological_process	negative regulation of macrophage chemotaxis
C	0016853	molecular_function	isomerase activity
C	0019752	biological_process	carboxylic acid metabolic process
C	0030336	biological_process	negative regulation of cell migration
C	0030890	biological_process	positive regulation of B cell proliferation
C	0031666	biological_process	positive regulation of lipopolysaccharide-mediated signaling pathway
C	0031982	cellular_component	vesicle
C	0032760	biological_process	positive regulation of tumor necrosis factor production
C	0033033	biological_process	negative regulation of myeloid cell apoptotic process
C	0034774	cellular_component	secretory granule lumen
C	0042056	molecular_function	chemoattractant activity
C	0042327	biological_process	positive regulation of phosphorylation
C	0042802	molecular_function	identical protein binding
C	0043030	biological_process	regulation of macrophage activation
C	0043066	biological_process	negative regulation of apoptotic process
C	0043518	biological_process	negative regulation of DNA damage response, signal transduction by p53 class mediator
C	0045087	biological_process	innate immune response
C	0048146	biological_process	positive regulation of fibroblast proliferation
C	0050178	molecular_function	phenylpyruvate tautomerase activity
C	0050918	biological_process	positive chemotaxis
C	0051248	biological_process	negative regulation of protein metabolic process
C	0061078	biological_process	obsolete positive regulation of prostaglandin secretion involved in immune response
C	0061081	biological_process	positive regulation of myeloid leukocyte cytokine production involved in immune response
C	0070062	cellular_component	extracellular exosome
C	0070207	biological_process	protein homotrimerization
C	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
C	0080135	biological_process	regulation of cellular response to stress
C	0090238	biological_process	positive regulation of arachidonate secretion
C	0141163	biological_process	positive regulation of cAMP/PKA signal transduction
C	1902166	biological_process	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
C	1904813	cellular_component	ficolin-1-rich granule lumen
C	2000343	biological_process	positive regulation of chemokine (C-X-C motif) ligand 2 production
C	2000773	biological_process	negative regulation of cellular senescence
D	0001516	biological_process	prostaglandin biosynthetic process
D	0001819	biological_process	positive regulation of cytokine production
D	0002020	molecular_function	protease binding
D	0002376	biological_process	immune system process
D	0002906	biological_process	negative regulation of mature B cell apoptotic process
D	0004167	molecular_function	dopachrome isomerase activity
D	0005125	molecular_function	cytokine activity
D	0005126	molecular_function	cytokine receptor binding
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0006954	biological_process	inflammatory response
D	0007166	biological_process	cell surface receptor signaling pathway
D	0008284	biological_process	positive regulation of cell population proliferation
D	0009986	cellular_component	cell surface
D	0010629	biological_process	negative regulation of gene expression
D	0010760	biological_process	negative regulation of macrophage chemotaxis
D	0016853	molecular_function	isomerase activity
D	0019752	biological_process	carboxylic acid metabolic process
D	0030336	biological_process	negative regulation of cell migration
D	0030890	biological_process	positive regulation of B cell proliferation
D	0031666	biological_process	positive regulation of lipopolysaccharide-mediated signaling pathway
D	0031982	cellular_component	vesicle
D	0032760	biological_process	positive regulation of tumor necrosis factor production
D	0033033	biological_process	negative regulation of myeloid cell apoptotic process
D	0034774	cellular_component	secretory granule lumen
D	0042056	molecular_function	chemoattractant activity
D	0042327	biological_process	positive regulation of phosphorylation
D	0042802	molecular_function	identical protein binding
D	0043030	biological_process	regulation of macrophage activation
D	0043066	biological_process	negative regulation of apoptotic process
D	0043518	biological_process	negative regulation of DNA damage response, signal transduction by p53 class mediator
D	0045087	biological_process	innate immune response
D	0048146	biological_process	positive regulation of fibroblast proliferation
D	0050178	molecular_function	phenylpyruvate tautomerase activity
D	0050918	biological_process	positive chemotaxis
D	0051248	biological_process	negative regulation of protein metabolic process
D	0061078	biological_process	obsolete positive regulation of prostaglandin secretion involved in immune response
D	0061081	biological_process	positive regulation of myeloid leukocyte cytokine production involved in immune response
D	0070062	cellular_component	extracellular exosome
D	0070207	biological_process	protein homotrimerization
D	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
D	0080135	biological_process	regulation of cellular response to stress
D	0090238	biological_process	positive regulation of arachidonate secretion
D	0141163	biological_process	positive regulation of cAMP/PKA signal transduction
D	1902166	biological_process	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
D	1904813	cellular_component	ficolin-1-rich granule lumen
D	2000343	biological_process	positive regulation of chemokine (C-X-C motif) ligand 2 production
D	2000773	biological_process	negative regulation of cellular senescence
E	0001516	biological_process	prostaglandin biosynthetic process
E	0001819	biological_process	positive regulation of cytokine production
E	0002020	molecular_function	protease binding
E	0002376	biological_process	immune system process
E	0002906	biological_process	negative regulation of mature B cell apoptotic process
E	0004167	molecular_function	dopachrome isomerase activity
E	0005125	molecular_function	cytokine activity
E	0005126	molecular_function	cytokine receptor binding
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0005886	cellular_component	plasma membrane
E	0006954	biological_process	inflammatory response
E	0007166	biological_process	cell surface receptor signaling pathway
E	0008284	biological_process	positive regulation of cell population proliferation
E	0009986	cellular_component	cell surface
E	0010629	biological_process	negative regulation of gene expression
E	0010760	biological_process	negative regulation of macrophage chemotaxis
E	0016853	molecular_function	isomerase activity
E	0019752	biological_process	carboxylic acid metabolic process
E	0030336	biological_process	negative regulation of cell migration
E	0030890	biological_process	positive regulation of B cell proliferation
E	0031666	biological_process	positive regulation of lipopolysaccharide-mediated signaling pathway
E	0031982	cellular_component	vesicle
E	0032760	biological_process	positive regulation of tumor necrosis factor production
E	0033033	biological_process	negative regulation of myeloid cell apoptotic process
E	0034774	cellular_component	secretory granule lumen
E	0042056	molecular_function	chemoattractant activity
E	0042327	biological_process	positive regulation of phosphorylation
E	0042802	molecular_function	identical protein binding
E	0043030	biological_process	regulation of macrophage activation
E	0043066	biological_process	negative regulation of apoptotic process
E	0043518	biological_process	negative regulation of DNA damage response, signal transduction by p53 class mediator
E	0045087	biological_process	innate immune response
E	0048146	biological_process	positive regulation of fibroblast proliferation
E	0050178	molecular_function	phenylpyruvate tautomerase activity
E	0050918	biological_process	positive chemotaxis
E	0051248	biological_process	negative regulation of protein metabolic process
E	0061078	biological_process	obsolete positive regulation of prostaglandin secretion involved in immune response
E	0061081	biological_process	positive regulation of myeloid leukocyte cytokine production involved in immune response
E	0070062	cellular_component	extracellular exosome
E	0070207	biological_process	protein homotrimerization
E	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
E	0080135	biological_process	regulation of cellular response to stress
E	0090238	biological_process	positive regulation of arachidonate secretion
E	0141163	biological_process	positive regulation of cAMP/PKA signal transduction
E	1902166	biological_process	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
E	1904813	cellular_component	ficolin-1-rich granule lumen
E	2000343	biological_process	positive regulation of chemokine (C-X-C motif) ligand 2 production
E	2000773	biological_process	negative regulation of cellular senescence
F	0001516	biological_process	prostaglandin biosynthetic process
F	0001819	biological_process	positive regulation of cytokine production
F	0002020	molecular_function	protease binding
F	0002376	biological_process	immune system process
F	0002906	biological_process	negative regulation of mature B cell apoptotic process
F	0004167	molecular_function	dopachrome isomerase activity
F	0005125	molecular_function	cytokine activity
F	0005126	molecular_function	cytokine receptor binding
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005615	cellular_component	extracellular space
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0005886	cellular_component	plasma membrane
F	0006954	biological_process	inflammatory response
F	0007166	biological_process	cell surface receptor signaling pathway
F	0008284	biological_process	positive regulation of cell population proliferation
F	0009986	cellular_component	cell surface
F	0010629	biological_process	negative regulation of gene expression
F	0010760	biological_process	negative regulation of macrophage chemotaxis
F	0016853	molecular_function	isomerase activity
F	0019752	biological_process	carboxylic acid metabolic process
F	0030336	biological_process	negative regulation of cell migration
F	0030890	biological_process	positive regulation of B cell proliferation
F	0031666	biological_process	positive regulation of lipopolysaccharide-mediated signaling pathway
F	0031982	cellular_component	vesicle
F	0032760	biological_process	positive regulation of tumor necrosis factor production
F	0033033	biological_process	negative regulation of myeloid cell apoptotic process
F	0034774	cellular_component	secretory granule lumen
F	0042056	molecular_function	chemoattractant activity
F	0042327	biological_process	positive regulation of phosphorylation
F	0042802	molecular_function	identical protein binding
F	0043030	biological_process	regulation of macrophage activation
F	0043066	biological_process	negative regulation of apoptotic process
F	0043518	biological_process	negative regulation of DNA damage response, signal transduction by p53 class mediator
F	0045087	biological_process	innate immune response
F	0048146	biological_process	positive regulation of fibroblast proliferation
F	0050178	molecular_function	phenylpyruvate tautomerase activity
F	0050918	biological_process	positive chemotaxis
F	0051248	biological_process	negative regulation of protein metabolic process
F	0061078	biological_process	obsolete positive regulation of prostaglandin secretion involved in immune response
F	0061081	biological_process	positive regulation of myeloid leukocyte cytokine production involved in immune response
F	0070062	cellular_component	extracellular exosome
F	0070207	biological_process	protein homotrimerization
F	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
F	0080135	biological_process	regulation of cellular response to stress
F	0090238	biological_process	positive regulation of arachidonate secretion
F	0141163	biological_process	positive regulation of cAMP/PKA signal transduction
F	1902166	biological_process	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
F	1904813	cellular_component	ficolin-1-rich granule lumen
F	2000343	biological_process	positive regulation of chemokine (C-X-C motif) ligand 2 production
F	2000773	biological_process	negative regulation of cellular senescence
G	0001516	biological_process	prostaglandin biosynthetic process
G	0001819	biological_process	positive regulation of cytokine production
G	0002020	molecular_function	protease binding
G	0002376	biological_process	immune system process
G	0002906	biological_process	negative regulation of mature B cell apoptotic process
G	0004167	molecular_function	dopachrome isomerase activity
G	0005125	molecular_function	cytokine activity
G	0005126	molecular_function	cytokine receptor binding
G	0005515	molecular_function	protein binding
G	0005576	cellular_component	extracellular region
G	0005615	cellular_component	extracellular space
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0005886	cellular_component	plasma membrane
G	0006954	biological_process	inflammatory response
G	0007166	biological_process	cell surface receptor signaling pathway
G	0008284	biological_process	positive regulation of cell population proliferation
G	0009986	cellular_component	cell surface
G	0010629	biological_process	negative regulation of gene expression
G	0010760	biological_process	negative regulation of macrophage chemotaxis
G	0016853	molecular_function	isomerase activity
G	0019752	biological_process	carboxylic acid metabolic process
G	0030336	biological_process	negative regulation of cell migration
G	0030890	biological_process	positive regulation of B cell proliferation
G	0031666	biological_process	positive regulation of lipopolysaccharide-mediated signaling pathway
G	0031982	cellular_component	vesicle
G	0032760	biological_process	positive regulation of tumor necrosis factor production
G	0033033	biological_process	negative regulation of myeloid cell apoptotic process
G	0034774	cellular_component	secretory granule lumen
G	0042056	molecular_function	chemoattractant activity
G	0042327	biological_process	positive regulation of phosphorylation
G	0042802	molecular_function	identical protein binding
G	0043030	biological_process	regulation of macrophage activation
G	0043066	biological_process	negative regulation of apoptotic process
G	0043518	biological_process	negative regulation of DNA damage response, signal transduction by p53 class mediator
G	0045087	biological_process	innate immune response
G	0048146	biological_process	positive regulation of fibroblast proliferation
G	0050178	molecular_function	phenylpyruvate tautomerase activity
G	0050918	biological_process	positive chemotaxis
G	0051248	biological_process	negative regulation of protein metabolic process
G	0061078	biological_process	obsolete positive regulation of prostaglandin secretion involved in immune response
G	0061081	biological_process	positive regulation of myeloid leukocyte cytokine production involved in immune response
G	0070062	cellular_component	extracellular exosome
G	0070207	biological_process	protein homotrimerization
G	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
G	0080135	biological_process	regulation of cellular response to stress
G	0090238	biological_process	positive regulation of arachidonate secretion
G	0141163	biological_process	positive regulation of cAMP/PKA signal transduction
G	1902166	biological_process	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
G	1904813	cellular_component	ficolin-1-rich granule lumen
G	2000343	biological_process	positive regulation of chemokine (C-X-C motif) ligand 2 production
G	2000773	biological_process	negative regulation of cellular senescence
H	0001516	biological_process	prostaglandin biosynthetic process
H	0001819	biological_process	positive regulation of cytokine production
H	0002020	molecular_function	protease binding
H	0002376	biological_process	immune system process
H	0002906	biological_process	negative regulation of mature B cell apoptotic process
H	0004167	molecular_function	dopachrome isomerase activity
H	0005125	molecular_function	cytokine activity
H	0005126	molecular_function	cytokine receptor binding
H	0005515	molecular_function	protein binding
H	0005576	cellular_component	extracellular region
H	0005615	cellular_component	extracellular space
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0005886	cellular_component	plasma membrane
H	0006954	biological_process	inflammatory response
H	0007166	biological_process	cell surface receptor signaling pathway
H	0008284	biological_process	positive regulation of cell population proliferation
H	0009986	cellular_component	cell surface
H	0010629	biological_process	negative regulation of gene expression
H	0010760	biological_process	negative regulation of macrophage chemotaxis
H	0016853	molecular_function	isomerase activity
H	0019752	biological_process	carboxylic acid metabolic process
H	0030336	biological_process	negative regulation of cell migration
H	0030890	biological_process	positive regulation of B cell proliferation
H	0031666	biological_process	positive regulation of lipopolysaccharide-mediated signaling pathway
H	0031982	cellular_component	vesicle
H	0032760	biological_process	positive regulation of tumor necrosis factor production
H	0033033	biological_process	negative regulation of myeloid cell apoptotic process
H	0034774	cellular_component	secretory granule lumen
H	0042056	molecular_function	chemoattractant activity
H	0042327	biological_process	positive regulation of phosphorylation
H	0042802	molecular_function	identical protein binding
H	0043030	biological_process	regulation of macrophage activation
H	0043066	biological_process	negative regulation of apoptotic process
H	0043518	biological_process	negative regulation of DNA damage response, signal transduction by p53 class mediator
H	0045087	biological_process	innate immune response
H	0048146	biological_process	positive regulation of fibroblast proliferation
H	0050178	molecular_function	phenylpyruvate tautomerase activity
H	0050918	biological_process	positive chemotaxis
H	0051248	biological_process	negative regulation of protein metabolic process
H	0061078	biological_process	obsolete positive regulation of prostaglandin secretion involved in immune response
H	0061081	biological_process	positive regulation of myeloid leukocyte cytokine production involved in immune response
H	0070062	cellular_component	extracellular exosome
H	0070207	biological_process	protein homotrimerization
H	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
H	0080135	biological_process	regulation of cellular response to stress
H	0090238	biological_process	positive regulation of arachidonate secretion
H	0141163	biological_process	positive regulation of cAMP/PKA signal transduction
H	1902166	biological_process	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
H	1904813	cellular_component	ficolin-1-rich granule lumen
H	2000343	biological_process	positive regulation of chemokine (C-X-C motif) ligand 2 production
H	2000773	biological_process	negative regulation of cellular senescence
I	0001516	biological_process	prostaglandin biosynthetic process
I	0001819	biological_process	positive regulation of cytokine production
I	0002020	molecular_function	protease binding
I	0002376	biological_process	immune system process
I	0002906	biological_process	negative regulation of mature B cell apoptotic process
I	0004167	molecular_function	dopachrome isomerase activity
I	0005125	molecular_function	cytokine activity
I	0005126	molecular_function	cytokine receptor binding
I	0005515	molecular_function	protein binding
I	0005576	cellular_component	extracellular region
I	0005615	cellular_component	extracellular space
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0005886	cellular_component	plasma membrane
I	0006954	biological_process	inflammatory response
I	0007166	biological_process	cell surface receptor signaling pathway
I	0008284	biological_process	positive regulation of cell population proliferation
I	0009986	cellular_component	cell surface
I	0010629	biological_process	negative regulation of gene expression
I	0010760	biological_process	negative regulation of macrophage chemotaxis
I	0016853	molecular_function	isomerase activity
I	0019752	biological_process	carboxylic acid metabolic process
I	0030336	biological_process	negative regulation of cell migration
I	0030890	biological_process	positive regulation of B cell proliferation
I	0031666	biological_process	positive regulation of lipopolysaccharide-mediated signaling pathway
I	0031982	cellular_component	vesicle
I	0032760	biological_process	positive regulation of tumor necrosis factor production
I	0033033	biological_process	negative regulation of myeloid cell apoptotic process
I	0034774	cellular_component	secretory granule lumen
I	0042056	molecular_function	chemoattractant activity
I	0042327	biological_process	positive regulation of phosphorylation
I	0042802	molecular_function	identical protein binding
I	0043030	biological_process	regulation of macrophage activation
I	0043066	biological_process	negative regulation of apoptotic process
I	0043518	biological_process	negative regulation of DNA damage response, signal transduction by p53 class mediator
I	0045087	biological_process	innate immune response
I	0048146	biological_process	positive regulation of fibroblast proliferation
I	0050178	molecular_function	phenylpyruvate tautomerase activity
I	0050918	biological_process	positive chemotaxis
I	0051248	biological_process	negative regulation of protein metabolic process
I	0061078	biological_process	obsolete positive regulation of prostaglandin secretion involved in immune response
I	0061081	biological_process	positive regulation of myeloid leukocyte cytokine production involved in immune response
I	0070062	cellular_component	extracellular exosome
I	0070207	biological_process	protein homotrimerization
I	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
I	0080135	biological_process	regulation of cellular response to stress
I	0090238	biological_process	positive regulation of arachidonate secretion
I	0141163	biological_process	positive regulation of cAMP/PKA signal transduction
I	1902166	biological_process	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
I	1904813	cellular_component	ficolin-1-rich granule lumen
I	2000343	biological_process	positive regulation of chemokine (C-X-C motif) ligand 2 production
I	2000773	biological_process	negative regulation of cellular senescence
J	0001516	biological_process	prostaglandin biosynthetic process
J	0001819	biological_process	positive regulation of cytokine production
J	0002020	molecular_function	protease binding
J	0002376	biological_process	immune system process
J	0002906	biological_process	negative regulation of mature B cell apoptotic process
J	0004167	molecular_function	dopachrome isomerase activity
J	0005125	molecular_function	cytokine activity
J	0005126	molecular_function	cytokine receptor binding
J	0005515	molecular_function	protein binding
J	0005576	cellular_component	extracellular region
J	0005615	cellular_component	extracellular space
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0005886	cellular_component	plasma membrane
J	0006954	biological_process	inflammatory response
J	0007166	biological_process	cell surface receptor signaling pathway
J	0008284	biological_process	positive regulation of cell population proliferation
J	0009986	cellular_component	cell surface
J	0010629	biological_process	negative regulation of gene expression
J	0010760	biological_process	negative regulation of macrophage chemotaxis
J	0016853	molecular_function	isomerase activity
J	0019752	biological_process	carboxylic acid metabolic process
J	0030336	biological_process	negative regulation of cell migration
J	0030890	biological_process	positive regulation of B cell proliferation
J	0031666	biological_process	positive regulation of lipopolysaccharide-mediated signaling pathway
J	0031982	cellular_component	vesicle
J	0032760	biological_process	positive regulation of tumor necrosis factor production
J	0033033	biological_process	negative regulation of myeloid cell apoptotic process
J	0034774	cellular_component	secretory granule lumen
J	0042056	molecular_function	chemoattractant activity
J	0042327	biological_process	positive regulation of phosphorylation
J	0042802	molecular_function	identical protein binding
J	0043030	biological_process	regulation of macrophage activation
J	0043066	biological_process	negative regulation of apoptotic process
J	0043518	biological_process	negative regulation of DNA damage response, signal transduction by p53 class mediator
J	0045087	biological_process	innate immune response
J	0048146	biological_process	positive regulation of fibroblast proliferation
J	0050178	molecular_function	phenylpyruvate tautomerase activity
J	0050918	biological_process	positive chemotaxis
J	0051248	biological_process	negative regulation of protein metabolic process
J	0061078	biological_process	obsolete positive regulation of prostaglandin secretion involved in immune response
J	0061081	biological_process	positive regulation of myeloid leukocyte cytokine production involved in immune response
J	0070062	cellular_component	extracellular exosome
J	0070207	biological_process	protein homotrimerization
J	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
J	0080135	biological_process	regulation of cellular response to stress
J	0090238	biological_process	positive regulation of arachidonate secretion
J	0141163	biological_process	positive regulation of cAMP/PKA signal transduction
J	1902166	biological_process	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
J	1904813	cellular_component	ficolin-1-rich granule lumen
J	2000343	biological_process	positive regulation of chemokine (C-X-C motif) ligand 2 production
J	2000773	biological_process	negative regulation of cellular senescence
K	0001516	biological_process	prostaglandin biosynthetic process
K	0001819	biological_process	positive regulation of cytokine production
K	0002020	molecular_function	protease binding
K	0002376	biological_process	immune system process
K	0002906	biological_process	negative regulation of mature B cell apoptotic process
K	0004167	molecular_function	dopachrome isomerase activity
K	0005125	molecular_function	cytokine activity
K	0005126	molecular_function	cytokine receptor binding
K	0005515	molecular_function	protein binding
K	0005576	cellular_component	extracellular region
K	0005615	cellular_component	extracellular space
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0005886	cellular_component	plasma membrane
K	0006954	biological_process	inflammatory response
K	0007166	biological_process	cell surface receptor signaling pathway
K	0008284	biological_process	positive regulation of cell population proliferation
K	0009986	cellular_component	cell surface
K	0010629	biological_process	negative regulation of gene expression
K	0010760	biological_process	negative regulation of macrophage chemotaxis
K	0016853	molecular_function	isomerase activity
K	0019752	biological_process	carboxylic acid metabolic process
K	0030336	biological_process	negative regulation of cell migration
K	0030890	biological_process	positive regulation of B cell proliferation
K	0031666	biological_process	positive regulation of lipopolysaccharide-mediated signaling pathway
K	0031982	cellular_component	vesicle
K	0032760	biological_process	positive regulation of tumor necrosis factor production
K	0033033	biological_process	negative regulation of myeloid cell apoptotic process
K	0034774	cellular_component	secretory granule lumen
K	0042056	molecular_function	chemoattractant activity
K	0042327	biological_process	positive regulation of phosphorylation
K	0042802	molecular_function	identical protein binding
K	0043030	biological_process	regulation of macrophage activation
K	0043066	biological_process	negative regulation of apoptotic process
K	0043518	biological_process	negative regulation of DNA damage response, signal transduction by p53 class mediator
K	0045087	biological_process	innate immune response
K	0048146	biological_process	positive regulation of fibroblast proliferation
K	0050178	molecular_function	phenylpyruvate tautomerase activity
K	0050918	biological_process	positive chemotaxis
K	0051248	biological_process	negative regulation of protein metabolic process
K	0061078	biological_process	obsolete positive regulation of prostaglandin secretion involved in immune response
K	0061081	biological_process	positive regulation of myeloid leukocyte cytokine production involved in immune response
K	0070062	cellular_component	extracellular exosome
K	0070207	biological_process	protein homotrimerization
K	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
K	0080135	biological_process	regulation of cellular response to stress
K	0090238	biological_process	positive regulation of arachidonate secretion
K	0141163	biological_process	positive regulation of cAMP/PKA signal transduction
K	1902166	biological_process	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
K	1904813	cellular_component	ficolin-1-rich granule lumen
K	2000343	biological_process	positive regulation of chemokine (C-X-C motif) ligand 2 production
K	2000773	biological_process	negative regulation of cellular senescence
L	0001516	biological_process	prostaglandin biosynthetic process
L	0001819	biological_process	positive regulation of cytokine production
L	0002020	molecular_function	protease binding
L	0002376	biological_process	immune system process
L	0002906	biological_process	negative regulation of mature B cell apoptotic process
L	0004167	molecular_function	dopachrome isomerase activity
L	0005125	molecular_function	cytokine activity
L	0005126	molecular_function	cytokine receptor binding
L	0005515	molecular_function	protein binding
L	0005576	cellular_component	extracellular region
L	0005615	cellular_component	extracellular space
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0005886	cellular_component	plasma membrane
L	0006954	biological_process	inflammatory response
L	0007166	biological_process	cell surface receptor signaling pathway
L	0008284	biological_process	positive regulation of cell population proliferation
L	0009986	cellular_component	cell surface
L	0010629	biological_process	negative regulation of gene expression
L	0010760	biological_process	negative regulation of macrophage chemotaxis
L	0016853	molecular_function	isomerase activity
L	0019752	biological_process	carboxylic acid metabolic process
L	0030336	biological_process	negative regulation of cell migration
L	0030890	biological_process	positive regulation of B cell proliferation
L	0031666	biological_process	positive regulation of lipopolysaccharide-mediated signaling pathway
L	0031982	cellular_component	vesicle
L	0032760	biological_process	positive regulation of tumor necrosis factor production
L	0033033	biological_process	negative regulation of myeloid cell apoptotic process
L	0034774	cellular_component	secretory granule lumen
L	0042056	molecular_function	chemoattractant activity
L	0042327	biological_process	positive regulation of phosphorylation
L	0042802	molecular_function	identical protein binding
L	0043030	biological_process	regulation of macrophage activation
L	0043066	biological_process	negative regulation of apoptotic process
L	0043518	biological_process	negative regulation of DNA damage response, signal transduction by p53 class mediator
L	0045087	biological_process	innate immune response
L	0048146	biological_process	positive regulation of fibroblast proliferation
L	0050178	molecular_function	phenylpyruvate tautomerase activity
L	0050918	biological_process	positive chemotaxis
L	0051248	biological_process	negative regulation of protein metabolic process
L	0061078	biological_process	obsolete positive regulation of prostaglandin secretion involved in immune response
L	0061081	biological_process	positive regulation of myeloid leukocyte cytokine production involved in immune response
L	0070062	cellular_component	extracellular exosome
L	0070207	biological_process	protein homotrimerization
L	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
L	0080135	biological_process	regulation of cellular response to stress
L	0090238	biological_process	positive regulation of arachidonate secretion
L	0141163	biological_process	positive regulation of cAMP/PKA signal transduction
L	1902166	biological_process	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
L	1904813	cellular_component	ficolin-1-rich granule lumen
L	2000343	biological_process	positive regulation of chemokine (C-X-C motif) ligand 2 production
L	2000773	biological_process	negative regulation of cellular senescence
M	0001516	biological_process	prostaglandin biosynthetic process
M	0001819	biological_process	positive regulation of cytokine production
M	0002020	molecular_function	protease binding
M	0002376	biological_process	immune system process
M	0002906	biological_process	negative regulation of mature B cell apoptotic process
M	0004167	molecular_function	dopachrome isomerase activity
M	0005125	molecular_function	cytokine activity
M	0005126	molecular_function	cytokine receptor binding
M	0005515	molecular_function	protein binding
M	0005576	cellular_component	extracellular region
M	0005615	cellular_component	extracellular space
M	0005737	cellular_component	cytoplasm
M	0005829	cellular_component	cytosol
M	0005886	cellular_component	plasma membrane
M	0006954	biological_process	inflammatory response
M	0007166	biological_process	cell surface receptor signaling pathway
M	0008284	biological_process	positive regulation of cell population proliferation
M	0009986	cellular_component	cell surface
M	0010629	biological_process	negative regulation of gene expression
M	0010760	biological_process	negative regulation of macrophage chemotaxis
M	0016853	molecular_function	isomerase activity
M	0019752	biological_process	carboxylic acid metabolic process
M	0030336	biological_process	negative regulation of cell migration
M	0030890	biological_process	positive regulation of B cell proliferation
M	0031666	biological_process	positive regulation of lipopolysaccharide-mediated signaling pathway
M	0031982	cellular_component	vesicle
M	0032760	biological_process	positive regulation of tumor necrosis factor production
M	0033033	biological_process	negative regulation of myeloid cell apoptotic process
M	0034774	cellular_component	secretory granule lumen
M	0042056	molecular_function	chemoattractant activity
M	0042327	biological_process	positive regulation of phosphorylation
M	0042802	molecular_function	identical protein binding
M	0043030	biological_process	regulation of macrophage activation
M	0043066	biological_process	negative regulation of apoptotic process
M	0043518	biological_process	negative regulation of DNA damage response, signal transduction by p53 class mediator
M	0045087	biological_process	innate immune response
M	0048146	biological_process	positive regulation of fibroblast proliferation
M	0050178	molecular_function	phenylpyruvate tautomerase activity
M	0050918	biological_process	positive chemotaxis
M	0051248	biological_process	negative regulation of protein metabolic process
M	0061078	biological_process	obsolete positive regulation of prostaglandin secretion involved in immune response
M	0061081	biological_process	positive regulation of myeloid leukocyte cytokine production involved in immune response
M	0070062	cellular_component	extracellular exosome
M	0070207	biological_process	protein homotrimerization
M	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
M	0080135	biological_process	regulation of cellular response to stress
M	0090238	biological_process	positive regulation of arachidonate secretion
M	0141163	biological_process	positive regulation of cAMP/PKA signal transduction
M	1902166	biological_process	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
M	1904813	cellular_component	ficolin-1-rich granule lumen
M	2000343	biological_process	positive regulation of chemokine (C-X-C motif) ligand 2 production
M	2000773	biological_process	negative regulation of cellular senescence
N	0001516	biological_process	prostaglandin biosynthetic process
N	0001819	biological_process	positive regulation of cytokine production
N	0002020	molecular_function	protease binding
N	0002376	biological_process	immune system process
N	0002906	biological_process	negative regulation of mature B cell apoptotic process
N	0004167	molecular_function	dopachrome isomerase activity
N	0005125	molecular_function	cytokine activity
N	0005126	molecular_function	cytokine receptor binding
N	0005515	molecular_function	protein binding
N	0005576	cellular_component	extracellular region
N	0005615	cellular_component	extracellular space
N	0005737	cellular_component	cytoplasm
N	0005829	cellular_component	cytosol
N	0005886	cellular_component	plasma membrane
N	0006954	biological_process	inflammatory response
N	0007166	biological_process	cell surface receptor signaling pathway
N	0008284	biological_process	positive regulation of cell population proliferation
N	0009986	cellular_component	cell surface
N	0010629	biological_process	negative regulation of gene expression
N	0010760	biological_process	negative regulation of macrophage chemotaxis
N	0016853	molecular_function	isomerase activity
N	0019752	biological_process	carboxylic acid metabolic process
N	0030336	biological_process	negative regulation of cell migration
N	0030890	biological_process	positive regulation of B cell proliferation
N	0031666	biological_process	positive regulation of lipopolysaccharide-mediated signaling pathway
N	0031982	cellular_component	vesicle
N	0032760	biological_process	positive regulation of tumor necrosis factor production
N	0033033	biological_process	negative regulation of myeloid cell apoptotic process
N	0034774	cellular_component	secretory granule lumen
N	0042056	molecular_function	chemoattractant activity
N	0042327	biological_process	positive regulation of phosphorylation
N	0042802	molecular_function	identical protein binding
N	0043030	biological_process	regulation of macrophage activation
N	0043066	biological_process	negative regulation of apoptotic process
N	0043518	biological_process	negative regulation of DNA damage response, signal transduction by p53 class mediator
N	0045087	biological_process	innate immune response
N	0048146	biological_process	positive regulation of fibroblast proliferation
N	0050178	molecular_function	phenylpyruvate tautomerase activity
N	0050918	biological_process	positive chemotaxis
N	0051248	biological_process	negative regulation of protein metabolic process
N	0061078	biological_process	obsolete positive regulation of prostaglandin secretion involved in immune response
N	0061081	biological_process	positive regulation of myeloid leukocyte cytokine production involved in immune response
N	0070062	cellular_component	extracellular exosome
N	0070207	biological_process	protein homotrimerization
N	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
N	0080135	biological_process	regulation of cellular response to stress
N	0090238	biological_process	positive regulation of arachidonate secretion
N	0141163	biological_process	positive regulation of cAMP/PKA signal transduction
N	1902166	biological_process	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
N	1904813	cellular_component	ficolin-1-rich granule lumen
N	2000343	biological_process	positive regulation of chemokine (C-X-C motif) ligand 2 production
N	2000773	biological_process	negative regulation of cellular senescence
O	0001516	biological_process	prostaglandin biosynthetic process
O	0001819	biological_process	positive regulation of cytokine production
O	0002020	molecular_function	protease binding
O	0002376	biological_process	immune system process
O	0002906	biological_process	negative regulation of mature B cell apoptotic process
O	0004167	molecular_function	dopachrome isomerase activity
O	0005125	molecular_function	cytokine activity
O	0005126	molecular_function	cytokine receptor binding
O	0005515	molecular_function	protein binding
O	0005576	cellular_component	extracellular region
O	0005615	cellular_component	extracellular space
O	0005737	cellular_component	cytoplasm
O	0005829	cellular_component	cytosol
O	0005886	cellular_component	plasma membrane
O	0006954	biological_process	inflammatory response
O	0007166	biological_process	cell surface receptor signaling pathway
O	0008284	biological_process	positive regulation of cell population proliferation
O	0009986	cellular_component	cell surface
O	0010629	biological_process	negative regulation of gene expression
O	0010760	biological_process	negative regulation of macrophage chemotaxis
O	0016853	molecular_function	isomerase activity
O	0019752	biological_process	carboxylic acid metabolic process
O	0030336	biological_process	negative regulation of cell migration
O	0030890	biological_process	positive regulation of B cell proliferation
O	0031666	biological_process	positive regulation of lipopolysaccharide-mediated signaling pathway
O	0031982	cellular_component	vesicle
O	0032760	biological_process	positive regulation of tumor necrosis factor production
O	0033033	biological_process	negative regulation of myeloid cell apoptotic process
O	0034774	cellular_component	secretory granule lumen
O	0042056	molecular_function	chemoattractant activity
O	0042327	biological_process	positive regulation of phosphorylation
O	0042802	molecular_function	identical protein binding
O	0043030	biological_process	regulation of macrophage activation
O	0043066	biological_process	negative regulation of apoptotic process
O	0043518	biological_process	negative regulation of DNA damage response, signal transduction by p53 class mediator
O	0045087	biological_process	innate immune response
O	0048146	biological_process	positive regulation of fibroblast proliferation
O	0050178	molecular_function	phenylpyruvate tautomerase activity
O	0050918	biological_process	positive chemotaxis
O	0051248	biological_process	negative regulation of protein metabolic process
O	0061078	biological_process	obsolete positive regulation of prostaglandin secretion involved in immune response
O	0061081	biological_process	positive regulation of myeloid leukocyte cytokine production involved in immune response
O	0070062	cellular_component	extracellular exosome
O	0070207	biological_process	protein homotrimerization
O	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
O	0080135	biological_process	regulation of cellular response to stress
O	0090238	biological_process	positive regulation of arachidonate secretion
O	0141163	biological_process	positive regulation of cAMP/PKA signal transduction
O	1902166	biological_process	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
O	1904813	cellular_component	ficolin-1-rich granule lumen
O	2000343	biological_process	positive regulation of chemokine (C-X-C motif) ligand 2 production
O	2000773	biological_process	negative regulation of cellular senescence
P	0001516	biological_process	prostaglandin biosynthetic process
P	0001819	biological_process	positive regulation of cytokine production
P	0002020	molecular_function	protease binding
P	0002376	biological_process	immune system process
P	0002906	biological_process	negative regulation of mature B cell apoptotic process
P	0004167	molecular_function	dopachrome isomerase activity
P	0005125	molecular_function	cytokine activity
P	0005126	molecular_function	cytokine receptor binding
P	0005515	molecular_function	protein binding
P	0005576	cellular_component	extracellular region
P	0005615	cellular_component	extracellular space
P	0005737	cellular_component	cytoplasm
P	0005829	cellular_component	cytosol
P	0005886	cellular_component	plasma membrane
P	0006954	biological_process	inflammatory response
P	0007166	biological_process	cell surface receptor signaling pathway
P	0008284	biological_process	positive regulation of cell population proliferation
P	0009986	cellular_component	cell surface
P	0010629	biological_process	negative regulation of gene expression
P	0010760	biological_process	negative regulation of macrophage chemotaxis
P	0016853	molecular_function	isomerase activity
P	0019752	biological_process	carboxylic acid metabolic process
P	0030336	biological_process	negative regulation of cell migration
P	0030890	biological_process	positive regulation of B cell proliferation
P	0031666	biological_process	positive regulation of lipopolysaccharide-mediated signaling pathway
P	0031982	cellular_component	vesicle
P	0032760	biological_process	positive regulation of tumor necrosis factor production
P	0033033	biological_process	negative regulation of myeloid cell apoptotic process
P	0034774	cellular_component	secretory granule lumen
P	0042056	molecular_function	chemoattractant activity
P	0042327	biological_process	positive regulation of phosphorylation
P	0042802	molecular_function	identical protein binding
P	0043030	biological_process	regulation of macrophage activation
P	0043066	biological_process	negative regulation of apoptotic process
P	0043518	biological_process	negative regulation of DNA damage response, signal transduction by p53 class mediator
P	0045087	biological_process	innate immune response
P	0048146	biological_process	positive regulation of fibroblast proliferation
P	0050178	molecular_function	phenylpyruvate tautomerase activity
P	0050918	biological_process	positive chemotaxis
P	0051248	biological_process	negative regulation of protein metabolic process
P	0061078	biological_process	obsolete positive regulation of prostaglandin secretion involved in immune response
P	0061081	biological_process	positive regulation of myeloid leukocyte cytokine production involved in immune response
P	0070062	cellular_component	extracellular exosome
P	0070207	biological_process	protein homotrimerization
P	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
P	0080135	biological_process	regulation of cellular response to stress
P	0090238	biological_process	positive regulation of arachidonate secretion
P	0141163	biological_process	positive regulation of cAMP/PKA signal transduction
P	1902166	biological_process	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
P	1904813	cellular_component	ficolin-1-rich granule lumen
P	2000343	biological_process	positive regulation of chemokine (C-X-C motif) ligand 2 production
P	2000773	biological_process	negative regulation of cellular senescence
Q	0001516	biological_process	prostaglandin biosynthetic process
Q	0001819	biological_process	positive regulation of cytokine production
Q	0002020	molecular_function	protease binding
Q	0002376	biological_process	immune system process
Q	0002906	biological_process	negative regulation of mature B cell apoptotic process
Q	0004167	molecular_function	dopachrome isomerase activity
Q	0005125	molecular_function	cytokine activity
Q	0005126	molecular_function	cytokine receptor binding
Q	0005515	molecular_function	protein binding
Q	0005576	cellular_component	extracellular region
Q	0005615	cellular_component	extracellular space
Q	0005737	cellular_component	cytoplasm
Q	0005829	cellular_component	cytosol
Q	0005886	cellular_component	plasma membrane
Q	0006954	biological_process	inflammatory response
Q	0007166	biological_process	cell surface receptor signaling pathway
Q	0008284	biological_process	positive regulation of cell population proliferation
Q	0009986	cellular_component	cell surface
Q	0010629	biological_process	negative regulation of gene expression
Q	0010760	biological_process	negative regulation of macrophage chemotaxis
Q	0016853	molecular_function	isomerase activity
Q	0019752	biological_process	carboxylic acid metabolic process
Q	0030336	biological_process	negative regulation of cell migration
Q	0030890	biological_process	positive regulation of B cell proliferation
Q	0031666	biological_process	positive regulation of lipopolysaccharide-mediated signaling pathway
Q	0031982	cellular_component	vesicle
Q	0032760	biological_process	positive regulation of tumor necrosis factor production
Q	0033033	biological_process	negative regulation of myeloid cell apoptotic process
Q	0034774	cellular_component	secretory granule lumen
Q	0042056	molecular_function	chemoattractant activity
Q	0042327	biological_process	positive regulation of phosphorylation
Q	0042802	molecular_function	identical protein binding
Q	0043030	biological_process	regulation of macrophage activation
Q	0043066	biological_process	negative regulation of apoptotic process
Q	0043518	biological_process	negative regulation of DNA damage response, signal transduction by p53 class mediator
Q	0045087	biological_process	innate immune response
Q	0048146	biological_process	positive regulation of fibroblast proliferation
Q	0050178	molecular_function	phenylpyruvate tautomerase activity
Q	0050918	biological_process	positive chemotaxis
Q	0051248	biological_process	negative regulation of protein metabolic process
Q	0061078	biological_process	obsolete positive regulation of prostaglandin secretion involved in immune response
Q	0061081	biological_process	positive regulation of myeloid leukocyte cytokine production involved in immune response
Q	0070062	cellular_component	extracellular exosome
Q	0070207	biological_process	protein homotrimerization
Q	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
Q	0080135	biological_process	regulation of cellular response to stress
Q	0090238	biological_process	positive regulation of arachidonate secretion
Q	0141163	biological_process	positive regulation of cAMP/PKA signal transduction
Q	1902166	biological_process	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
Q	1904813	cellular_component	ficolin-1-rich granule lumen
Q	2000343	biological_process	positive regulation of chemokine (C-X-C motif) ligand 2 production
Q	2000773	biological_process	negative regulation of cellular senescence
R	0001516	biological_process	prostaglandin biosynthetic process
R	0001819	biological_process	positive regulation of cytokine production
R	0002020	molecular_function	protease binding
R	0002376	biological_process	immune system process
R	0002906	biological_process	negative regulation of mature B cell apoptotic process
R	0004167	molecular_function	dopachrome isomerase activity
R	0005125	molecular_function	cytokine activity
R	0005126	molecular_function	cytokine receptor binding
R	0005515	molecular_function	protein binding
R	0005576	cellular_component	extracellular region
R	0005615	cellular_component	extracellular space
R	0005737	cellular_component	cytoplasm
R	0005829	cellular_component	cytosol
R	0005886	cellular_component	plasma membrane
R	0006954	biological_process	inflammatory response
R	0007166	biological_process	cell surface receptor signaling pathway
R	0008284	biological_process	positive regulation of cell population proliferation
R	0009986	cellular_component	cell surface
R	0010629	biological_process	negative regulation of gene expression
R	0010760	biological_process	negative regulation of macrophage chemotaxis
R	0016853	molecular_function	isomerase activity
R	0019752	biological_process	carboxylic acid metabolic process
R	0030336	biological_process	negative regulation of cell migration
R	0030890	biological_process	positive regulation of B cell proliferation
R	0031666	biological_process	positive regulation of lipopolysaccharide-mediated signaling pathway
R	0031982	cellular_component	vesicle
R	0032760	biological_process	positive regulation of tumor necrosis factor production
R	0033033	biological_process	negative regulation of myeloid cell apoptotic process
R	0034774	cellular_component	secretory granule lumen
R	0042056	molecular_function	chemoattractant activity
R	0042327	biological_process	positive regulation of phosphorylation
R	0042802	molecular_function	identical protein binding
R	0043030	biological_process	regulation of macrophage activation
R	0043066	biological_process	negative regulation of apoptotic process
R	0043518	biological_process	negative regulation of DNA damage response, signal transduction by p53 class mediator
R	0045087	biological_process	innate immune response
R	0048146	biological_process	positive regulation of fibroblast proliferation
R	0050178	molecular_function	phenylpyruvate tautomerase activity
R	0050918	biological_process	positive chemotaxis
R	0051248	biological_process	negative regulation of protein metabolic process
R	0061078	biological_process	obsolete positive regulation of prostaglandin secretion involved in immune response
R	0061081	biological_process	positive regulation of myeloid leukocyte cytokine production involved in immune response
R	0070062	cellular_component	extracellular exosome
R	0070207	biological_process	protein homotrimerization
R	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
R	0080135	biological_process	regulation of cellular response to stress
R	0090238	biological_process	positive regulation of arachidonate secretion
R	0141163	biological_process	positive regulation of cAMP/PKA signal transduction
R	1902166	biological_process	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
R	1904813	cellular_component	ficolin-1-rich granule lumen
R	2000343	biological_process	positive regulation of chemokine (C-X-C motif) ligand 2 production
R	2000773	biological_process	negative regulation of cellular senescence

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue SO4 A 201

Chain	Residue
A	GLY68
A	GLY69
A	ALA70
A	GLN71

---

site_id	AC2
Number of Residues	3
Details	binding site for residue SO4 A 202

Chain	Residue
A	MET101
A	ASN102
A	ALA103

---

site_id	AC3
Number of Residues	5
Details	binding site for residue SO4 A 203

Chain	Residue
A	PHE18
A	LEU19
A	SER20
A	ASP16
A	GLY17

---

site_id	AC4
Number of Residues	4
Details	binding site for residue SO4 B 201

Chain	Residue
B	GLY68
B	GLY69
B	ALA70
B	GLN71

---

site_id	AC5
Number of Residues	4
Details	binding site for residue SO4 B 202

Chain	Residue
B	GLY65
B	LYS66
B	ILE67
B	GLN71

---

site_id	AC6
Number of Residues	5
Details	binding site for residue SO4 B 203

Chain	Residue
B	ASP16
B	GLY17
B	PHE18
B	LEU19
B	SER20

---

site_id	AC7
Number of Residues	14
Details	binding site for residue 3TX C 201

Chain	Residue
B	TYR95
B	ASN97
C	PRO1
C	MET2
C	LYS32
C	PRO33
C	TYR36
C	HIS62
C	SER63
C	ILE64
C	VAL106
C	PHE113
F	PHE113
F	3TX201

---

site_id	AC8
Number of Residues	4
Details	binding site for residue SO4 C 202

Chain	Residue
C	GLY68
C	GLY69
C	ALA70
C	GLN71

---

site_id	AC9
Number of Residues	5
Details	binding site for residue SO4 C 203

Chain	Residue
B	LYS66
C	GLY69
C	ALA70
C	ARG73
C	HOH301

---

site_id	AD1
Number of Residues	5
Details	binding site for residue SO4 C 204

Chain	Residue
C	ASP16
C	GLY17
C	PHE18
C	LEU19
C	SER20

---

site_id	AD2
Number of Residues	4
Details	binding site for residue SO4 D 201

Chain	Residue
D	GLY68
D	GLY69
D	ALA70
D	GLN71

---

site_id	AD3
Number of Residues	2
Details	binding site for residue SO4 D 202

Chain	Residue
D	ASN102
D	ALA103

---

site_id	AD4
Number of Residues	5
Details	binding site for residue SO4 D 203

Chain	Residue
D	ASP16
D	GLY17
D	PHE18
D	LEU19
D	SER20

---

site_id	AD5
Number of Residues	4
Details	binding site for residue SO4 E 201

Chain	Residue
E	GLY68
E	GLY69
E	ALA70
E	GLN71

---

site_id	AD6
Number of Residues	4
Details	binding site for residue SO4 E 202

Chain	Residue
E	GLY65
E	LYS66
E	ILE67
E	GLN71

---

site_id	AD7
Number of Residues	4
Details	binding site for residue SO4 E 203

Chain	Residue
E	GLY17
E	PHE18
E	LEU19
E	SER20

---

site_id	AD8
Number of Residues	13
Details	binding site for residue 3TX F 201

Chain	Residue
C	PHE113
C	3TX201
E	TYR95
E	ASN97
F	PRO1
F	MET2
F	LYS32
F	PRO33
F	TYR36
F	SER63
F	ILE64
F	VAL106
F	PHE113

---

site_id	AD9
Number of Residues	4
Details	binding site for residue SO4 F 202

Chain	Residue
F	GLY68
F	GLY69
F	ALA70
F	GLN71

---

site_id	AE1
Number of Residues	4
Details	binding site for residue SO4 F 203

Chain	Residue
E	LYS66
F	GLY69
F	ARG73
F	HOH301

---

site_id	AE2
Number of Residues	5
Details	binding site for residue SO4 F 204

Chain	Residue
F	PHE18
F	LEU19
F	SER20
F	ASP16
F	GLY17

---

site_id	AE3
Number of Residues	5
Details	binding site for residue SO4 G 201

Chain	Residue
G	GLY68
G	GLY69
G	ALA70
G	GLN71
G	HOH315

---

site_id	AE4
Number of Residues	6
Details	binding site for residue SO4 G 202

Chain	Residue
G	PRO15
G	ASP16
G	GLY17
G	PHE18
G	LEU19
G	SER20

---

site_id	AE5
Number of Residues	2
Details	binding site for residue SO4 G 203

Chain	Residue
G	ASN102
G	ALA103

---

site_id	AE6
Number of Residues	4
Details	binding site for residue SO4 H 201

Chain	Residue
H	GLY68
H	GLY69
H	ALA70
H	GLN71

---

site_id	AE7
Number of Residues	3
Details	binding site for residue SO4 H 202

Chain	Residue
H	LYS66
H	ILE67
H	GLN71

---

site_id	AE8
Number of Residues	5
Details	binding site for residue SO4 H 203

Chain	Residue
H	ASP16
H	GLY17
H	PHE18
H	LEU19
H	SER20

---

site_id	AE9
Number of Residues	13
Details	binding site for residue 3TX I 201

Chain	Residue
H	TYR95
H	ASN97
I	PRO1
I	MET2
I	LYS32
I	PRO33
I	TYR36
I	HIS62
I	ILE64
I	VAL106
I	PHE113
R	PHE113
R	3TX201

---

site_id	AF1
Number of Residues	4
Details	binding site for residue SO4 I 202

Chain	Residue
I	GLY68
I	GLY69
I	ALA70
I	GLN71

---

site_id	AF2
Number of Residues	5
Details	binding site for residue SO4 I 203

Chain	Residue
H	LYS66
I	GLY69
I	ALA70
I	ARG73
I	HOH301

---

site_id	AF3
Number of Residues	4
Details	binding site for residue SO4 I 204

Chain	Residue
I	GLY17
I	PHE18
I	LEU19
I	SER20

---

site_id	AF4
Number of Residues	4
Details	binding site for residue SO4 J 201

Chain	Residue
J	GLY68
J	GLY69
J	ALA70
J	GLN71

---

site_id	AF5
Number of Residues	5
Details	binding site for residue SO4 J 202

Chain	Residue
J	ASP16
J	GLY17
J	PHE18
J	LEU19
J	SER20

---

site_id	AF6
Number of Residues	2
Details	binding site for residue SO4 J 203

Chain	Residue
D	ARG88
J	ARG88

---

site_id	AF7
Number of Residues	3
Details	binding site for residue SO4 K 201

Chain	Residue
K	GLY68
K	ALA70
K	GLN71

---

site_id	AF8
Number of Residues	3
Details	binding site for residue SO4 K 202

Chain	Residue
K	LYS66
K	ILE67
K	GLN71

---

site_id	AF9
Number of Residues	5
Details	binding site for residue SO4 K 203

Chain	Residue
K	ASP16
K	GLY17
K	PHE18
K	LEU19
K	SER20

---

site_id	AG1
Number of Residues	13
Details	binding site for residue 3TX L 201

Chain	Residue
K	TYR95
K	ASN97
L	PRO1
L	MET2
L	LYS32
L	PRO33
L	TYR36
L	HIS62
L	ILE64
L	VAL106
L	PHE113
O	PHE113
O	3TX201

---

site_id	AG2
Number of Residues	4
Details	binding site for residue SO4 L 202

Chain	Residue
L	GLY68
L	GLY69
L	ALA70
L	GLN71

---

site_id	AG3
Number of Residues	4
Details	binding site for residue SO4 L 203

Chain	Residue
K	LYS66
L	GLY69
L	ALA70
L	ARG73

---

site_id	AG4
Number of Residues	5
Details	binding site for residue SO4 L 204

Chain	Residue
L	ASP16
L	GLY17
L	PHE18
L	LEU19
L	SER20

---

site_id	AG5
Number of Residues	4
Details	binding site for residue SO4 M 201

Chain	Residue
M	GLY68
M	GLY69
M	ALA70
M	GLN71

---

site_id	AG6
Number of Residues	6
Details	binding site for residue SO4 M 202

Chain	Residue
M	PRO15
M	ASP16
M	GLY17
M	PHE18
M	LEU19
M	SER20

---

site_id	AG7
Number of Residues	5
Details	binding site for residue SO4 N 201

Chain	Residue
N	GLY68
N	GLY69
N	ALA70
N	GLN71
N	HOH301

---

site_id	AG8
Number of Residues	3
Details	binding site for residue SO4 N 202

Chain	Residue
N	LYS66
N	ILE67
N	GLN71

---

site_id	AG9
Number of Residues	4
Details	binding site for residue SO4 N 203

Chain	Residue
N	GLY17
N	PHE18
N	LEU19
N	SER20

---

site_id	AH1
Number of Residues	13
Details	binding site for residue 3TX O 201

Chain	Residue
L	PHE113
L	3TX201
N	TYR95
N	ASN97
O	PRO1
O	MET2
O	LYS32
O	PRO33
O	TYR36
O	HIS62
O	SER63
O	ILE64
O	PHE113

---

site_id	AH2
Number of Residues	5
Details	binding site for residue SO4 O 202

Chain	Residue
K	ARG73
O	GLY68
O	GLY69
O	ALA70
O	GLN71

---

site_id	AH3
Number of Residues	4
Details	binding site for residue SO4 O 203

Chain	Residue
N	LYS66
O	GLY69
O	ARG73
O	HOH301

---

site_id	AH4
Number of Residues	4
Details	binding site for residue SO4 O 204

Chain	Residue
O	GLY17
O	PHE18
O	LEU19
O	SER20

---

site_id	AH5
Number of Residues	4
Details	binding site for residue SO4 P 201

Chain	Residue
P	GLY68
P	GLY69
P	ALA70
P	GLN71

---

site_id	AH6
Number of Residues	2
Details	binding site for residue SO4 P 202

Chain	Residue
P	ASN102
P	ALA103

---

site_id	AH7
Number of Residues	6
Details	binding site for residue SO4 P 203

Chain	Residue
P	PRO15
P	ASP16
P	GLY17
P	PHE18
P	LEU19
P	SER20

---

site_id	AH8
Number of Residues	4
Details	binding site for residue SO4 Q 201

Chain	Residue
Q	GLY68
Q	GLY69
Q	ALA70
Q	GLN71

---

site_id	AH9
Number of Residues	4
Details	binding site for residue SO4 Q 202

Chain	Residue
Q	GLY65
Q	LYS66
Q	ILE67
Q	GLN71

---

site_id	AI1
Number of Residues	5
Details	binding site for residue SO4 Q 203

Chain	Residue
Q	ASP16
Q	GLY17
Q	PHE18
Q	LEU19
Q	SER20

---

site_id	AI2
Number of Residues	15
Details	binding site for residue 3TX R 201

Chain	Residue
I	TRP108
I	PHE113
I	3TX201
Q	TYR95
Q	ASN97
R	PRO1
R	MET2
R	LYS32
R	PRO33
R	TYR36
R	HIS62
R	SER63
R	ILE64
R	VAL106
R	PHE113

---

site_id	AI3
Number of Residues	6
Details	binding site for residue SO4 R 202

Chain	Residue
R	GLY68
R	GLY69
R	ALA70
R	GLN71
R	SO4203
R	HOH312

---

site_id	AI4
Number of Residues	5
Details	binding site for residue SO4 R 203

Chain	Residue
Q	LYS66
R	GLY69
R	ALA70
R	ARG73
R	SO4202

---

site_id	AI5
Number of Residues	5
Details	binding site for residue SO4 R 204

Chain	Residue
R	ASP16
R	GLY17
R	PHE18
R	LEU19
R	SER20

---

Functional Information from PROSITE/UniProt

site_id	PS01158
Number of Residues	15
Details	MIF Macrophage migration inhibitory factor family signature. EPCAlcsLhSIGkIG

Chain	Residue	Details
A	GLU54-GLY68

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	18
Details	Active site: {"description":"Proton acceptor; via imino nitrogen","evidences":[{"source":"UniProtKB","id":"P34884","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	54
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11170644","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17526494","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19090677","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	18
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P34884","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---