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6HR8

HMG-CoA reductase from Methanothermococcus thermolithotrophicus in complex with NADPH at 2.9 A resolution

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
HMG-CoA reductasepolymer42746653.81Pfam (PF00368)
UniProt (by SIFTS) (A0A4V8GZY0)
Methanothermococcus thermolithotrophicus DSM 2095
2B, C, D, E, F
(B, C, D, E, F)
HMG-CoA reductasepolymer42746637.85Pfam (PF00368)
UniProt (by SIFTS) (A0A4V8GZY0)
Methanothermococcus thermolithotrophicus DSM 2095
3AA, BA, G, L, R...
(E, F, A, B, C...)
NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATEnon-polymer743.46Chemie (NAP)
4H, M, N, S
(A, B, C)
SULFATE IONnon-polymer96.14Chemie (SO4)
5I, J, K, O, P...
(A, B, C, D)
DI(HYDROXYETHYL)ETHERnon-polymer106.110Chemie (PEG)
6Y, Z
(D)
SODIUM IONnon-polymer23.02Chemie (NA)
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains6
Total formula weight279842.8
Non-Polymers*Number of molecules22
Total formula weight5951.9
All*Total formula weight285794.6
*Water molecules are not included.

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PDB entries from 2025-12-10

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