5WPK

Structure of the class II 3-hydroxy-3-methylglutaryl-CoA reductase from Streptococcus pneumoniae bound to HMG-CoA and in a partially closed conformation

Summary for 5WPK

• Entry DOI: 10.2210/pdb5wpk/pdb
• Descriptor: 3-hydroxy-3-methylglutaryl coenzyme A reductase, 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A, GLYCEROL, ... (5 entities in total)
• Functional Keywords: 3-hydroxy-3-methylglutaryl-coa reductase, hmg-coa, conformational change, oxidoreductase
• Biological source: Streptococcus pneumoniae
• Total number of polymer chains: 2
• Total formula weight: 95714.03

Authors

Miller, B.R.,Kung, Y. (deposition date: 2017-08-04, release date: 2018-04-25, Last modification date: 2023-10-04)

• Primary citation: Miller, B.R.,Kung, Y.; Structural Features and Domain Movements Controlling Substrate Binding and Cofactor Specificity in Class II HMG-CoA Reductase.; Biochemistry, 57:654-662, 2018; PubMed: 29224355; DOI: 10.1021/acs.biochem.7b00999

Experimental method

X-RAY DIFFRACTION (2.3 Å)