5WPJ

Structure of the class II 3-hydroxy-3-methylglutaryl-CoA reductase from Streptococcus pneumoniae bound to NADPH in open conformations

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004420	molecular_function	hydroxymethylglutaryl-CoA reductase (NADPH) activity
A	0015936	biological_process	coenzyme A metabolic process
A	0016491	molecular_function	oxidoreductase activity
A	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
A	0140643	molecular_function	hydroxymethylglutaryl-CoA reductase (NADH) activity
B	0000166	molecular_function	nucleotide binding
B	0004420	molecular_function	hydroxymethylglutaryl-CoA reductase (NADPH) activity
B	0015936	biological_process	coenzyme A metabolic process
B	0016491	molecular_function	oxidoreductase activity
B	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
B	0140643	molecular_function	hydroxymethylglutaryl-CoA reductase (NADH) activity
C	0000166	molecular_function	nucleotide binding
C	0004420	molecular_function	hydroxymethylglutaryl-CoA reductase (NADPH) activity
C	0015936	biological_process	coenzyme A metabolic process
C	0016491	molecular_function	oxidoreductase activity
C	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
C	0140643	molecular_function	hydroxymethylglutaryl-CoA reductase (NADH) activity
D	0000166	molecular_function	nucleotide binding
D	0004420	molecular_function	hydroxymethylglutaryl-CoA reductase (NADPH) activity
D	0015936	biological_process	coenzyme A metabolic process
D	0016491	molecular_function	oxidoreductase activity
D	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
D	0140643	molecular_function	hydroxymethylglutaryl-CoA reductase (NADH) activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	26
Details	binding site for residue NDP A 500

Chain	Residue
A	SER146
A	ASN184
A	LEU210
A	ASN212
A	ASP279
A	LYS325
A	HOH614
A	HOH642
A	HOH643
A	HOH669
A	HOH682
A	ARG150
A	HOH721
A	HOH760
A	HOH835
A	HOH853
B	GLU81
B	LYS263
B	HOH637
A	THR177
A	GLN178
A	GLU179
A	ALA180
A	MET181
A	GLY182
A	ALA183

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site_id	AC2
Number of Residues	5
Details	binding site for residue GOL B 501

Chain	Residue
A	TYR256
B	HIS158
B	HOH611
B	HOH631
B	HOH712

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site_id	AC3
Number of Residues	7
Details	binding site for residue GOL B 502

Chain	Residue
B	LEU300
B	CYS302
B	GLU315
B	MET316
B	THR317
B	HOH604
B	HOH639

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site_id	AC4
Number of Residues	6
Details	binding site for residue GOL C 501

Chain	Residue
C	HIS158
C	TYR172
C	HIS174
C	HOH632
C	HOH686
D	TYR256

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site_id	AC5
Number of Residues	6
Details	binding site for residue GOL D 501

Chain	Residue
C	TYR256
D	HIS158
D	TYR172
D	HIS174
D	HOH628
D	HOH680

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Functional Information from PROSITE/UniProt

site_id	PS01192
Number of Residues	14
Details	HMG_COA_REDUCTASE_3 Hydroxymethylglutaryl-coenzyme A reductases signature 3. ALvStgIqQGHMkL

Chain	Residue	Details
A	ALA368-LEU381

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