5WPJ
Structure of the class II 3-hydroxy-3-methylglutaryl-CoA reductase from Streptococcus pneumoniae bound to NADPH in open conformations
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D | 3-hydroxy-3-methylglutaryl coenzyme A reductase | polymer | 426 | 46457.8 | 4 | UniProt (A0A0D6J7E8) Pfam (PF00368) UniProt (by SIFTS) (Q8DNS5) In PDB | Streptococcus pneumoniae | HMG-CoA reductase |
| 2 | A | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 1 | Chemie (NDP) | |||
| 3 | B, C, D | GLYCEROL | non-polymer | 92.1 | 4 | Chemie (GOL) | |||
| 4 | water | water | 18.0 | 1653 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 424 (UniProt: A0A0D6J7E8)
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| His 0 | - | expression tag |
| Glu 355 | Val 355 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 185831.3 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1113.8 | |
| All* | Total formula weight | 186945.1 |
