PDB: 51 件ウェブページステータス検索Chemie searchBIRD

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8VLQ	Structure of PmHMGR bound to mevalonate, CoA and NAD 5 minutes after reaction initiation at pH 9 分子名称: (R)-MEVALONATE, (R)-mevaldehyde, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, ... 著者 Purohit, V, Steussy, C.N, Stauffacher, C.V. 登録日 2024-01-12 公開日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.07 Å) 主引用文献 pH-dependent reaction triggering in PmHMGR crystals for time-resolved crystallography. Biophys.J., 123, 2024
8SZ6	PmHMGR bound to mevaldehyde and CoA 分子名称: (3R)-3,5,5-trihydroxy-3-methylpentanoic acid, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, Mevaldyl-Coenzyme A, ... 著者 Purohit, V, Stauffacher, C.V, Steussy, C.N. 登録日 2023-05-27 公開日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 pH-dependent reaction triggering in PmHMGR crystals for time-resolved crystallography. Biophys.J., 123, 2024
8GDN	Structure of PmHMGR bound to mevalonate, CoA and NAD. 分子名称: (R)-MEVALONATE, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, COENZYME A, ... 著者 Purohit, V, Steussy, C.N, Stauffacher, C.V. 登録日 2023-03-06 公開日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.99 Å) 主引用文献 pH-dependent reaction triggering in PmHMGR crystals for time-resolved crystallography. Biophys.J., 123, 2024
8ECG	Complex of HMG1 with pitavastatin 分子名称: 3-hydroxy-3-methylglutaryl-coenzyme A reductase 1, GLYCEROL, Pitavastatin 著者 Haywood, J, Bond, C.S. 登録日 2022-09-01 公開日 2022-09-14 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.13 Å) 主引用文献 A fungal tolerance trait and selective inhibitors proffer HMG-CoA reductase as a herbicide mode-of-action. Nat Commun, 13, 2022
7ULI	Apo HMG-CoA Reductase from Arabidopsis thaliana (HMG1) 分子名称: 3-hydroxy-3-methylglutaryl-coenzyme A reductase 1 著者 Haywood, J, Bond, C.S. 登録日 2022-04-05 公開日 2022-05-18 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 A fungal tolerance trait and selective inhibitors proffer HMG-CoA reductase as a herbicide mode-of-action. Nat Commun, 13, 2022
7N7S	Crystal Structure of Hydroxymethylglutaryl-CoA reductase from Elizabethkingia anophelis NUHP1 分子名称: 1,2-ETHANEDIOL, CITRIC ACID, Hydroxymethylglutaryl-CoA reductase, ... 著者 Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2021-06-11 公開日 2021-06-23 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Crystal Structure of Hydroxymethylglutaryl-CoA reductase from Elizabethkingia anophelis NUHP1 To be published
7M66	Targeting Enterococcus faecalis HMG-CoA reductase with a novel non-statin inhibitor 分子名称: 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... 著者 Bose, S, Steussy, C.N. 登録日 2021-03-25 公開日 2022-09-28 最終更新日 2023-04-12 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Targeting Enterococcus faecalis HMG-CoA reductase with a non-statin inhibitor. Commun Biol, 6, 2023
7M3H	Targeting Enterococcus faecalis HMG-CoA reductase with a novel non-statin inhibitor 分子名称: 5-[(4-butylphenyl)sulfamoyl]-2-hydroxybenzoic acid, CALCIUM ION, Hydroxymethylglutaryl-CoA reductase, ... 著者 Bose, S, Steussy, C.N, Stauffacher, C.V. 登録日 2021-03-18 公開日 2022-09-21 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.27 Å) 主引用文献 Targeting Enterococcus faecalis HMG-CoA reductase with a novel non-statin inhibitor To Be Published
7M1Z	Targeting Enterococcus faecalis HMG-CoA reductase with a novel non-statin inhibitor 分子名称: (R)-MEVALONATE, 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A, ACETATE ION, ... 著者 Bose, S, Steussy, C.N, Stauffacher, C.V. 登録日 2021-03-15 公開日 2022-09-21 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.27 Å) 主引用文献 Targeting Enterococcus faecalis HMG-CoA reductase with a non-statin inhibitor Nat Commun, 2023
6HR8	HMG-CoA reductase from Methanothermococcus thermolithotrophicus in complex with NADPH at 2.9 A resolution 分子名称: DI(HYDROXYETHYL)ETHER, HMG-CoA reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... 著者 Wagner, T, Voegeli, B, Erb, T.J, Shima, S. 登録日 2018-09-26 公開日 2019-02-13 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Crystal structure of archaeal HMG-CoA reductase: insights into structural changes of the C-terminal helix of the class-I enzyme. Febs Lett., 593, 2019
6HR7	HMG-CoA reductase from Methanothermococcus thermolithotrophicus apo form at 2.4 A resolution 分子名称: 2,3-DIHYDROXY-1,4-DITHIOBUTANE, CHLORIDE ION, GLYCEROL, ... 著者 Wagner, T, Voegeli, B, Erb, T.J, Shima, S. 登録日 2018-09-26 公開日 2019-02-13 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Crystal structure of archaeal HMG-CoA reductase: insights into structural changes of the C-terminal helix of the class-I enzyme. Febs Lett., 593, 2019
6EEV	Structure of class II HMG-CoA reductase from Delftia acidovorans with mevalonate bound 分子名称: (R)-MEVALONATE, 3-hydroxy-3-methylglutaryl coenzyme A reductase, GLYCEROL, ... 著者 Ragwan, E.R, Arai, E, Kung, Y. 登録日 2018-08-15 公開日 2018-09-26 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.49 Å) 主引用文献 New Crystallographic Snapshots of Large Domain Movements in Bacterial 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase. Biochemistry, 57, 2018
6EEU	Structure of class II HMG-CoA reductase from Delftia acidovorans 分子名称: 1,2-ETHANEDIOL, 3-hydroxy-3-methylglutaryl coenzyme A reductase, SULFATE ION 著者 Ragwan, E.R, Arai, E, Kung, Y. 登録日 2018-08-15 公開日 2018-09-26 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.93 Å) 主引用文献 New Crystallographic Snapshots of Large Domain Movements in Bacterial 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase. Biochemistry, 57, 2018
6DIO	Structure of class II HMG-CoA reductase from Delftia acidovorans with NAD bound 分子名称: 1,2-ETHANEDIOL, 3-hydroxy-3-methylglutaryl coenzyme A reductase, CITRIC ACID, ... 著者 Ragwan, E.R, Arai, E, Kung, Y. 登録日 2018-05-23 公開日 2018-09-26 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.14 Å) 主引用文献 New Crystallographic Snapshots of Large Domain Movements in Bacterial 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase. Biochemistry, 57, 2018
5WPK	Structure of the class II 3-hydroxy-3-methylglutaryl-CoA reductase from Streptococcus pneumoniae bound to HMG-CoA and in a partially closed conformation 分子名称: 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A, 3-hydroxy-3-methylglutaryl coenzyme A reductase, ... 著者 Miller, B.R, Kung, Y. 登録日 2017-08-04 公開日 2018-04-25 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural Features and Domain Movements Controlling Substrate Binding and Cofactor Specificity in Class II HMG-CoA Reductase. Biochemistry, 57, 2018
5WPJ	Structure of the class II 3-hydroxy-3-methylglutaryl-CoA reductase from Streptococcus pneumoniae bound to NADPH in open conformations 分子名称: 3-hydroxy-3-methylglutaryl coenzyme A reductase, GLYCEROL, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Miller, B.R, Kung, Y. 登録日 2017-08-04 公開日 2018-04-25 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural Features and Domain Movements Controlling Substrate Binding and Cofactor Specificity in Class II HMG-CoA Reductase. Biochemistry, 57, 2018
4I6Y	3-hydroxy-3-methyl (HMG) Coenzyme A Reductase bound to R-Mevalonate 分子名称: (R)-MEVALONATE, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, GLYCEROL, ... 著者 Steussy, C.N, Stauffacher, C.V, Schmidt, T, Burgner II, J.W, Rodwell, V.W, Wrensford, L.V, Critchelow, C.J, Min, J. 登録日 2012-11-30 公開日 2013-07-17 最終更新日 2019-07-17 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 A Novel Role for Coenzyme A during Hydride Transfer in 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase. Biochemistry, 52, 2013
4I6W	3-hydroxy-3-methylglutaryl (HMG) Coenzyme-A reductase complexed with thiomevalonate 分子名称: (3S)-3-hydroxy-3-methyl-5-sulfanylpentanoic acid, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, GLYCEROL, ... 著者 Steussy, C.N, Stauffacher, C.V, Schmidt, T, Burgner II, J.W, Rodwell, V.W, Wrensford, L.V, Critchelow, C.J, Min, J. 登録日 2012-11-30 公開日 2013-07-17 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.66 Å) 主引用文献 A Novel Role for Coenzyme A during Hydride Transfer in 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase. Biochemistry, 52, 2013
4I6A	3-hydroxy-3-methylglutaryl (HMG) Coenzyme A reductase from Pseudomonas mevalonii complexed with HMG-CoA 分子名称: 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, SULFATE ION 著者 Steussy, C.N, Stauffacher, C.V, Schmidt, T, Burgner II, J.W, Rodwell, V.W, Wrensford, L.V, Critchelow, C.J, Min, J. 登録日 2012-11-29 公開日 2013-07-17 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 A Novel Role for Coenzyme A during Hydride Transfer in 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase. Biochemistry, 52, 2013
4I64	3-hydroxy-3-methylglutaryl Coenzyme A reductase from Pseudomonas mevalonii, a high resolution native structure 分子名称: 3-hydroxy-3-methylglutaryl-coenzyme A reductase, SULFATE ION 著者 Steussy, C.N, Stauffacher, C.V, Schmidt, T, Burgner II, J.W, Rodwell, V.W, Wrensford, L.V, Critchelow, C.J, Min, J. 登録日 2012-11-29 公開日 2013-07-17 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 A Novel Role for Coenzyme A during Hydride Transfer in 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase. Biochemistry, 52, 2013
4I56	HMG-CoA reductase from pseudomonas mevalonii complexed with dithio-HMG-coa 分子名称: (3S,5S,9R,21S)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9,21-tetrahydroxy-8,8,21-trimethyl-10,14-dioxo-19-thioxo-2,4,6-trioxa-18-thia-11,15-diaza-3,5-diphosphatricosan-23-oic acid 3,5-dioxide, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, GLYCEROL, ... 著者 Steussy, C.N, Stauffacher, C.V, Schmidt, T, Crichelow, C.J, Rodwell, V.W, Wrensford, L.V, Min, J, Burgner II, J.W. 登録日 2012-11-28 公開日 2013-07-17 最終更新日 2019-07-17 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 A Novel Role for Coenzyme A during Hydride Transfer in 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase. Biochemistry, 52, 2013
4I4B	HMG-CoA Reductase from Pseudomonas mevalonii complexed with NAD and intermediate hemiacetal form of HMG-CoA 分子名称: (3R,5R,9R,19R,21S)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9,21-tetrahydroxy-8,8,21-trimethyl-10,14-dioxo-19-sulfanyl-2,4,6-trioxa-18-thia-11,15-diaza-3,5-diphosphatricosan-23-oic acid 3,5-dioxide, (3S)-3-hydroxy-3-methyl-5-sulfanylpentanoic acid, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, ... 著者 Stauffacher, C.V, Steussy, C.N, Critchelow, C.J, Schmidt, T, Min, J, Wrensford, L.V, Burgner, J.W, Rodwell, V.W. 登録日 2012-11-27 公開日 2013-07-17 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 A Novel Role for Coenzyme A during Hydride Transfer in 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase. Biochemistry, 52, 2013
3QAU	3-Hydroxy-3-MethylGlutaryl-Coenzyme A Reductase from Streptococcus pneumoniae 分子名称: 3-hydroxy-3-methylglutaryl-coenzyme a reductase, GLYCEROL, SODIUM ION, ... 著者 Zhang, L, Feng, L, Zhou, L, Gui, J, Wan, J. 登録日 2011-01-11 公開日 2011-01-26 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 3-Hydroxy-3-MethylGlutaryl-Coenzyme A Reductase from Streptococcus pneumoniae To be Published
3QAE	3-hydroxy-3-methylglutaryl-coenzyme A reductase of Streptococcus pneumoniae 分子名称: 3-hydroxy-3-methylglutaryl-coenzyme a reductase, CITRIC ACID, GLYCEROL, ... 著者 Zhang, L, Feng, L, Zhou, L, Gui, J, Wan, J. 登録日 2011-01-10 公開日 2011-01-26 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 3-hydroxy-3-methylglutaryl-coenzyme A reductase of Streptococcus pneumoniae To be Published
3CDB	Thermodynamic and structure guided design of statin hmg-coa reductase inhibitors 分子名称: (3R,5R)-7-{3-[(4-carbamoylphenyl)sulfamoyl]-4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-pyrrol-1-yl}-3,5-dihydroxyheptanoic acid, 3-hydroxy-3-methylglutaryl-coenzyme A reductase 著者 Pavlovsky, A, Sarver, R.W, Harris, M.S, Finzel, B.C. 登録日 2008-02-26 公開日 2008-06-17 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Thermodynamic and structure guided design of statin based inhibitors of 3-hydroxy-3-methylglutaryl coenzyme a reductase. J.Med.Chem., 51, 2008

 

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