3CDB

Thermodynamic and structure guided design of statin hmg-coa reductase inhibitors

Summary for 3CDB

Related3CCT 3CCW 3CCZ 3CD0 3CD5 3CD7 3CDA
Descriptor3-hydroxy-3-methylglutaryl-coenzyme A reductase, (3R,5R)-7-{3-[(4-carbamoylphenyl)sulfamoyl]-4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-pyrrol-1-yl}-3,5-dihydroxyheptanoic acid (3 entities in total)
Functional Keywordsoxidoreductase, cholesterol biosynthesis, hmg-coa, nadph, statin, alternative splicing, endoplasmic reticulum, glycoprotein, lipid synthesis, membrane, peroxisome, polymorphism, steroid biosynthesis, transmembrane
Biological sourceHomo sapiens (Human)
Cellular locationEndoplasmic reticulum membrane; Multi-pass membrane protein P04035
Total number of polymer chains4
Total molecular weight192541.04
Authors
Pavlovsky, A.,Sarver, R.W.,Harris, M.S.,Finzel, B.C. (deposition date: 2008-02-26, release date: 2008-06-17, Last modification date: 2017-10-25)
Primary citation
Sarver, R.W.,Bills, E.,Bolton, G.,Bratton, L.D.,Caspers, N.L.,Dunbar, J.B.,Harris, M.S.,Hutchings, R.H.,Kennedy, R.M.,Larsen, S.D.,Pavlovsky, A.,Pfefferkorn, J.A.,Bainbridge, G.
Thermodynamic and structure guided design of statin based inhibitors of 3-hydroxy-3-methylglutaryl coenzyme a reductase.
J.Med.Chem., 51:3804-3813, 2008
PubMed: 18540668 (PDB entries with the same primary citation)
DOI: 10.1021/jm7015057
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.3 Å)
?

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.23820.3%3.4%6.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report