6HR8
HMG-CoA reductase from Methanothermococcus thermolithotrophicus in complex with NADPH at 2.9 A resolution
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000166 | molecular_function | nucleotide binding |
A | 0004420 | molecular_function | hydroxymethylglutaryl-CoA reductase (NADPH) activity |
A | 0008299 | biological_process | isoprenoid biosynthetic process |
A | 0015936 | biological_process | coenzyme A metabolic process |
A | 0016126 | biological_process | sterol biosynthetic process |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
B | 0000166 | molecular_function | nucleotide binding |
B | 0004420 | molecular_function | hydroxymethylglutaryl-CoA reductase (NADPH) activity |
B | 0008299 | biological_process | isoprenoid biosynthetic process |
B | 0015936 | biological_process | coenzyme A metabolic process |
B | 0016126 | biological_process | sterol biosynthetic process |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
C | 0000166 | molecular_function | nucleotide binding |
C | 0004420 | molecular_function | hydroxymethylglutaryl-CoA reductase (NADPH) activity |
C | 0008299 | biological_process | isoprenoid biosynthetic process |
C | 0015936 | biological_process | coenzyme A metabolic process |
C | 0016126 | biological_process | sterol biosynthetic process |
C | 0016491 | molecular_function | oxidoreductase activity |
C | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
D | 0000166 | molecular_function | nucleotide binding |
D | 0004420 | molecular_function | hydroxymethylglutaryl-CoA reductase (NADPH) activity |
D | 0008299 | biological_process | isoprenoid biosynthetic process |
D | 0015936 | biological_process | coenzyme A metabolic process |
D | 0016126 | biological_process | sterol biosynthetic process |
D | 0016491 | molecular_function | oxidoreductase activity |
D | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
E | 0000166 | molecular_function | nucleotide binding |
E | 0004420 | molecular_function | hydroxymethylglutaryl-CoA reductase (NADPH) activity |
E | 0008299 | biological_process | isoprenoid biosynthetic process |
E | 0015936 | biological_process | coenzyme A metabolic process |
E | 0016126 | biological_process | sterol biosynthetic process |
E | 0016491 | molecular_function | oxidoreductase activity |
E | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
F | 0000166 | molecular_function | nucleotide binding |
F | 0004420 | molecular_function | hydroxymethylglutaryl-CoA reductase (NADPH) activity |
F | 0008299 | biological_process | isoprenoid biosynthetic process |
F | 0015936 | biological_process | coenzyme A metabolic process |
F | 0016126 | biological_process | sterol biosynthetic process |
F | 0016491 | molecular_function | oxidoreductase activity |
F | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 14 |
Details | binding site for residue NAP A 501 |
Chain | Residue |
A | LYS63 |
A | ASN199 |
A | MET200 |
A | VAL346 |
A | GLY347 |
A | GLY348 |
A | THR166 |
A | ARG167 |
A | HIS168 |
A | THR192 |
A | ASP194 |
A | ALA195 |
A | GLY197 |
A | MET198 |
site_id | AC2 |
Number of Residues | 2 |
Details | binding site for residue SO4 A 502 |
Chain | Residue |
A | VAL125 |
A | LYS191 |
site_id | AC3 |
Number of Residues | 2 |
Details | binding site for residue PEG A 503 |
Chain | Residue |
A | GLU92 |
A | GLY363 |
site_id | AC4 |
Number of Residues | 4 |
Details | binding site for residue PEG A 504 |
Chain | Residue |
A | CYS118 |
A | PHE256 |
A | LYS258 |
A | GLU261 |
site_id | AC5 |
Number of Residues | 12 |
Details | binding site for residue NAP B 501 |
Chain | Residue |
B | THR166 |
B | ARG167 |
B | HIS168 |
B | THR192 |
B | ASP194 |
B | ALA195 |
B | GLY197 |
B | MET198 |
B | ASN199 |
B | MET200 |
B | VAL346 |
B | GLY348 |
site_id | AC6 |
Number of Residues | 2 |
Details | binding site for residue SO4 B 502 |
Chain | Residue |
B | ASN90 |
B | GLU92 |
site_id | AC7 |
Number of Residues | 3 |
Details | binding site for residue SO4 B 503 |
Chain | Residue |
B | LYS137 |
B | ARG182 |
D | THR328 |
site_id | AC8 |
Number of Residues | 1 |
Details | binding site for residue PEG B 505 |
Chain | Residue |
B | LYS191 |
site_id | AC9 |
Number of Residues | 1 |
Details | binding site for residue PEG B 506 |
Chain | Residue |
B | TYR53 |
site_id | AD1 |
Number of Residues | 12 |
Details | binding site for residue NAP C 501 |
Chain | Residue |
C | LYS63 |
C | THR166 |
C | ARG167 |
C | HIS168 |
C | THR192 |
C | ASP194 |
C | ALA195 |
C | GLY197 |
C | MET198 |
C | ASN199 |
C | MET200 |
C | GLY348 |
site_id | AD2 |
Number of Residues | 4 |
Details | binding site for residue SO4 C 502 |
Chain | Residue |
A | THR328 |
A | GLU329 |
C | LYS137 |
C | ARG182 |
site_id | AD3 |
Number of Residues | 3 |
Details | binding site for residue PEG C 504 |
Chain | Residue |
C | CYS118 |
C | PHE256 |
C | GLU261 |
site_id | AD4 |
Number of Residues | 3 |
Details | binding site for residue PEG C 505 |
Chain | Residue |
C | PHE155 |
C | ILE172 |
C | ASP173 |
site_id | AD5 |
Number of Residues | 10 |
Details | binding site for residue NAP D 501 |
Chain | Residue |
D | THR166 |
D | ARG167 |
D | HIS168 |
D | THR192 |
D | ASP194 |
D | ALA195 |
D | GLY197 |
D | MET198 |
D | ASN199 |
D | MET200 |
site_id | AD6 |
Number of Residues | 2 |
Details | binding site for residue PEG D 502 |
Chain | Residue |
D | ASN90 |
D | PHE93 |
site_id | AD7 |
Number of Residues | 2 |
Details | binding site for residue NA D 503 |
Chain | Residue |
D | CYS118 |
D | GLU261 |
site_id | AD8 |
Number of Residues | 1 |
Details | binding site for residue NA D 504 |
Chain | Residue |
D | GLU28 |
site_id | AD9 |
Number of Residues | 11 |
Details | binding site for residue NAP E 501 |
Chain | Residue |
E | THR166 |
E | ARG167 |
E | HIS168 |
E | THR192 |
E | ASP194 |
E | ALA195 |
E | GLY197 |
E | ASN199 |
E | MET200 |
E | GLY347 |
E | GLY348 |
site_id | AE1 |
Number of Residues | 8 |
Details | binding site for residue NAP F 501 |
Chain | Residue |
F | THR166 |
F | HIS168 |
F | THR192 |
F | ASP194 |
F | ALA195 |
F | GLY197 |
F | ASN199 |
F | MET200 |
Functional Information from PROSITE/UniProt
site_id | PS00066 |
Number of Residues | 15 |
Details | HMG_COA_REDUCTASE_1 Hydroxymethylglutaryl-coenzyme A reductases signature 1. RfVYkTGDaMGmNmV |
Chain | Residue | Details |
B | ARG187-VAL201 | |
A | ARG187-VAL201 |
site_id | PS00318 |
Number of Residues | 8 |
Details | HMG_COA_REDUCTASE_2 Hydroxymethylglutaryl-coenzyme A reductases signature 2. VGtVGGGT |
Chain | Residue | Details |
B | VAL343-THR350 | |
A | VAL343-THR350 |