5WPJ

Structure of the class II 3-hydroxy-3-methylglutaryl-CoA reductase from Streptococcus pneumoniae bound to NADPH in open conformations

Summary for 5WPJ

Entry DOI	10.2210/pdb5wpj/pdb
Descriptor	3-hydroxy-3-methylglutaryl coenzyme A reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, GLYCEROL, ... (4 entities in total)
Functional Keywords	3-hydroxy-3-methylglutaryl-coa reductase, hmg-coa, conformational change, oxidoreductase
Biological source	Streptococcus pneumoniae
Total number of polymer chains	4
Total formula weight	186945.08
Authors	Miller, B.R.,Kung, Y. (deposition date: 2017-08-04, release date: 2018-04-25, Last modification date: 2023-10-04)
Primary citation	Miller, B.R.,Kung, Y. Structural Features and Domain Movements Controlling Substrate Binding and Cofactor Specificity in Class II HMG-CoA Reductase. Biochemistry, 57:654-662, 2018 Cited by PubMed: 29224355 DOI: 10.1021/acs.biochem.7b00999 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation