Summary for 3CCT
|Related||3CCW 3CCZ 3CD0 3CD5 3CD7 3CDA 3CDB|
|Descriptor||3-hydroxy-3-methylglutaryl-coenzyme A reductase, (3R,5R)-7-[2-(4-fluorophenyl)-4-[(2-hydroxyphenyl)carbamoyl]-5-(1-methylethyl)-3-phenyl-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoic acid (3 entities in total)|
|Functional Keywords||oxidoreductase, cholesterol biosynthesis, hmg-coa, nadph, statin, alternative splicing, endoplasmic reticulum, glycoprotein, lipid synthesis, membrane, peroxisome, polymorphism, steroid biosynthesis, transmembrane|
|Biological source||Homo sapiens (Human)|
|Cellular location||Endoplasmic reticulum membrane; Multi-pass membrane protein P04035 |
|Total number of polymer chains||4|
|Total molecular weight||192216.76|
Sarver, R.W.,Bills, E.,Bolton, G.,Bratton, L.D.,Caspers, N.L.,Dunbar, J.B.,Harris, M.S.,Hutchings, R.H.,Kennedy, R.M.,Larsen, S.D.,Pavlovsky, A.,Pfefferkorn, J.A.,Bainbridge, G.
Thermodynamic and structure guided design of statin based inhibitors of 3-hydroxy-3-methylglutaryl coenzyme a reductase.
J.Med.Chem., 51:3804-3813, 2008
PubMed: 18540668 (PDB entries with the same primary citation)
Import into Mendeley
X-RAY DIFFRACTION (2.12 Å)