7M66
Targeting Enterococcus faecalis HMG-CoA reductase with a novel non-statin inhibitor
Summary for 7M66
| Entry DOI | 10.2210/pdb7m66/pdb |
| Related | 7M1Z 7M3H |
| Descriptor | Hydroxymethylglutaryl-CoA reductase, degradative, SULFATE ION, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (7 entities in total) |
| Functional Keywords | antibiotic, bacterial, hmg-coa reductase, antimicrobial protein |
| Biological source | Enterococcus faecalis (Streptococcus faecalis) |
| Total number of polymer chains | 4 |
| Total formula weight | 186876.32 |
| Authors | Bose, S.,Steussy, C.N. (deposition date: 2021-03-25, release date: 2022-09-28, Last modification date: 2023-04-12) |
| Primary citation | Bose, S.,Steussy, C.N.,Lopez-Perez, D.,Schmidt, T.,Kulathunga, S.C.,Seleem, M.N.,Lipton, M.,Mesecar, A.D.,Rodwell, V.W.,Stauffacher, C.V. Targeting Enterococcus faecalis HMG-CoA reductase with a non-statin inhibitor. Commun Biol, 6:360-360, 2023 Cited by PubMed: 37012403DOI: 10.1038/s42003-023-04639-y PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.25 Å) |
Structure validation
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