5WPK
Structure of the class II 3-hydroxy-3-methylglutaryl-CoA reductase from Streptococcus pneumoniae bound to HMG-CoA and in a partially closed conformation
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | 3-hydroxy-3-methylglutaryl coenzyme A reductase | polymer | 426 | 46457.8 | 2 | UniProt (A0A0D6J7E8) Pfam (PF00368) UniProt (by SIFTS) (Q8DNS5) | Streptococcus pneumoniae | HMG-CoA reductase |
| 2 | C, F (A, B) | 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A | non-polymer | 906.6 | 2 | Chemie (HMG) | |||
| 3 | D, G, H (A, B) | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
| 4 | E, I (B) | 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL | non-polymer | 354.4 | 2 | Chemie (PE4) | |||
| 5 | J, K (A, B) | water | water | 18.0 | 417 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 424 (UniProt: A0A0D6J7E8)
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| His 0 | - | expression tag |
| Glu 355 | Val 355 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 92915.6 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 2798.4 | |
| All* | Total formula weight | 95714.0 |
