6HR8
HMG-CoA reductase from Methanothermococcus thermolithotrophicus in complex with NADPH at 2.9 A resolution
Summary for 6HR8
Entry DOI | 10.2210/pdb6hr8/pdb |
Descriptor | HMG-CoA reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, SULFATE ION, ... (6 entities in total) |
Functional Keywords | hmg-coa, mevalonate biosynthesis, statins, cholesterol biosynthesis, isoprenoids, nadph, structural rearrangement., oxidoreductase |
Biological source | Methanothermococcus thermolithotrophicus DSM 2095 More |
Total number of polymer chains | 6 |
Total formula weight | 285794.62 |
Authors | Wagner, T.,Voegeli, B.,Erb, T.J.,Shima, S. (deposition date: 2018-09-26, release date: 2019-02-13, Last modification date: 2024-01-24) |
Primary citation | Vogeli, B.,Shima, S.,Erb, T.J.,Wagner, T. Crystal structure of archaeal HMG-CoA reductase: insights into structural changes of the C-terminal helix of the class-I enzyme. Febs Lett., 593:543-553, 2019 Cited by PubMed: 30702149DOI: 10.1002/1873-3468.13331 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
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