7M1Z

Targeting Enterococcus faecalis HMG-CoA reductase with a novel non-statin inhibitor

Summary for 7M1Z

• Entry DOI: 10.2210/pdb7m1z/pdb
• Descriptor: Hydroxymethylglutaryl-CoA reductase, degradative, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, GLYCEROL, ... (8 entities in total)
• Functional Keywords: ligands, metabolism, drug target, hmg-coa, mevalonate, prokaryote., antibiotic
• Biological source: Enterococcus faecalis (Streptococcus faecalis)
• Total number of polymer chains: 4
• Total formula weight: 192901.73

Authors

Bose, S.,Steussy, C.N.,Stauffacher, C.V. (deposition date: 2021-03-15, release date: 2022-09-21, Last modification date: 2023-10-25)

• Primary citation: Bose, S.,Steussy, C.N.,Lopez-Perez, D.,Schmidt, T.,Kulathunga, S.C.,Seleem, M.N.,Lipton, M.,Mesecar, A.D.,Rodwell, V.W.,Stauffacher, C.V.; Targeting Enterococcus faecalis HMG-CoA reductase with a non-statin inhibitor; Nat Commun, 2023; DOI: 10.1038/s42003-023-04639-y

Experimental method

X-RAY DIFFRACTION (2.27 Å)