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4WR8

Macrophage Migration Inhibitory Factor in complex with a biaryltriazole inhibitor (3b-180)

Functional Information from GO Data
ChainGOidnamespacecontents
A0001516biological_processprostaglandin biosynthetic process
A0001819biological_processpositive regulation of cytokine production
A0001934biological_processpositive regulation of protein phosphorylation
A0002020molecular_functionprotease binding
A0002906biological_processnegative regulation of mature B cell apoptotic process
A0004167molecular_functiondopachrome isomerase activity
A0005125molecular_functioncytokine activity
A0005126molecular_functioncytokine receptor binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006954biological_processinflammatory response
A0007166biological_processcell surface receptor signaling pathway
A0008284biological_processpositive regulation of cell population proliferation
A0009986cellular_componentcell surface
A0010629biological_processnegative regulation of gene expression
A0010739biological_processpositive regulation of protein kinase A signaling
A0010760biological_processnegative regulation of macrophage chemotaxis
A0016853molecular_functionisomerase activity
A0019752biological_processcarboxylic acid metabolic process
A0030330biological_processDNA damage response, signal transduction by p53 class mediator
A0030336biological_processnegative regulation of cell migration
A0030890biological_processpositive regulation of B cell proliferation
A0031666biological_processpositive regulation of lipopolysaccharide-mediated signaling pathway
A0031982cellular_componentvesicle
A0032760biological_processpositive regulation of tumor necrosis factor production
A0033033biological_processnegative regulation of myeloid cell apoptotic process
A0033138biological_processpositive regulation of peptidyl-serine phosphorylation
A0034774cellular_componentsecretory granule lumen
A0042056molecular_functionchemoattractant activity
A0042127biological_processregulation of cell population proliferation
A0042327biological_processpositive regulation of phosphorylation
A0042802molecular_functionidentical protein binding
A0043030biological_processregulation of macrophage activation
A0043066biological_processnegative regulation of apoptotic process
A0043518biological_processnegative regulation of DNA damage response, signal transduction by p53 class mediator
A0045087biological_processinnate immune response
A0048146biological_processpositive regulation of fibroblast proliferation
A0050178molecular_functionphenylpyruvate tautomerase activity
A0050731biological_processpositive regulation of peptidyl-tyrosine phosphorylation
A0050918biological_processpositive chemotaxis
A0051248biological_processnegative regulation of protein metabolic process
A0061078biological_processpositive regulation of prostaglandin secretion involved in immune response
A0061081biological_processpositive regulation of myeloid leukocyte cytokine production involved in immune response
A0070062cellular_componentextracellular exosome
A0070207biological_processprotein homotrimerization
A0070374biological_processpositive regulation of ERK1 and ERK2 cascade
A0090238biological_processpositive regulation of arachidonic acid secretion
A0090398biological_processcellular senescence
A1902166biological_processnegative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
A1904813cellular_componentficolin-1-rich granule lumen
A2000343biological_processpositive regulation of chemokine (C-X-C motif) ligand 2 production
A2000773biological_processnegative regulation of cellular senescence
B0001516biological_processprostaglandin biosynthetic process
B0001819biological_processpositive regulation of cytokine production
B0001934biological_processpositive regulation of protein phosphorylation
B0002020molecular_functionprotease binding
B0002906biological_processnegative regulation of mature B cell apoptotic process
B0004167molecular_functiondopachrome isomerase activity
B0005125molecular_functioncytokine activity
B0005126molecular_functioncytokine receptor binding
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0006954biological_processinflammatory response
B0007166biological_processcell surface receptor signaling pathway
B0008284biological_processpositive regulation of cell population proliferation
B0009986cellular_componentcell surface
B0010629biological_processnegative regulation of gene expression
B0010739biological_processpositive regulation of protein kinase A signaling
B0010760biological_processnegative regulation of macrophage chemotaxis
B0016853molecular_functionisomerase activity
B0019752biological_processcarboxylic acid metabolic process
B0030330biological_processDNA damage response, signal transduction by p53 class mediator
B0030336biological_processnegative regulation of cell migration
B0030890biological_processpositive regulation of B cell proliferation
B0031666biological_processpositive regulation of lipopolysaccharide-mediated signaling pathway
B0031982cellular_componentvesicle
B0032760biological_processpositive regulation of tumor necrosis factor production
B0033033biological_processnegative regulation of myeloid cell apoptotic process
B0033138biological_processpositive regulation of peptidyl-serine phosphorylation
B0034774cellular_componentsecretory granule lumen
B0042056molecular_functionchemoattractant activity
B0042127biological_processregulation of cell population proliferation
B0042327biological_processpositive regulation of phosphorylation
B0042802molecular_functionidentical protein binding
B0043030biological_processregulation of macrophage activation
B0043066biological_processnegative regulation of apoptotic process
B0043518biological_processnegative regulation of DNA damage response, signal transduction by p53 class mediator
B0045087biological_processinnate immune response
B0048146biological_processpositive regulation of fibroblast proliferation
B0050178molecular_functionphenylpyruvate tautomerase activity
B0050731biological_processpositive regulation of peptidyl-tyrosine phosphorylation
B0050918biological_processpositive chemotaxis
B0051248biological_processnegative regulation of protein metabolic process
B0061078biological_processpositive regulation of prostaglandin secretion involved in immune response
B0061081biological_processpositive regulation of myeloid leukocyte cytokine production involved in immune response
B0070062cellular_componentextracellular exosome
B0070207biological_processprotein homotrimerization
B0070374biological_processpositive regulation of ERK1 and ERK2 cascade
B0090238biological_processpositive regulation of arachidonic acid secretion
B0090398biological_processcellular senescence
B1902166biological_processnegative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
B1904813cellular_componentficolin-1-rich granule lumen
B2000343biological_processpositive regulation of chemokine (C-X-C motif) ligand 2 production
B2000773biological_processnegative regulation of cellular senescence
C0001516biological_processprostaglandin biosynthetic process
C0001819biological_processpositive regulation of cytokine production
C0001934biological_processpositive regulation of protein phosphorylation
C0002020molecular_functionprotease binding
C0002906biological_processnegative regulation of mature B cell apoptotic process
C0004167molecular_functiondopachrome isomerase activity
C0005125molecular_functioncytokine activity
C0005126molecular_functioncytokine receptor binding
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0006954biological_processinflammatory response
C0007166biological_processcell surface receptor signaling pathway
C0008284biological_processpositive regulation of cell population proliferation
C0009986cellular_componentcell surface
C0010629biological_processnegative regulation of gene expression
C0010739biological_processpositive regulation of protein kinase A signaling
C0010760biological_processnegative regulation of macrophage chemotaxis
C0016853molecular_functionisomerase activity
C0019752biological_processcarboxylic acid metabolic process
C0030330biological_processDNA damage response, signal transduction by p53 class mediator
C0030336biological_processnegative regulation of cell migration
C0030890biological_processpositive regulation of B cell proliferation
C0031666biological_processpositive regulation of lipopolysaccharide-mediated signaling pathway
C0031982cellular_componentvesicle
C0032760biological_processpositive regulation of tumor necrosis factor production
C0033033biological_processnegative regulation of myeloid cell apoptotic process
C0033138biological_processpositive regulation of peptidyl-serine phosphorylation
C0034774cellular_componentsecretory granule lumen
C0042056molecular_functionchemoattractant activity
C0042127biological_processregulation of cell population proliferation
C0042327biological_processpositive regulation of phosphorylation
C0042802molecular_functionidentical protein binding
C0043030biological_processregulation of macrophage activation
C0043066biological_processnegative regulation of apoptotic process
C0043518biological_processnegative regulation of DNA damage response, signal transduction by p53 class mediator
C0045087biological_processinnate immune response
C0048146biological_processpositive regulation of fibroblast proliferation
C0050178molecular_functionphenylpyruvate tautomerase activity
C0050731biological_processpositive regulation of peptidyl-tyrosine phosphorylation
C0050918biological_processpositive chemotaxis
C0051248biological_processnegative regulation of protein metabolic process
C0061078biological_processpositive regulation of prostaglandin secretion involved in immune response
C0061081biological_processpositive regulation of myeloid leukocyte cytokine production involved in immune response
C0070062cellular_componentextracellular exosome
C0070207biological_processprotein homotrimerization
C0070374biological_processpositive regulation of ERK1 and ERK2 cascade
C0090238biological_processpositive regulation of arachidonic acid secretion
C0090398biological_processcellular senescence
C1902166biological_processnegative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
C1904813cellular_componentficolin-1-rich granule lumen
C2000343biological_processpositive regulation of chemokine (C-X-C motif) ligand 2 production
C2000773biological_processnegative regulation of cellular senescence
D0001516biological_processprostaglandin biosynthetic process
D0001819biological_processpositive regulation of cytokine production
D0001934biological_processpositive regulation of protein phosphorylation
D0002020molecular_functionprotease binding
D0002906biological_processnegative regulation of mature B cell apoptotic process
D0004167molecular_functiondopachrome isomerase activity
D0005125molecular_functioncytokine activity
D0005126molecular_functioncytokine receptor binding
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0005886cellular_componentplasma membrane
D0006954biological_processinflammatory response
D0007166biological_processcell surface receptor signaling pathway
D0008284biological_processpositive regulation of cell population proliferation
D0009986cellular_componentcell surface
D0010629biological_processnegative regulation of gene expression
D0010739biological_processpositive regulation of protein kinase A signaling
D0010760biological_processnegative regulation of macrophage chemotaxis
D0016853molecular_functionisomerase activity
D0019752biological_processcarboxylic acid metabolic process
D0030330biological_processDNA damage response, signal transduction by p53 class mediator
D0030336biological_processnegative regulation of cell migration
D0030890biological_processpositive regulation of B cell proliferation
D0031666biological_processpositive regulation of lipopolysaccharide-mediated signaling pathway
D0031982cellular_componentvesicle
D0032760biological_processpositive regulation of tumor necrosis factor production
D0033033biological_processnegative regulation of myeloid cell apoptotic process
D0033138biological_processpositive regulation of peptidyl-serine phosphorylation
D0034774cellular_componentsecretory granule lumen
D0042056molecular_functionchemoattractant activity
D0042127biological_processregulation of cell population proliferation
D0042327biological_processpositive regulation of phosphorylation
D0042802molecular_functionidentical protein binding
D0043030biological_processregulation of macrophage activation
D0043066biological_processnegative regulation of apoptotic process
D0043518biological_processnegative regulation of DNA damage response, signal transduction by p53 class mediator
D0045087biological_processinnate immune response
D0048146biological_processpositive regulation of fibroblast proliferation
D0050178molecular_functionphenylpyruvate tautomerase activity
D0050731biological_processpositive regulation of peptidyl-tyrosine phosphorylation
D0050918biological_processpositive chemotaxis
D0051248biological_processnegative regulation of protein metabolic process
D0061078biological_processpositive regulation of prostaglandin secretion involved in immune response
D0061081biological_processpositive regulation of myeloid leukocyte cytokine production involved in immune response
D0070062cellular_componentextracellular exosome
D0070207biological_processprotein homotrimerization
D0070374biological_processpositive regulation of ERK1 and ERK2 cascade
D0090238biological_processpositive regulation of arachidonic acid secretion
D0090398biological_processcellular senescence
D1902166biological_processnegative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
D1904813cellular_componentficolin-1-rich granule lumen
D2000343biological_processpositive regulation of chemokine (C-X-C motif) ligand 2 production
D2000773biological_processnegative regulation of cellular senescence
E0001516biological_processprostaglandin biosynthetic process
E0001819biological_processpositive regulation of cytokine production
E0001934biological_processpositive regulation of protein phosphorylation
E0002020molecular_functionprotease binding
E0002906biological_processnegative regulation of mature B cell apoptotic process
E0004167molecular_functiondopachrome isomerase activity
E0005125molecular_functioncytokine activity
E0005126molecular_functioncytokine receptor binding
E0005515molecular_functionprotein binding
E0005576cellular_componentextracellular region
E0005615cellular_componentextracellular space
E0005654cellular_componentnucleoplasm
E0005737cellular_componentcytoplasm
E0005829cellular_componentcytosol
E0005886cellular_componentplasma membrane
E0006954biological_processinflammatory response
E0007166biological_processcell surface receptor signaling pathway
E0008284biological_processpositive regulation of cell population proliferation
E0009986cellular_componentcell surface
E0010629biological_processnegative regulation of gene expression
E0010739biological_processpositive regulation of protein kinase A signaling
E0010760biological_processnegative regulation of macrophage chemotaxis
E0016853molecular_functionisomerase activity
E0019752biological_processcarboxylic acid metabolic process
E0030330biological_processDNA damage response, signal transduction by p53 class mediator
E0030336biological_processnegative regulation of cell migration
E0030890biological_processpositive regulation of B cell proliferation
E0031666biological_processpositive regulation of lipopolysaccharide-mediated signaling pathway
E0031982cellular_componentvesicle
E0032760biological_processpositive regulation of tumor necrosis factor production
E0033033biological_processnegative regulation of myeloid cell apoptotic process
E0033138biological_processpositive regulation of peptidyl-serine phosphorylation
E0034774cellular_componentsecretory granule lumen
E0042056molecular_functionchemoattractant activity
E0042127biological_processregulation of cell population proliferation
E0042327biological_processpositive regulation of phosphorylation
E0042802molecular_functionidentical protein binding
E0043030biological_processregulation of macrophage activation
E0043066biological_processnegative regulation of apoptotic process
E0043518biological_processnegative regulation of DNA damage response, signal transduction by p53 class mediator
E0045087biological_processinnate immune response
E0048146biological_processpositive regulation of fibroblast proliferation
E0050178molecular_functionphenylpyruvate tautomerase activity
E0050731biological_processpositive regulation of peptidyl-tyrosine phosphorylation
E0050918biological_processpositive chemotaxis
E0051248biological_processnegative regulation of protein metabolic process
E0061078biological_processpositive regulation of prostaglandin secretion involved in immune response
E0061081biological_processpositive regulation of myeloid leukocyte cytokine production involved in immune response
E0070062cellular_componentextracellular exosome
E0070207biological_processprotein homotrimerization
E0070374biological_processpositive regulation of ERK1 and ERK2 cascade
E0090238biological_processpositive regulation of arachidonic acid secretion
E0090398biological_processcellular senescence
E1902166biological_processnegative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
E1904813cellular_componentficolin-1-rich granule lumen
E2000343biological_processpositive regulation of chemokine (C-X-C motif) ligand 2 production
E2000773biological_processnegative regulation of cellular senescence
F0001516biological_processprostaglandin biosynthetic process
F0001819biological_processpositive regulation of cytokine production
F0001934biological_processpositive regulation of protein phosphorylation
F0002020molecular_functionprotease binding
F0002906biological_processnegative regulation of mature B cell apoptotic process
F0004167molecular_functiondopachrome isomerase activity
F0005125molecular_functioncytokine activity
F0005126molecular_functioncytokine receptor binding
F0005515molecular_functionprotein binding
F0005576cellular_componentextracellular region
F0005615cellular_componentextracellular space
F0005654cellular_componentnucleoplasm
F0005737cellular_componentcytoplasm
F0005829cellular_componentcytosol
F0005886cellular_componentplasma membrane
F0006954biological_processinflammatory response
F0007166biological_processcell surface receptor signaling pathway
F0008284biological_processpositive regulation of cell population proliferation
F0009986cellular_componentcell surface
F0010629biological_processnegative regulation of gene expression
F0010739biological_processpositive regulation of protein kinase A signaling
F0010760biological_processnegative regulation of macrophage chemotaxis
F0016853molecular_functionisomerase activity
F0019752biological_processcarboxylic acid metabolic process
F0030330biological_processDNA damage response, signal transduction by p53 class mediator
F0030336biological_processnegative regulation of cell migration
F0030890biological_processpositive regulation of B cell proliferation
F0031666biological_processpositive regulation of lipopolysaccharide-mediated signaling pathway
F0031982cellular_componentvesicle
F0032760biological_processpositive regulation of tumor necrosis factor production
F0033033biological_processnegative regulation of myeloid cell apoptotic process
F0033138biological_processpositive regulation of peptidyl-serine phosphorylation
F0034774cellular_componentsecretory granule lumen
F0042056molecular_functionchemoattractant activity
F0042127biological_processregulation of cell population proliferation
F0042327biological_processpositive regulation of phosphorylation
F0042802molecular_functionidentical protein binding
F0043030biological_processregulation of macrophage activation
F0043066biological_processnegative regulation of apoptotic process
F0043518biological_processnegative regulation of DNA damage response, signal transduction by p53 class mediator
F0045087biological_processinnate immune response
F0048146biological_processpositive regulation of fibroblast proliferation
F0050178molecular_functionphenylpyruvate tautomerase activity
F0050731biological_processpositive regulation of peptidyl-tyrosine phosphorylation
F0050918biological_processpositive chemotaxis
F0051248biological_processnegative regulation of protein metabolic process
F0061078biological_processpositive regulation of prostaglandin secretion involved in immune response
F0061081biological_processpositive regulation of myeloid leukocyte cytokine production involved in immune response
F0070062cellular_componentextracellular exosome
F0070207biological_processprotein homotrimerization
F0070374biological_processpositive regulation of ERK1 and ERK2 cascade
F0090238biological_processpositive regulation of arachidonic acid secretion
F0090398biological_processcellular senescence
F1902166biological_processnegative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
F1904813cellular_componentficolin-1-rich granule lumen
F2000343biological_processpositive regulation of chemokine (C-X-C motif) ligand 2 production
F2000773biological_processnegative regulation of cellular senescence
G0001516biological_processprostaglandin biosynthetic process
G0001819biological_processpositive regulation of cytokine production
G0001934biological_processpositive regulation of protein phosphorylation
G0002020molecular_functionprotease binding
G0002906biological_processnegative regulation of mature B cell apoptotic process
G0004167molecular_functiondopachrome isomerase activity
G0005125molecular_functioncytokine activity
G0005126molecular_functioncytokine receptor binding
G0005515molecular_functionprotein binding
G0005576cellular_componentextracellular region
G0005615cellular_componentextracellular space
G0005654cellular_componentnucleoplasm
G0005737cellular_componentcytoplasm
G0005829cellular_componentcytosol
G0005886cellular_componentplasma membrane
G0006954biological_processinflammatory response
G0007166biological_processcell surface receptor signaling pathway
G0008284biological_processpositive regulation of cell population proliferation
G0009986cellular_componentcell surface
G0010629biological_processnegative regulation of gene expression
G0010739biological_processpositive regulation of protein kinase A signaling
G0010760biological_processnegative regulation of macrophage chemotaxis
G0016853molecular_functionisomerase activity
G0019752biological_processcarboxylic acid metabolic process
G0030330biological_processDNA damage response, signal transduction by p53 class mediator
G0030336biological_processnegative regulation of cell migration
G0030890biological_processpositive regulation of B cell proliferation
G0031666biological_processpositive regulation of lipopolysaccharide-mediated signaling pathway
G0031982cellular_componentvesicle
G0032760biological_processpositive regulation of tumor necrosis factor production
G0033033biological_processnegative regulation of myeloid cell apoptotic process
G0033138biological_processpositive regulation of peptidyl-serine phosphorylation
G0034774cellular_componentsecretory granule lumen
G0042056molecular_functionchemoattractant activity
G0042127biological_processregulation of cell population proliferation
G0042327biological_processpositive regulation of phosphorylation
G0042802molecular_functionidentical protein binding
G0043030biological_processregulation of macrophage activation
G0043066biological_processnegative regulation of apoptotic process
G0043518biological_processnegative regulation of DNA damage response, signal transduction by p53 class mediator
G0045087biological_processinnate immune response
G0048146biological_processpositive regulation of fibroblast proliferation
G0050178molecular_functionphenylpyruvate tautomerase activity
G0050731biological_processpositive regulation of peptidyl-tyrosine phosphorylation
G0050918biological_processpositive chemotaxis
G0051248biological_processnegative regulation of protein metabolic process
G0061078biological_processpositive regulation of prostaglandin secretion involved in immune response
G0061081biological_processpositive regulation of myeloid leukocyte cytokine production involved in immune response
G0070062cellular_componentextracellular exosome
G0070207biological_processprotein homotrimerization
G0070374biological_processpositive regulation of ERK1 and ERK2 cascade
G0090238biological_processpositive regulation of arachidonic acid secretion
G0090398biological_processcellular senescence
G1902166biological_processnegative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
G1904813cellular_componentficolin-1-rich granule lumen
G2000343biological_processpositive regulation of chemokine (C-X-C motif) ligand 2 production
G2000773biological_processnegative regulation of cellular senescence
H0001516biological_processprostaglandin biosynthetic process
H0001819biological_processpositive regulation of cytokine production
H0001934biological_processpositive regulation of protein phosphorylation
H0002020molecular_functionprotease binding
H0002906biological_processnegative regulation of mature B cell apoptotic process
H0004167molecular_functiondopachrome isomerase activity
H0005125molecular_functioncytokine activity
H0005126molecular_functioncytokine receptor binding
H0005515molecular_functionprotein binding
H0005576cellular_componentextracellular region
H0005615cellular_componentextracellular space
H0005654cellular_componentnucleoplasm
H0005737cellular_componentcytoplasm
H0005829cellular_componentcytosol
H0005886cellular_componentplasma membrane
H0006954biological_processinflammatory response
H0007166biological_processcell surface receptor signaling pathway
H0008284biological_processpositive regulation of cell population proliferation
H0009986cellular_componentcell surface
H0010629biological_processnegative regulation of gene expression
H0010739biological_processpositive regulation of protein kinase A signaling
H0010760biological_processnegative regulation of macrophage chemotaxis
H0016853molecular_functionisomerase activity
H0019752biological_processcarboxylic acid metabolic process
H0030330biological_processDNA damage response, signal transduction by p53 class mediator
H0030336biological_processnegative regulation of cell migration
H0030890biological_processpositive regulation of B cell proliferation
H0031666biological_processpositive regulation of lipopolysaccharide-mediated signaling pathway
H0031982cellular_componentvesicle
H0032760biological_processpositive regulation of tumor necrosis factor production
H0033033biological_processnegative regulation of myeloid cell apoptotic process
H0033138biological_processpositive regulation of peptidyl-serine phosphorylation
H0034774cellular_componentsecretory granule lumen
H0042056molecular_functionchemoattractant activity
H0042127biological_processregulation of cell population proliferation
H0042327biological_processpositive regulation of phosphorylation
H0042802molecular_functionidentical protein binding
H0043030biological_processregulation of macrophage activation
H0043066biological_processnegative regulation of apoptotic process
H0043518biological_processnegative regulation of DNA damage response, signal transduction by p53 class mediator
H0045087biological_processinnate immune response
H0048146biological_processpositive regulation of fibroblast proliferation
H0050178molecular_functionphenylpyruvate tautomerase activity
H0050731biological_processpositive regulation of peptidyl-tyrosine phosphorylation
H0050918biological_processpositive chemotaxis
H0051248biological_processnegative regulation of protein metabolic process
H0061078biological_processpositive regulation of prostaglandin secretion involved in immune response
H0061081biological_processpositive regulation of myeloid leukocyte cytokine production involved in immune response
H0070062cellular_componentextracellular exosome
H0070207biological_processprotein homotrimerization
H0070374biological_processpositive regulation of ERK1 and ERK2 cascade
H0090238biological_processpositive regulation of arachidonic acid secretion
H0090398biological_processcellular senescence
H1902166biological_processnegative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
H1904813cellular_componentficolin-1-rich granule lumen
H2000343biological_processpositive regulation of chemokine (C-X-C motif) ligand 2 production
H2000773biological_processnegative regulation of cellular senescence
I0001516biological_processprostaglandin biosynthetic process
I0001819biological_processpositive regulation of cytokine production
I0001934biological_processpositive regulation of protein phosphorylation
I0002020molecular_functionprotease binding
I0002906biological_processnegative regulation of mature B cell apoptotic process
I0004167molecular_functiondopachrome isomerase activity
I0005125molecular_functioncytokine activity
I0005126molecular_functioncytokine receptor binding
I0005515molecular_functionprotein binding
I0005576cellular_componentextracellular region
I0005615cellular_componentextracellular space
I0005654cellular_componentnucleoplasm
I0005737cellular_componentcytoplasm
I0005829cellular_componentcytosol
I0005886cellular_componentplasma membrane
I0006954biological_processinflammatory response
I0007166biological_processcell surface receptor signaling pathway
I0008284biological_processpositive regulation of cell population proliferation
I0009986cellular_componentcell surface
I0010629biological_processnegative regulation of gene expression
I0010739biological_processpositive regulation of protein kinase A signaling
I0010760biological_processnegative regulation of macrophage chemotaxis
I0016853molecular_functionisomerase activity
I0019752biological_processcarboxylic acid metabolic process
I0030330biological_processDNA damage response, signal transduction by p53 class mediator
I0030336biological_processnegative regulation of cell migration
I0030890biological_processpositive regulation of B cell proliferation
I0031666biological_processpositive regulation of lipopolysaccharide-mediated signaling pathway
I0031982cellular_componentvesicle
I0032760biological_processpositive regulation of tumor necrosis factor production
I0033033biological_processnegative regulation of myeloid cell apoptotic process
I0033138biological_processpositive regulation of peptidyl-serine phosphorylation
I0034774cellular_componentsecretory granule lumen
I0042056molecular_functionchemoattractant activity
I0042127biological_processregulation of cell population proliferation
I0042327biological_processpositive regulation of phosphorylation
I0042802molecular_functionidentical protein binding
I0043030biological_processregulation of macrophage activation
I0043066biological_processnegative regulation of apoptotic process
I0043518biological_processnegative regulation of DNA damage response, signal transduction by p53 class mediator
I0045087biological_processinnate immune response
I0048146biological_processpositive regulation of fibroblast proliferation
I0050178molecular_functionphenylpyruvate tautomerase activity
I0050731biological_processpositive regulation of peptidyl-tyrosine phosphorylation
I0050918biological_processpositive chemotaxis
I0051248biological_processnegative regulation of protein metabolic process
I0061078biological_processpositive regulation of prostaglandin secretion involved in immune response
I0061081biological_processpositive regulation of myeloid leukocyte cytokine production involved in immune response
I0070062cellular_componentextracellular exosome
I0070207biological_processprotein homotrimerization
I0070374biological_processpositive regulation of ERK1 and ERK2 cascade
I0090238biological_processpositive regulation of arachidonic acid secretion
I0090398biological_processcellular senescence
I1902166biological_processnegative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
I1904813cellular_componentficolin-1-rich granule lumen
I2000343biological_processpositive regulation of chemokine (C-X-C motif) ligand 2 production
I2000773biological_processnegative regulation of cellular senescence
J0001516biological_processprostaglandin biosynthetic process
J0001819biological_processpositive regulation of cytokine production
J0001934biological_processpositive regulation of protein phosphorylation
J0002020molecular_functionprotease binding
J0002906biological_processnegative regulation of mature B cell apoptotic process
J0004167molecular_functiondopachrome isomerase activity
J0005125molecular_functioncytokine activity
J0005126molecular_functioncytokine receptor binding
J0005515molecular_functionprotein binding
J0005576cellular_componentextracellular region
J0005615cellular_componentextracellular space
J0005654cellular_componentnucleoplasm
J0005737cellular_componentcytoplasm
J0005829cellular_componentcytosol
J0005886cellular_componentplasma membrane
J0006954biological_processinflammatory response
J0007166biological_processcell surface receptor signaling pathway
J0008284biological_processpositive regulation of cell population proliferation
J0009986cellular_componentcell surface
J0010629biological_processnegative regulation of gene expression
J0010739biological_processpositive regulation of protein kinase A signaling
J0010760biological_processnegative regulation of macrophage chemotaxis
J0016853molecular_functionisomerase activity
J0019752biological_processcarboxylic acid metabolic process
J0030330biological_processDNA damage response, signal transduction by p53 class mediator
J0030336biological_processnegative regulation of cell migration
J0030890biological_processpositive regulation of B cell proliferation
J0031666biological_processpositive regulation of lipopolysaccharide-mediated signaling pathway
J0031982cellular_componentvesicle
J0032760biological_processpositive regulation of tumor necrosis factor production
J0033033biological_processnegative regulation of myeloid cell apoptotic process
J0033138biological_processpositive regulation of peptidyl-serine phosphorylation
J0034774cellular_componentsecretory granule lumen
J0042056molecular_functionchemoattractant activity
J0042127biological_processregulation of cell population proliferation
J0042327biological_processpositive regulation of phosphorylation
J0042802molecular_functionidentical protein binding
J0043030biological_processregulation of macrophage activation
J0043066biological_processnegative regulation of apoptotic process
J0043518biological_processnegative regulation of DNA damage response, signal transduction by p53 class mediator
J0045087biological_processinnate immune response
J0048146biological_processpositive regulation of fibroblast proliferation
J0050178molecular_functionphenylpyruvate tautomerase activity
J0050731biological_processpositive regulation of peptidyl-tyrosine phosphorylation
J0050918biological_processpositive chemotaxis
J0051248biological_processnegative regulation of protein metabolic process
J0061078biological_processpositive regulation of prostaglandin secretion involved in immune response
J0061081biological_processpositive regulation of myeloid leukocyte cytokine production involved in immune response
J0070062cellular_componentextracellular exosome
J0070207biological_processprotein homotrimerization
J0070374biological_processpositive regulation of ERK1 and ERK2 cascade
J0090238biological_processpositive regulation of arachidonic acid secretion
J0090398biological_processcellular senescence
J1902166biological_processnegative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
J1904813cellular_componentficolin-1-rich granule lumen
J2000343biological_processpositive regulation of chemokine (C-X-C motif) ligand 2 production
J2000773biological_processnegative regulation of cellular senescence
K0001516biological_processprostaglandin biosynthetic process
K0001819biological_processpositive regulation of cytokine production
K0001934biological_processpositive regulation of protein phosphorylation
K0002020molecular_functionprotease binding
K0002906biological_processnegative regulation of mature B cell apoptotic process
K0004167molecular_functiondopachrome isomerase activity
K0005125molecular_functioncytokine activity
K0005126molecular_functioncytokine receptor binding
K0005515molecular_functionprotein binding
K0005576cellular_componentextracellular region
K0005615cellular_componentextracellular space
K0005654cellular_componentnucleoplasm
K0005737cellular_componentcytoplasm
K0005829cellular_componentcytosol
K0005886cellular_componentplasma membrane
K0006954biological_processinflammatory response
K0007166biological_processcell surface receptor signaling pathway
K0008284biological_processpositive regulation of cell population proliferation
K0009986cellular_componentcell surface
K0010629biological_processnegative regulation of gene expression
K0010739biological_processpositive regulation of protein kinase A signaling
K0010760biological_processnegative regulation of macrophage chemotaxis
K0016853molecular_functionisomerase activity
K0019752biological_processcarboxylic acid metabolic process
K0030330biological_processDNA damage response, signal transduction by p53 class mediator
K0030336biological_processnegative regulation of cell migration
K0030890biological_processpositive regulation of B cell proliferation
K0031666biological_processpositive regulation of lipopolysaccharide-mediated signaling pathway
K0031982cellular_componentvesicle
K0032760biological_processpositive regulation of tumor necrosis factor production
K0033033biological_processnegative regulation of myeloid cell apoptotic process
K0033138biological_processpositive regulation of peptidyl-serine phosphorylation
K0034774cellular_componentsecretory granule lumen
K0042056molecular_functionchemoattractant activity
K0042127biological_processregulation of cell population proliferation
K0042327biological_processpositive regulation of phosphorylation
K0042802molecular_functionidentical protein binding
K0043030biological_processregulation of macrophage activation
K0043066biological_processnegative regulation of apoptotic process
K0043518biological_processnegative regulation of DNA damage response, signal transduction by p53 class mediator
K0045087biological_processinnate immune response
K0048146biological_processpositive regulation of fibroblast proliferation
K0050178molecular_functionphenylpyruvate tautomerase activity
K0050731biological_processpositive regulation of peptidyl-tyrosine phosphorylation
K0050918biological_processpositive chemotaxis
K0051248biological_processnegative regulation of protein metabolic process
K0061078biological_processpositive regulation of prostaglandin secretion involved in immune response
K0061081biological_processpositive regulation of myeloid leukocyte cytokine production involved in immune response
K0070062cellular_componentextracellular exosome
K0070207biological_processprotein homotrimerization
K0070374biological_processpositive regulation of ERK1 and ERK2 cascade
K0090238biological_processpositive regulation of arachidonic acid secretion
K0090398biological_processcellular senescence
K1902166biological_processnegative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
K1904813cellular_componentficolin-1-rich granule lumen
K2000343biological_processpositive regulation of chemokine (C-X-C motif) ligand 2 production
K2000773biological_processnegative regulation of cellular senescence
L0001516biological_processprostaglandin biosynthetic process
L0001819biological_processpositive regulation of cytokine production
L0001934biological_processpositive regulation of protein phosphorylation
L0002020molecular_functionprotease binding
L0002906biological_processnegative regulation of mature B cell apoptotic process
L0004167molecular_functiondopachrome isomerase activity
L0005125molecular_functioncytokine activity
L0005126molecular_functioncytokine receptor binding
L0005515molecular_functionprotein binding
L0005576cellular_componentextracellular region
L0005615cellular_componentextracellular space
L0005654cellular_componentnucleoplasm
L0005737cellular_componentcytoplasm
L0005829cellular_componentcytosol
L0005886cellular_componentplasma membrane
L0006954biological_processinflammatory response
L0007166biological_processcell surface receptor signaling pathway
L0008284biological_processpositive regulation of cell population proliferation
L0009986cellular_componentcell surface
L0010629biological_processnegative regulation of gene expression
L0010739biological_processpositive regulation of protein kinase A signaling
L0010760biological_processnegative regulation of macrophage chemotaxis
L0016853molecular_functionisomerase activity
L0019752biological_processcarboxylic acid metabolic process
L0030330biological_processDNA damage response, signal transduction by p53 class mediator
L0030336biological_processnegative regulation of cell migration
L0030890biological_processpositive regulation of B cell proliferation
L0031666biological_processpositive regulation of lipopolysaccharide-mediated signaling pathway
L0031982cellular_componentvesicle
L0032760biological_processpositive regulation of tumor necrosis factor production
L0033033biological_processnegative regulation of myeloid cell apoptotic process
L0033138biological_processpositive regulation of peptidyl-serine phosphorylation
L0034774cellular_componentsecretory granule lumen
L0042056molecular_functionchemoattractant activity
L0042127biological_processregulation of cell population proliferation
L0042327biological_processpositive regulation of phosphorylation
L0042802molecular_functionidentical protein binding
L0043030biological_processregulation of macrophage activation
L0043066biological_processnegative regulation of apoptotic process
L0043518biological_processnegative regulation of DNA damage response, signal transduction by p53 class mediator
L0045087biological_processinnate immune response
L0048146biological_processpositive regulation of fibroblast proliferation
L0050178molecular_functionphenylpyruvate tautomerase activity
L0050731biological_processpositive regulation of peptidyl-tyrosine phosphorylation
L0050918biological_processpositive chemotaxis
L0051248biological_processnegative regulation of protein metabolic process
L0061078biological_processpositive regulation of prostaglandin secretion involved in immune response
L0061081biological_processpositive regulation of myeloid leukocyte cytokine production involved in immune response
L0070062cellular_componentextracellular exosome
L0070207biological_processprotein homotrimerization
L0070374biological_processpositive regulation of ERK1 and ERK2 cascade
L0090238biological_processpositive regulation of arachidonic acid secretion
L0090398biological_processcellular senescence
L1902166biological_processnegative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
L1904813cellular_componentficolin-1-rich granule lumen
L2000343biological_processpositive regulation of chemokine (C-X-C motif) ligand 2 production
L2000773biological_processnegative regulation of cellular senescence
M0001516biological_processprostaglandin biosynthetic process
M0001819biological_processpositive regulation of cytokine production
M0001934biological_processpositive regulation of protein phosphorylation
M0002020molecular_functionprotease binding
M0002906biological_processnegative regulation of mature B cell apoptotic process
M0004167molecular_functiondopachrome isomerase activity
M0005125molecular_functioncytokine activity
M0005126molecular_functioncytokine receptor binding
M0005515molecular_functionprotein binding
M0005576cellular_componentextracellular region
M0005615cellular_componentextracellular space
M0005654cellular_componentnucleoplasm
M0005737cellular_componentcytoplasm
M0005829cellular_componentcytosol
M0005886cellular_componentplasma membrane
M0006954biological_processinflammatory response
M0007166biological_processcell surface receptor signaling pathway
M0008284biological_processpositive regulation of cell population proliferation
M0009986cellular_componentcell surface
M0010629biological_processnegative regulation of gene expression
M0010739biological_processpositive regulation of protein kinase A signaling
M0010760biological_processnegative regulation of macrophage chemotaxis
M0016853molecular_functionisomerase activity
M0019752biological_processcarboxylic acid metabolic process
M0030330biological_processDNA damage response, signal transduction by p53 class mediator
M0030336biological_processnegative regulation of cell migration
M0030890biological_processpositive regulation of B cell proliferation
M0031666biological_processpositive regulation of lipopolysaccharide-mediated signaling pathway
M0031982cellular_componentvesicle
M0032760biological_processpositive regulation of tumor necrosis factor production
M0033033biological_processnegative regulation of myeloid cell apoptotic process
M0033138biological_processpositive regulation of peptidyl-serine phosphorylation
M0034774cellular_componentsecretory granule lumen
M0042056molecular_functionchemoattractant activity
M0042127biological_processregulation of cell population proliferation
M0042327biological_processpositive regulation of phosphorylation
M0042802molecular_functionidentical protein binding
M0043030biological_processregulation of macrophage activation
M0043066biological_processnegative regulation of apoptotic process
M0043518biological_processnegative regulation of DNA damage response, signal transduction by p53 class mediator
M0045087biological_processinnate immune response
M0048146biological_processpositive regulation of fibroblast proliferation
M0050178molecular_functionphenylpyruvate tautomerase activity
M0050731biological_processpositive regulation of peptidyl-tyrosine phosphorylation
M0050918biological_processpositive chemotaxis
M0051248biological_processnegative regulation of protein metabolic process
M0061078biological_processpositive regulation of prostaglandin secretion involved in immune response
M0061081biological_processpositive regulation of myeloid leukocyte cytokine production involved in immune response
M0070062cellular_componentextracellular exosome
M0070207biological_processprotein homotrimerization
M0070374biological_processpositive regulation of ERK1 and ERK2 cascade
M0090238biological_processpositive regulation of arachidonic acid secretion
M0090398biological_processcellular senescence
M1902166biological_processnegative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
M1904813cellular_componentficolin-1-rich granule lumen
M2000343biological_processpositive regulation of chemokine (C-X-C motif) ligand 2 production
M2000773biological_processnegative regulation of cellular senescence
N0001516biological_processprostaglandin biosynthetic process
N0001819biological_processpositive regulation of cytokine production
N0001934biological_processpositive regulation of protein phosphorylation
N0002020molecular_functionprotease binding
N0002906biological_processnegative regulation of mature B cell apoptotic process
N0004167molecular_functiondopachrome isomerase activity
N0005125molecular_functioncytokine activity
N0005126molecular_functioncytokine receptor binding
N0005515molecular_functionprotein binding
N0005576cellular_componentextracellular region
N0005615cellular_componentextracellular space
N0005654cellular_componentnucleoplasm
N0005737cellular_componentcytoplasm
N0005829cellular_componentcytosol
N0005886cellular_componentplasma membrane
N0006954biological_processinflammatory response
N0007166biological_processcell surface receptor signaling pathway
N0008284biological_processpositive regulation of cell population proliferation
N0009986cellular_componentcell surface
N0010629biological_processnegative regulation of gene expression
N0010739biological_processpositive regulation of protein kinase A signaling
N0010760biological_processnegative regulation of macrophage chemotaxis
N0016853molecular_functionisomerase activity
N0019752biological_processcarboxylic acid metabolic process
N0030330biological_processDNA damage response, signal transduction by p53 class mediator
N0030336biological_processnegative regulation of cell migration
N0030890biological_processpositive regulation of B cell proliferation
N0031666biological_processpositive regulation of lipopolysaccharide-mediated signaling pathway
N0031982cellular_componentvesicle
N0032760biological_processpositive regulation of tumor necrosis factor production
N0033033biological_processnegative regulation of myeloid cell apoptotic process
N0033138biological_processpositive regulation of peptidyl-serine phosphorylation
N0034774cellular_componentsecretory granule lumen
N0042056molecular_functionchemoattractant activity
N0042127biological_processregulation of cell population proliferation
N0042327biological_processpositive regulation of phosphorylation
N0042802molecular_functionidentical protein binding
N0043030biological_processregulation of macrophage activation
N0043066biological_processnegative regulation of apoptotic process
N0043518biological_processnegative regulation of DNA damage response, signal transduction by p53 class mediator
N0045087biological_processinnate immune response
N0048146biological_processpositive regulation of fibroblast proliferation
N0050178molecular_functionphenylpyruvate tautomerase activity
N0050731biological_processpositive regulation of peptidyl-tyrosine phosphorylation
N0050918biological_processpositive chemotaxis
N0051248biological_processnegative regulation of protein metabolic process
N0061078biological_processpositive regulation of prostaglandin secretion involved in immune response
N0061081biological_processpositive regulation of myeloid leukocyte cytokine production involved in immune response
N0070062cellular_componentextracellular exosome
N0070207biological_processprotein homotrimerization
N0070374biological_processpositive regulation of ERK1 and ERK2 cascade
N0090238biological_processpositive regulation of arachidonic acid secretion
N0090398biological_processcellular senescence
N1902166biological_processnegative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
N1904813cellular_componentficolin-1-rich granule lumen
N2000343biological_processpositive regulation of chemokine (C-X-C motif) ligand 2 production
N2000773biological_processnegative regulation of cellular senescence
O0001516biological_processprostaglandin biosynthetic process
O0001819biological_processpositive regulation of cytokine production
O0001934biological_processpositive regulation of protein phosphorylation
O0002020molecular_functionprotease binding
O0002906biological_processnegative regulation of mature B cell apoptotic process
O0004167molecular_functiondopachrome isomerase activity
O0005125molecular_functioncytokine activity
O0005126molecular_functioncytokine receptor binding
O0005515molecular_functionprotein binding
O0005576cellular_componentextracellular region
O0005615cellular_componentextracellular space
O0005654cellular_componentnucleoplasm
O0005737cellular_componentcytoplasm
O0005829cellular_componentcytosol
O0005886cellular_componentplasma membrane
O0006954biological_processinflammatory response
O0007166biological_processcell surface receptor signaling pathway
O0008284biological_processpositive regulation of cell population proliferation
O0009986cellular_componentcell surface
O0010629biological_processnegative regulation of gene expression
O0010739biological_processpositive regulation of protein kinase A signaling
O0010760biological_processnegative regulation of macrophage chemotaxis
O0016853molecular_functionisomerase activity
O0019752biological_processcarboxylic acid metabolic process
O0030330biological_processDNA damage response, signal transduction by p53 class mediator
O0030336biological_processnegative regulation of cell migration
O0030890biological_processpositive regulation of B cell proliferation
O0031666biological_processpositive regulation of lipopolysaccharide-mediated signaling pathway
O0031982cellular_componentvesicle
O0032760biological_processpositive regulation of tumor necrosis factor production
O0033033biological_processnegative regulation of myeloid cell apoptotic process
O0033138biological_processpositive regulation of peptidyl-serine phosphorylation
O0034774cellular_componentsecretory granule lumen
O0042056molecular_functionchemoattractant activity
O0042127biological_processregulation of cell population proliferation
O0042327biological_processpositive regulation of phosphorylation
O0042802molecular_functionidentical protein binding
O0043030biological_processregulation of macrophage activation
O0043066biological_processnegative regulation of apoptotic process
O0043518biological_processnegative regulation of DNA damage response, signal transduction by p53 class mediator
O0045087biological_processinnate immune response
O0048146biological_processpositive regulation of fibroblast proliferation
O0050178molecular_functionphenylpyruvate tautomerase activity
O0050731biological_processpositive regulation of peptidyl-tyrosine phosphorylation
O0050918biological_processpositive chemotaxis
O0051248biological_processnegative regulation of protein metabolic process
O0061078biological_processpositive regulation of prostaglandin secretion involved in immune response
O0061081biological_processpositive regulation of myeloid leukocyte cytokine production involved in immune response
O0070062cellular_componentextracellular exosome
O0070207biological_processprotein homotrimerization
O0070374biological_processpositive regulation of ERK1 and ERK2 cascade
O0090238biological_processpositive regulation of arachidonic acid secretion
O0090398biological_processcellular senescence
O1902166biological_processnegative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
O1904813cellular_componentficolin-1-rich granule lumen
O2000343biological_processpositive regulation of chemokine (C-X-C motif) ligand 2 production
O2000773biological_processnegative regulation of cellular senescence
P0001516biological_processprostaglandin biosynthetic process
P0001819biological_processpositive regulation of cytokine production
P0001934biological_processpositive regulation of protein phosphorylation
P0002020molecular_functionprotease binding
P0002906biological_processnegative regulation of mature B cell apoptotic process
P0004167molecular_functiondopachrome isomerase activity
P0005125molecular_functioncytokine activity
P0005126molecular_functioncytokine receptor binding
P0005515molecular_functionprotein binding
P0005576cellular_componentextracellular region
P0005615cellular_componentextracellular space
P0005654cellular_componentnucleoplasm
P0005737cellular_componentcytoplasm
P0005829cellular_componentcytosol
P0005886cellular_componentplasma membrane
P0006954biological_processinflammatory response
P0007166biological_processcell surface receptor signaling pathway
P0008284biological_processpositive regulation of cell population proliferation
P0009986cellular_componentcell surface
P0010629biological_processnegative regulation of gene expression
P0010739biological_processpositive regulation of protein kinase A signaling
P0010760biological_processnegative regulation of macrophage chemotaxis
P0016853molecular_functionisomerase activity
P0019752biological_processcarboxylic acid metabolic process
P0030330biological_processDNA damage response, signal transduction by p53 class mediator
P0030336biological_processnegative regulation of cell migration
P0030890biological_processpositive regulation of B cell proliferation
P0031666biological_processpositive regulation of lipopolysaccharide-mediated signaling pathway
P0031982cellular_componentvesicle
P0032760biological_processpositive regulation of tumor necrosis factor production
P0033033biological_processnegative regulation of myeloid cell apoptotic process
P0033138biological_processpositive regulation of peptidyl-serine phosphorylation
P0034774cellular_componentsecretory granule lumen
P0042056molecular_functionchemoattractant activity
P0042127biological_processregulation of cell population proliferation
P0042327biological_processpositive regulation of phosphorylation
P0042802molecular_functionidentical protein binding
P0043030biological_processregulation of macrophage activation
P0043066biological_processnegative regulation of apoptotic process
P0043518biological_processnegative regulation of DNA damage response, signal transduction by p53 class mediator
P0045087biological_processinnate immune response
P0048146biological_processpositive regulation of fibroblast proliferation
P0050178molecular_functionphenylpyruvate tautomerase activity
P0050731biological_processpositive regulation of peptidyl-tyrosine phosphorylation
P0050918biological_processpositive chemotaxis
P0051248biological_processnegative regulation of protein metabolic process
P0061078biological_processpositive regulation of prostaglandin secretion involved in immune response
P0061081biological_processpositive regulation of myeloid leukocyte cytokine production involved in immune response
P0070062cellular_componentextracellular exosome
P0070207biological_processprotein homotrimerization
P0070374biological_processpositive regulation of ERK1 and ERK2 cascade
P0090238biological_processpositive regulation of arachidonic acid secretion
P0090398biological_processcellular senescence
P1902166biological_processnegative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
P1904813cellular_componentficolin-1-rich granule lumen
P2000343biological_processpositive regulation of chemokine (C-X-C motif) ligand 2 production
P2000773biological_processnegative regulation of cellular senescence
Q0001516biological_processprostaglandin biosynthetic process
Q0001819biological_processpositive regulation of cytokine production
Q0001934biological_processpositive regulation of protein phosphorylation
Q0002020molecular_functionprotease binding
Q0002906biological_processnegative regulation of mature B cell apoptotic process
Q0004167molecular_functiondopachrome isomerase activity
Q0005125molecular_functioncytokine activity
Q0005126molecular_functioncytokine receptor binding
Q0005515molecular_functionprotein binding
Q0005576cellular_componentextracellular region
Q0005615cellular_componentextracellular space
Q0005654cellular_componentnucleoplasm
Q0005737cellular_componentcytoplasm
Q0005829cellular_componentcytosol
Q0005886cellular_componentplasma membrane
Q0006954biological_processinflammatory response
Q0007166biological_processcell surface receptor signaling pathway
Q0008284biological_processpositive regulation of cell population proliferation
Q0009986cellular_componentcell surface
Q0010629biological_processnegative regulation of gene expression
Q0010739biological_processpositive regulation of protein kinase A signaling
Q0010760biological_processnegative regulation of macrophage chemotaxis
Q0016853molecular_functionisomerase activity
Q0019752biological_processcarboxylic acid metabolic process
Q0030330biological_processDNA damage response, signal transduction by p53 class mediator
Q0030336biological_processnegative regulation of cell migration
Q0030890biological_processpositive regulation of B cell proliferation
Q0031666biological_processpositive regulation of lipopolysaccharide-mediated signaling pathway
Q0031982cellular_componentvesicle
Q0032760biological_processpositive regulation of tumor necrosis factor production
Q0033033biological_processnegative regulation of myeloid cell apoptotic process
Q0033138biological_processpositive regulation of peptidyl-serine phosphorylation
Q0034774cellular_componentsecretory granule lumen
Q0042056molecular_functionchemoattractant activity
Q0042127biological_processregulation of cell population proliferation
Q0042327biological_processpositive regulation of phosphorylation
Q0042802molecular_functionidentical protein binding
Q0043030biological_processregulation of macrophage activation
Q0043066biological_processnegative regulation of apoptotic process
Q0043518biological_processnegative regulation of DNA damage response, signal transduction by p53 class mediator
Q0045087biological_processinnate immune response
Q0048146biological_processpositive regulation of fibroblast proliferation
Q0050178molecular_functionphenylpyruvate tautomerase activity
Q0050731biological_processpositive regulation of peptidyl-tyrosine phosphorylation
Q0050918biological_processpositive chemotaxis
Q0051248biological_processnegative regulation of protein metabolic process
Q0061078biological_processpositive regulation of prostaglandin secretion involved in immune response
Q0061081biological_processpositive regulation of myeloid leukocyte cytokine production involved in immune response
Q0070062cellular_componentextracellular exosome
Q0070207biological_processprotein homotrimerization
Q0070374biological_processpositive regulation of ERK1 and ERK2 cascade
Q0090238biological_processpositive regulation of arachidonic acid secretion
Q0090398biological_processcellular senescence
Q1902166biological_processnegative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
Q1904813cellular_componentficolin-1-rich granule lumen
Q2000343biological_processpositive regulation of chemokine (C-X-C motif) ligand 2 production
Q2000773biological_processnegative regulation of cellular senescence
R0001516biological_processprostaglandin biosynthetic process
R0001819biological_processpositive regulation of cytokine production
R0001934biological_processpositive regulation of protein phosphorylation
R0002020molecular_functionprotease binding
R0002906biological_processnegative regulation of mature B cell apoptotic process
R0004167molecular_functiondopachrome isomerase activity
R0005125molecular_functioncytokine activity
R0005126molecular_functioncytokine receptor binding
R0005515molecular_functionprotein binding
R0005576cellular_componentextracellular region
R0005615cellular_componentextracellular space
R0005654cellular_componentnucleoplasm
R0005737cellular_componentcytoplasm
R0005829cellular_componentcytosol
R0005886cellular_componentplasma membrane
R0006954biological_processinflammatory response
R0007166biological_processcell surface receptor signaling pathway
R0008284biological_processpositive regulation of cell population proliferation
R0009986cellular_componentcell surface
R0010629biological_processnegative regulation of gene expression
R0010739biological_processpositive regulation of protein kinase A signaling
R0010760biological_processnegative regulation of macrophage chemotaxis
R0016853molecular_functionisomerase activity
R0019752biological_processcarboxylic acid metabolic process
R0030330biological_processDNA damage response, signal transduction by p53 class mediator
R0030336biological_processnegative regulation of cell migration
R0030890biological_processpositive regulation of B cell proliferation
R0031666biological_processpositive regulation of lipopolysaccharide-mediated signaling pathway
R0031982cellular_componentvesicle
R0032760biological_processpositive regulation of tumor necrosis factor production
R0033033biological_processnegative regulation of myeloid cell apoptotic process
R0033138biological_processpositive regulation of peptidyl-serine phosphorylation
R0034774cellular_componentsecretory granule lumen
R0042056molecular_functionchemoattractant activity
R0042127biological_processregulation of cell population proliferation
R0042327biological_processpositive regulation of phosphorylation
R0042802molecular_functionidentical protein binding
R0043030biological_processregulation of macrophage activation
R0043066biological_processnegative regulation of apoptotic process
R0043518biological_processnegative regulation of DNA damage response, signal transduction by p53 class mediator
R0045087biological_processinnate immune response
R0048146biological_processpositive regulation of fibroblast proliferation
R0050178molecular_functionphenylpyruvate tautomerase activity
R0050731biological_processpositive regulation of peptidyl-tyrosine phosphorylation
R0050918biological_processpositive chemotaxis
R0051248biological_processnegative regulation of protein metabolic process
R0061078biological_processpositive regulation of prostaglandin secretion involved in immune response
R0061081biological_processpositive regulation of myeloid leukocyte cytokine production involved in immune response
R0070062cellular_componentextracellular exosome
R0070207biological_processprotein homotrimerization
R0070374biological_processpositive regulation of ERK1 and ERK2 cascade
R0090238biological_processpositive regulation of arachidonic acid secretion
R0090398biological_processcellular senescence
R1902166biological_processnegative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
R1904813cellular_componentficolin-1-rich granule lumen
R2000343biological_processpositive regulation of chemokine (C-X-C motif) ligand 2 production
R2000773biological_processnegative regulation of cellular senescence
Functional Information from PDB Data
site_idAC1
Number of Residues4
Detailsbinding site for residue SO4 A 201
ChainResidue
AGLY68
AGLY69
AALA70
AGLN71

site_idAC2
Number of Residues3
Detailsbinding site for residue SO4 A 202
ChainResidue
AMET101
AASN102
AALA103

site_idAC3
Number of Residues5
Detailsbinding site for residue SO4 A 203
ChainResidue
APHE18
ALEU19
ASER20
AASP16
AGLY17

site_idAC4
Number of Residues4
Detailsbinding site for residue SO4 B 201
ChainResidue
BGLY68
BGLY69
BALA70
BGLN71

site_idAC5
Number of Residues4
Detailsbinding site for residue SO4 B 202
ChainResidue
BGLY65
BLYS66
BILE67
BGLN71

site_idAC6
Number of Residues5
Detailsbinding site for residue SO4 B 203
ChainResidue
BASP16
BGLY17
BPHE18
BLEU19
BSER20

site_idAC7
Number of Residues14
Detailsbinding site for residue 3TX C 201
ChainResidue
BTYR95
BASN97
CPRO1
CMET2
CLYS32
CPRO33
CTYR36
CHIS62
CSER63
CILE64
CVAL106
CPHE113
FPHE113
F3TX201

site_idAC8
Number of Residues4
Detailsbinding site for residue SO4 C 202
ChainResidue
CGLY68
CGLY69
CALA70
CGLN71

site_idAC9
Number of Residues5
Detailsbinding site for residue SO4 C 203
ChainResidue
BLYS66
CGLY69
CALA70
CARG73
CHOH301

site_idAD1
Number of Residues5
Detailsbinding site for residue SO4 C 204
ChainResidue
CASP16
CGLY17
CPHE18
CLEU19
CSER20

site_idAD2
Number of Residues4
Detailsbinding site for residue SO4 D 201
ChainResidue
DGLY68
DGLY69
DALA70
DGLN71

site_idAD3
Number of Residues2
Detailsbinding site for residue SO4 D 202
ChainResidue
DASN102
DALA103

site_idAD4
Number of Residues5
Detailsbinding site for residue SO4 D 203
ChainResidue
DASP16
DGLY17
DPHE18
DLEU19
DSER20

site_idAD5
Number of Residues4
Detailsbinding site for residue SO4 E 201
ChainResidue
EGLY68
EGLY69
EALA70
EGLN71

site_idAD6
Number of Residues4
Detailsbinding site for residue SO4 E 202
ChainResidue
EGLY65
ELYS66
EILE67
EGLN71

site_idAD7
Number of Residues4
Detailsbinding site for residue SO4 E 203
ChainResidue
EGLY17
EPHE18
ELEU19
ESER20

site_idAD8
Number of Residues13
Detailsbinding site for residue 3TX F 201
ChainResidue
CPHE113
C3TX201
ETYR95
EASN97
FPRO1
FMET2
FLYS32
FPRO33
FTYR36
FSER63
FILE64
FVAL106
FPHE113

site_idAD9
Number of Residues4
Detailsbinding site for residue SO4 F 202
ChainResidue
FGLY68
FGLY69
FALA70
FGLN71

site_idAE1
Number of Residues4
Detailsbinding site for residue SO4 F 203
ChainResidue
ELYS66
FGLY69
FARG73
FHOH301

site_idAE2
Number of Residues5
Detailsbinding site for residue SO4 F 204
ChainResidue
FPHE18
FLEU19
FSER20
FASP16
FGLY17

site_idAE3
Number of Residues5
Detailsbinding site for residue SO4 G 201
ChainResidue
GGLY68
GGLY69
GALA70
GGLN71
GHOH315

site_idAE4
Number of Residues6
Detailsbinding site for residue SO4 G 202
ChainResidue
GPRO15
GASP16
GGLY17
GPHE18
GLEU19
GSER20

site_idAE5
Number of Residues2
Detailsbinding site for residue SO4 G 203
ChainResidue
GASN102
GALA103

site_idAE6
Number of Residues4
Detailsbinding site for residue SO4 H 201
ChainResidue
HGLY68
HGLY69
HALA70
HGLN71

site_idAE7
Number of Residues3
Detailsbinding site for residue SO4 H 202
ChainResidue
HLYS66
HILE67
HGLN71

site_idAE8
Number of Residues5
Detailsbinding site for residue SO4 H 203
ChainResidue
HASP16
HGLY17
HPHE18
HLEU19
HSER20

site_idAE9
Number of Residues13
Detailsbinding site for residue 3TX I 201
ChainResidue
HTYR95
HASN97
IPRO1
IMET2
ILYS32
IPRO33
ITYR36
IHIS62
IILE64
IVAL106
IPHE113
RPHE113
R3TX201

site_idAF1
Number of Residues4
Detailsbinding site for residue SO4 I 202
ChainResidue
IGLY68
IGLY69
IALA70
IGLN71

site_idAF2
Number of Residues5
Detailsbinding site for residue SO4 I 203
ChainResidue
HLYS66
IGLY69
IALA70
IARG73
IHOH301

site_idAF3
Number of Residues4
Detailsbinding site for residue SO4 I 204
ChainResidue
IGLY17
IPHE18
ILEU19
ISER20

site_idAF4
Number of Residues4
Detailsbinding site for residue SO4 J 201
ChainResidue
JGLY68
JGLY69
JALA70
JGLN71

site_idAF5
Number of Residues5
Detailsbinding site for residue SO4 J 202
ChainResidue
JASP16
JGLY17
JPHE18
JLEU19
JSER20

site_idAF6
Number of Residues2
Detailsbinding site for residue SO4 J 203
ChainResidue
DARG88
JARG88

site_idAF7
Number of Residues3
Detailsbinding site for residue SO4 K 201
ChainResidue
KGLY68
KALA70
KGLN71

site_idAF8
Number of Residues3
Detailsbinding site for residue SO4 K 202
ChainResidue
KLYS66
KILE67
KGLN71

site_idAF9
Number of Residues5
Detailsbinding site for residue SO4 K 203
ChainResidue
KASP16
KGLY17
KPHE18
KLEU19
KSER20

site_idAG1
Number of Residues13
Detailsbinding site for residue 3TX L 201
ChainResidue
KTYR95
KASN97
LPRO1
LMET2
LLYS32
LPRO33
LTYR36
LHIS62
LILE64
LVAL106
LPHE113
OPHE113
O3TX201

site_idAG2
Number of Residues4
Detailsbinding site for residue SO4 L 202
ChainResidue
LGLY68
LGLY69
LALA70
LGLN71

site_idAG3
Number of Residues4
Detailsbinding site for residue SO4 L 203
ChainResidue
KLYS66
LGLY69
LALA70
LARG73

site_idAG4
Number of Residues5
Detailsbinding site for residue SO4 L 204
ChainResidue
LASP16
LGLY17
LPHE18
LLEU19
LSER20

site_idAG5
Number of Residues4
Detailsbinding site for residue SO4 M 201
ChainResidue
MGLY68
MGLY69
MALA70
MGLN71

site_idAG6
Number of Residues6
Detailsbinding site for residue SO4 M 202
ChainResidue
MPRO15
MASP16
MGLY17
MPHE18
MLEU19
MSER20

site_idAG7
Number of Residues5
Detailsbinding site for residue SO4 N 201
ChainResidue
NGLY68
NGLY69
NALA70
NGLN71
NHOH301

site_idAG8
Number of Residues3
Detailsbinding site for residue SO4 N 202
ChainResidue
NLYS66
NILE67
NGLN71

site_idAG9
Number of Residues4
Detailsbinding site for residue SO4 N 203
ChainResidue
NGLY17
NPHE18
NLEU19
NSER20

site_idAH1
Number of Residues13
Detailsbinding site for residue 3TX O 201
ChainResidue
LPHE113
L3TX201
NTYR95
NASN97
OPRO1
OMET2
OLYS32
OPRO33
OTYR36
OHIS62
OSER63
OILE64
OPHE113

site_idAH2
Number of Residues5
Detailsbinding site for residue SO4 O 202
ChainResidue
KARG73
OGLY68
OGLY69
OALA70
OGLN71

site_idAH3
Number of Residues4
Detailsbinding site for residue SO4 O 203
ChainResidue
NLYS66
OGLY69
OARG73
OHOH301

site_idAH4
Number of Residues4
Detailsbinding site for residue SO4 O 204
ChainResidue
OGLY17
OPHE18
OLEU19
OSER20

site_idAH5
Number of Residues4
Detailsbinding site for residue SO4 P 201
ChainResidue
PGLY68
PGLY69
PALA70
PGLN71

site_idAH6
Number of Residues2
Detailsbinding site for residue SO4 P 202
ChainResidue
PASN102
PALA103

site_idAH7
Number of Residues6
Detailsbinding site for residue SO4 P 203
ChainResidue
PPRO15
PASP16
PGLY17
PPHE18
PLEU19
PSER20

site_idAH8
Number of Residues4
Detailsbinding site for residue SO4 Q 201
ChainResidue
QGLY68
QGLY69
QALA70
QGLN71

site_idAH9
Number of Residues4
Detailsbinding site for residue SO4 Q 202
ChainResidue
QGLY65
QLYS66
QILE67
QGLN71

site_idAI1
Number of Residues5
Detailsbinding site for residue SO4 Q 203
ChainResidue
QASP16
QGLY17
QPHE18
QLEU19
QSER20

site_idAI2
Number of Residues15
Detailsbinding site for residue 3TX R 201
ChainResidue
ITRP108
IPHE113
I3TX201
QTYR95
QASN97
RPRO1
RMET2
RLYS32
RPRO33
RTYR36
RHIS62
RSER63
RILE64
RVAL106
RPHE113

site_idAI3
Number of Residues6
Detailsbinding site for residue SO4 R 202
ChainResidue
RGLY68
RGLY69
RALA70
RGLN71
RSO4203
RHOH312

site_idAI4
Number of Residues5
Detailsbinding site for residue SO4 R 203
ChainResidue
QLYS66
RGLY69
RALA70
RARG73
RSO4202

site_idAI5
Number of Residues5
Detailsbinding site for residue SO4 R 204
ChainResidue
RASP16
RGLY17
RPHE18
RLEU19
RSER20

Functional Information from PROSITE/UniProt
site_idPS01158
Number of Residues15
DetailsMIF Macrophage migration inhibitory factor family signature. EPCAlcsLhSIGkIG
ChainResidueDetails
AGLU54-GLY68

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues18
DetailsACT_SITE: Proton acceptor; via imino nitrogen => ECO:0000250|UniProtKB:P34884
ChainResidueDetails
APRO1
BPRO1
CPRO1
DPRO1
EPRO1
FPRO1
GPRO1
HPRO1
IPRO1
JPRO1
KPRO1
LPRO1
MPRO1
NPRO1
OPRO1
PPRO1
QPRO1
RPRO1

site_idSWS_FT_FI2
Number of Residues54
DetailsBINDING: BINDING => ECO:0000269|PubMed:11170644, ECO:0000269|PubMed:17526494, ECO:0000269|PubMed:19090677
ChainResidueDetails
MLYS32
MILE64
MASN97
NLYS32
NILE64
NASN97
OLYS32
OILE64
OASN97
PLYS32
PILE64
PASN97
QLYS32
QILE64
QASN97
RLYS32
RILE64
RASN97
EILE64
EASN97
FLYS32
FILE64
FASN97
GLYS32
GILE64
GASN97
HLYS32
HILE64
HASN97
ILYS32
IILE64
IASN97
JLYS32
JILE64
JASN97
KLYS32
KILE64
KASN97
LLYS32
LILE64
LASN97
ALYS32
AILE64
AASN97
BLYS32
BILE64
BASN97
CLYS32
CILE64
CASN97
DLYS32
DILE64
DASN97
ELYS32

site_idSWS_FT_FI3
Number of Residues18
DetailsMOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P34884
ChainResidueDetails
FLYS77
GLYS77
HLYS77
ILYS77
JLYS77
KLYS77
LLYS77
MLYS77
NLYS77
OLYS77
PLYS77
QLYS77
RLYS77
ALYS77
BLYS77
CLYS77
DLYS77
ELYS77

221051

PDB entries from 2024-06-12

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