7M1Z
Targeting Enterococcus faecalis HMG-CoA reductase with a novel non-statin inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | acetyl-CoA C-acetyltransferase | polymer | 430 | 46854.4 | 4 | UniProt (A0A4U3MLJ4) Pfam (PF00368) UniProt (by SIFTS) (Q835L3) | Enterococcus faecalis | Acetoacetyl-CoA thiolase |
| 2 | E, EA, R, X (A, D, B, C) | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 4 | Chemie (NAP) | |||
| 3 | F, G, H, S, T... (A, B, C) | GLYCEROL | non-polymer | 92.1 | 7 | Chemie (GOL) | |||
| 4 | AA, BA, FA, GA, I... (C, D, A, B) | CALCIUM ION | non-polymer | 40.1 | 7 | Chemie (CA) | |||
| 5 | CA, DA, K, L, M... (C, A, B) | ACETATE ION | non-polymer | 59.0 | 9 | Chemie (ACT) | |||
| 6 | Q (B) | 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A | non-polymer | 906.6 | 1 | Chemie (HMG) | |||
| 7 | W (C) | (R)-MEVALONATE | non-polymer | 147.1 | 1 | Chemie (MEV) | |||
| 8 | HA, IA, JA, KA (A, B, C, D) | water | water | 18.0 | 340 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 423 (UniProt: A0A4U3MLJ4)
| PDB | External Database | Details |
|---|---|---|
| Leu -6 | - | expression tag |
| Val -5 | - | expression tag |
| Pro -4 | - | expression tag |
| Arg -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
| His 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 187417.7 | |
| Non-Polymers* | Number of molecules | 29 |
| Total formula weight | 5484.0 | |
| All* | Total formula weight | 192901.7 |
