6HR8
HMG-CoA reductase from Methanothermococcus thermolithotrophicus in complex with NADPH at 2.9 A resolution
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004420 | molecular_function | hydroxymethylglutaryl-CoA reductase (NADPH) activity |
| A | 0008299 | biological_process | isoprenoid biosynthetic process |
| A | 0015936 | biological_process | coenzyme A metabolic process |
| A | 0016126 | biological_process | sterol biosynthetic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004420 | molecular_function | hydroxymethylglutaryl-CoA reductase (NADPH) activity |
| B | 0008299 | biological_process | isoprenoid biosynthetic process |
| B | 0015936 | biological_process | coenzyme A metabolic process |
| B | 0016126 | biological_process | sterol biosynthetic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0004420 | molecular_function | hydroxymethylglutaryl-CoA reductase (NADPH) activity |
| C | 0008299 | biological_process | isoprenoid biosynthetic process |
| C | 0015936 | biological_process | coenzyme A metabolic process |
| C | 0016126 | biological_process | sterol biosynthetic process |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0004420 | molecular_function | hydroxymethylglutaryl-CoA reductase (NADPH) activity |
| D | 0008299 | biological_process | isoprenoid biosynthetic process |
| D | 0015936 | biological_process | coenzyme A metabolic process |
| D | 0016126 | biological_process | sterol biosynthetic process |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| E | 0000166 | molecular_function | nucleotide binding |
| E | 0004420 | molecular_function | hydroxymethylglutaryl-CoA reductase (NADPH) activity |
| E | 0008299 | biological_process | isoprenoid biosynthetic process |
| E | 0015936 | biological_process | coenzyme A metabolic process |
| E | 0016126 | biological_process | sterol biosynthetic process |
| E | 0016491 | molecular_function | oxidoreductase activity |
| E | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| F | 0000166 | molecular_function | nucleotide binding |
| F | 0004420 | molecular_function | hydroxymethylglutaryl-CoA reductase (NADPH) activity |
| F | 0008299 | biological_process | isoprenoid biosynthetic process |
| F | 0015936 | biological_process | coenzyme A metabolic process |
| F | 0016126 | biological_process | sterol biosynthetic process |
| F | 0016491 | molecular_function | oxidoreductase activity |
| F | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 14 |
| Details | binding site for residue NAP A 501 |
| Chain | Residue |
| A | LYS63 |
| A | ASN199 |
| A | MET200 |
| A | VAL346 |
| A | GLY347 |
| A | GLY348 |
| A | THR166 |
| A | ARG167 |
| A | HIS168 |
| A | THR192 |
| A | ASP194 |
| A | ALA195 |
| A | GLY197 |
| A | MET198 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 A 502 |
| Chain | Residue |
| A | VAL125 |
| A | LYS191 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | binding site for residue PEG A 503 |
| Chain | Residue |
| A | GLU92 |
| A | GLY363 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue PEG A 504 |
| Chain | Residue |
| A | CYS118 |
| A | PHE256 |
| A | LYS258 |
| A | GLU261 |
| site_id | AC5 |
| Number of Residues | 12 |
| Details | binding site for residue NAP B 501 |
| Chain | Residue |
| B | THR166 |
| B | ARG167 |
| B | HIS168 |
| B | THR192 |
| B | ASP194 |
| B | ALA195 |
| B | GLY197 |
| B | MET198 |
| B | ASN199 |
| B | MET200 |
| B | VAL346 |
| B | GLY348 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 B 502 |
| Chain | Residue |
| B | ASN90 |
| B | GLU92 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 B 503 |
| Chain | Residue |
| B | LYS137 |
| B | ARG182 |
| D | THR328 |
| site_id | AC8 |
| Number of Residues | 1 |
| Details | binding site for residue PEG B 505 |
| Chain | Residue |
| B | LYS191 |
| site_id | AC9 |
| Number of Residues | 1 |
| Details | binding site for residue PEG B 506 |
| Chain | Residue |
| B | TYR53 |
| site_id | AD1 |
| Number of Residues | 12 |
| Details | binding site for residue NAP C 501 |
| Chain | Residue |
| C | LYS63 |
| C | THR166 |
| C | ARG167 |
| C | HIS168 |
| C | THR192 |
| C | ASP194 |
| C | ALA195 |
| C | GLY197 |
| C | MET198 |
| C | ASN199 |
| C | MET200 |
| C | GLY348 |
| site_id | AD2 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 C 502 |
| Chain | Residue |
| A | THR328 |
| A | GLU329 |
| C | LYS137 |
| C | ARG182 |
| site_id | AD3 |
| Number of Residues | 3 |
| Details | binding site for residue PEG C 504 |
| Chain | Residue |
| C | CYS118 |
| C | PHE256 |
| C | GLU261 |
| site_id | AD4 |
| Number of Residues | 3 |
| Details | binding site for residue PEG C 505 |
| Chain | Residue |
| C | PHE155 |
| C | ILE172 |
| C | ASP173 |
| site_id | AD5 |
| Number of Residues | 10 |
| Details | binding site for residue NAP D 501 |
| Chain | Residue |
| D | THR166 |
| D | ARG167 |
| D | HIS168 |
| D | THR192 |
| D | ASP194 |
| D | ALA195 |
| D | GLY197 |
| D | MET198 |
| D | ASN199 |
| D | MET200 |
| site_id | AD6 |
| Number of Residues | 2 |
| Details | binding site for residue PEG D 502 |
| Chain | Residue |
| D | ASN90 |
| D | PHE93 |
| site_id | AD7 |
| Number of Residues | 2 |
| Details | binding site for residue NA D 503 |
| Chain | Residue |
| D | CYS118 |
| D | GLU261 |
| site_id | AD8 |
| Number of Residues | 1 |
| Details | binding site for residue NA D 504 |
| Chain | Residue |
| D | GLU28 |
| site_id | AD9 |
| Number of Residues | 11 |
| Details | binding site for residue NAP E 501 |
| Chain | Residue |
| E | THR166 |
| E | ARG167 |
| E | HIS168 |
| E | THR192 |
| E | ASP194 |
| E | ALA195 |
| E | GLY197 |
| E | ASN199 |
| E | MET200 |
| E | GLY347 |
| E | GLY348 |
| site_id | AE1 |
| Number of Residues | 8 |
| Details | binding site for residue NAP F 501 |
| Chain | Residue |
| F | THR166 |
| F | HIS168 |
| F | THR192 |
| F | ASP194 |
| F | ALA195 |
| F | GLY197 |
| F | ASN199 |
| F | MET200 |
Functional Information from PROSITE/UniProt
| site_id | PS00066 |
| Number of Residues | 15 |
| Details | HMG_COA_REDUCTASE_1 Hydroxymethylglutaryl-coenzyme A reductases signature 1. RfVYkTGDaMGmNmV |
| Chain | Residue | Details |
| A | ARG187-VAL201 | |
| B | ARG187-VAL201 |
| site_id | PS00318 |
| Number of Residues | 8 |
| Details | HMG_COA_REDUCTASE_2 Hydroxymethylglutaryl-coenzyme A reductases signature 2. VGtVGGGT |
| Chain | Residue | Details |
| A | VAL343-THR350 | |
| B | VAL343-THR350 |
