5WPJ
Structure of the class II 3-hydroxy-3-methylglutaryl-CoA reductase from Streptococcus pneumoniae bound to NADPH in open conformations
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004420 | molecular_function | hydroxymethylglutaryl-CoA reductase (NADPH) activity |
| A | 0015936 | biological_process | coenzyme A metabolic process |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0140643 | molecular_function | hydroxymethylglutaryl-CoA reductase (NADH) activity |
| B | 0004420 | molecular_function | hydroxymethylglutaryl-CoA reductase (NADPH) activity |
| B | 0015936 | biological_process | coenzyme A metabolic process |
| B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| B | 0140643 | molecular_function | hydroxymethylglutaryl-CoA reductase (NADH) activity |
| C | 0004420 | molecular_function | hydroxymethylglutaryl-CoA reductase (NADPH) activity |
| C | 0015936 | biological_process | coenzyme A metabolic process |
| C | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| C | 0140643 | molecular_function | hydroxymethylglutaryl-CoA reductase (NADH) activity |
| D | 0004420 | molecular_function | hydroxymethylglutaryl-CoA reductase (NADPH) activity |
| D | 0015936 | biological_process | coenzyme A metabolic process |
| D | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| D | 0140643 | molecular_function | hydroxymethylglutaryl-CoA reductase (NADH) activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 26 |
| Details | binding site for residue NDP A 500 |
| Chain | Residue |
| A | SER146 |
| A | ASN184 |
| A | LEU210 |
| A | ASN212 |
| A | ASP279 |
| A | LYS325 |
| A | HOH614 |
| A | HOH642 |
| A | HOH643 |
| A | HOH669 |
| A | HOH682 |
| A | ARG150 |
| A | HOH721 |
| A | HOH760 |
| A | HOH835 |
| A | HOH853 |
| B | GLU81 |
| B | LYS263 |
| B | HOH637 |
| A | THR177 |
| A | GLN178 |
| A | GLU179 |
| A | ALA180 |
| A | MET181 |
| A | GLY182 |
| A | ALA183 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue GOL B 501 |
| Chain | Residue |
| A | TYR256 |
| B | HIS158 |
| B | HOH611 |
| B | HOH631 |
| B | HOH712 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue GOL B 502 |
| Chain | Residue |
| B | LEU300 |
| B | CYS302 |
| B | GLU315 |
| B | MET316 |
| B | THR317 |
| B | HOH604 |
| B | HOH639 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue GOL C 501 |
| Chain | Residue |
| C | HIS158 |
| C | TYR172 |
| C | HIS174 |
| C | HOH632 |
| C | HOH686 |
| D | TYR256 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue GOL D 501 |
| Chain | Residue |
| C | TYR256 |
| D | HIS158 |
| D | TYR172 |
| D | HIS174 |
| D | HOH628 |
| D | HOH680 |
Functional Information from PROSITE/UniProt
| site_id | PS01192 |
| Number of Residues | 14 |
| Details | HMG_COA_REDUCTASE_3 Hydroxymethylglutaryl-coenzyme A reductases signature 3. ALvStgIqQGHMkL |
| Chain | Residue | Details |
| A | ALA368-LEU381 |
