4UA6
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6MZ2
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4UA9
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1M40
| ULTRA HIGH RESOLUTION CRYSTAL STRUCTURE OF TEM-1 | Descriptor: | BETA-LACTAMASE TEM, PHOSPHATE ION, PINACOL[[2-AMINO-ALPHA-(1-CARBOXY-1-METHYLETHOXYIMINO)-4-THIAZOLEACETYL]AMINO]METHANEBORONATE, ... | Authors: | Minasov, G, Wang, X, Shoichet, B.K. | Deposit date: | 2002-07-01 | Release date: | 2002-07-17 | Last modified: | 2021-10-27 | Method: | X-RAY DIFFRACTION (0.85 Å) | Cite: | An ultrahigh resolution structure of TEM-1 beta-lactamase suggests a role for Glu166 as the general base in acylation. J.Am.Chem.Soc., 124, 2002
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5VLE
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4UAA
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2P74
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4UA7
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1N9B
| Ultrahigh resolution structure of a class A beta-lactamase: On the mechanism and specificity of the extended-spectrum SHV-2 enzyme | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, BETA-LACTAMASE SHV-2, ... | Authors: | Nukaga, M, Mayama, K, Hujer, A.M, Bonomo, R.A, Knox, J.R. | Deposit date: | 2002-11-22 | Release date: | 2003-04-08 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (0.9 Å) | Cite: | Ultrahigh resolution structure of a class A beta-lactamase: On the mechanism and specificity of the extended-spectrum SHV-2 enzyme J.Mol.Biol., 328, 2003
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2ZQ7
| Apo structure of Class A beta-lactamase Toho-1 E166A/R274N/R276N triple mutant | Descriptor: | Beta-lactamase Toho-1, SULFATE ION | Authors: | Shimamura, T, Nitanai, Y, Uchiyama, T, Ago, H, Matsuzawa, H, Miyano, M. | Deposit date: | 2008-08-07 | Release date: | 2009-07-28 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (0.94 Å) | Cite: | Improvement of the Crystal Quality by the Surface Mutations on a Beta-Lactamase Toho-1 To be Published
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2ZQA
| Cefotaxime acyl-intermediate structure of class a beta-lacta Toho-1 E166A/R274N/R276N triple mutant | Descriptor: | Beta-lactamase Toho-1, CEFOTAXIME, C3' cleaved, ... | Authors: | Nitanai, Y, Shimamura, T, Uchiyama, T, Ishii, Y, Takehira, M, Yutani, K, Matsuzawa, H, Miyano, M. | Deposit date: | 2008-08-07 | Release date: | 2009-07-28 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (0.95 Å) | Cite: | Structural Basis of Extend Spectrum Beta-Lactamase in Correlation of Enzymatic Kinetics and Thermal Stability of Acyl-Intermediates To be Published
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5F82
| Apo GES-5 C69G mutant | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Beta-lactamase | Authors: | Smith, C.A, Vakulenko, S.B. | Deposit date: | 2015-12-08 | Release date: | 2016-09-07 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (0.96 Å) | Cite: | Role of the Conserved Disulfide Bridge in Class A Carbapenemases. J.Biol.Chem., 291, 2016
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6MU9
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1YLJ
| Atomic resolution structure of CTX-M-9 beta-lactamase | Descriptor: | SULFATE ION, beta-D-fructofuranose-(2-1)-alpha-D-glucopyranose, beta-lactamase CTX-M-9a | Authors: | Chen, Y, Delmas, J, Sirot, J, Shoichet, B, Bonnet, R. | Deposit date: | 2005-01-19 | Release date: | 2005-04-19 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (0.98 Å) | Cite: | Atomic Resolution Structures of CTX-M beta-Lactamases: Extended Spectrum Activities from Increased Mobility and Decreased Stability. J.Mol.Biol., 348, 2005
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6Z7I
| Crystal structure of CTX-M-15 E166Q mutant apoenzyme | Descriptor: | Beta-lactamase, GLYCEROL, SULFATE ION | Authors: | Tooke, C.L, Hinchliffe, P, Spencer, J. | Deposit date: | 2020-05-31 | Release date: | 2021-06-09 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (0.98 Å) | Cite: | Penicillanic Acid Sulfones Inactivate the Extended-Spectrum beta-Lactamase CTX-M-15 through Formation of a Serine-Lysine Cross-Link: an Alternative Mechanism of beta-Lactamase Inhibition. Mbio, 2022
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7TB7
| Crystal structure of D179N KPC-2 beta-lactamase | Descriptor: | CITRIC ACID, Carbapenem-hydrolyzing beta-lactamase KPC | Authors: | van den Akker, F, Alsenani, T. | Deposit date: | 2021-12-21 | Release date: | 2022-03-02 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (0.99 Å) | Cite: | Structural Characterization of the D179N and D179Y Variants of KPC-2 beta-Lactamase: Omega-Loop Destabilization as a Mechanism of Resistance to Ceftazidime-Avibactam. Antimicrob.Agents Chemother., 66, 2022
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6TD0
| Crystal structure of vaborbactam bound to KPC-2 | Descriptor: | Carbapenem-hydrolyzing beta-lactamase KPC, GLYCEROL, SULFATE ION, ... | Authors: | Tooke, C.L, Hinchliffe, P, Spencer, J. | Deposit date: | 2019-11-07 | Release date: | 2020-01-22 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (0.99 Å) | Cite: | Cyclic boronates as versatile scaffolds for KPC-2 beta-lactamase inhibition. Rsc Med Chem, 11, 2020
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6WJM
| The crystal structure beta-lactamase from Desulfarculus baarsii DSM 2075 | Descriptor: | ALANINE, Beta-lactamase, CITRIC ACID | Authors: | Chang, C, Welk, L, Endres, M, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2020-04-14 | Release date: | 2020-04-22 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1 Å) | Cite: | The crystal structure beta-lactamase from Desulfarculus baarsii DSM 2075 To Be Published
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7Q0Z
| Crystal structure of CTX-M-14 | Descriptor: | Beta-lactamase, GLYCEROL, SULFATE ION | Authors: | Werner, N, Perbandt, M, Hinrichs, W, Prester, A, Rohde, H, Aepfelbacher, M, Betzel, C. | Deposit date: | 2021-10-17 | Release date: | 2022-04-13 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1 Å) | Cite: | Structural basis to repurpose boron-based proteasome inhibitors Bortezomib and Ixazomib as beta-lactamase inhibitors. Sci Rep, 12, 2022
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6MZ1
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6V7H
| Structure of CTX-M-14 bound to Vaborbactam at 1.0 A | Descriptor: | 2-[(3~{R},6~{S})-2,2-bis(oxidanyl)-3-(2-thiophen-2-ylethanoylamino)-1-oxa-2-boranuidacyclohex-6-yl]ethanoic acid, Beta-lactamase, PHOSPHATE ION, ... | Authors: | Pemberton, O.A, Chen, Y. | Deposit date: | 2019-12-08 | Release date: | 2020-08-12 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1 Å) | Cite: | Structural Basis and Binding Kinetics of Vaborbactam in Class A beta-Lactamase Inhibition. Antimicrob.Agents Chemother., 64, 2020
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8R7M
| CTX-M14 in complex with boric acid and 1,2-diol boric ester | Descriptor: | BORIC ACID, Beta-lactamase, GLYCEROL, ... | Authors: | Werner, N, Prester, A, Hinrichs, W, Perbandt, M, Betzel, C. | Deposit date: | 2023-11-26 | Release date: | 2024-01-17 | Last modified: | 2024-07-17 | Method: | X-RAY DIFFRACTION (1 Å) | Cite: | Time-resolved crystallography of boric acid binding to the active site serine of the beta-lactamase CTX-M-14 and subsequent 1,2-diol esterification. Commun Chem, 7, 2024
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8EHH
| Crystal structure of the class A extended-spectrum beta-lactamase CTX-M-96 in complex with relebactam at 1.03 Angstrom resolution | Descriptor: | (2S,5R)-1-formyl-N-(piperidin-4-yl)-5-[(sulfooxy)amino]piperidine-2-carboxamide, Beta-lactamase | Authors: | Power, P, Ghiglione, B, Bonomo, R.A, Rodriguez, M.M, Gutkind, G, Klinke, S. | Deposit date: | 2022-09-14 | Release date: | 2023-09-20 | Last modified: | 2024-10-09 | Method: | X-RAY DIFFRACTION (1.03 Å) | Cite: | Crystal structure of the class A extended-spectrum beta-lactamase CTX-M-96 in complex with relebactam at 1.03 Angstrom resolution. Antimicrob.Agents Chemother., 68, 2024
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2ZQ8
| Apo structure of class a beta-lactamase Toho-1 R274N/R276N double mutant | Descriptor: | Beta-lactamase Toho-1, SULFATE ION | Authors: | Shimamura, T, Nitanai, Y, Uchiyama, T, Ago, H, Matsuzawa, H, Miyano, M. | Deposit date: | 2008-08-07 | Release date: | 2009-07-28 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.03 Å) | Cite: | Improvement of crystal quality by surface mutations of beta-lactamase Toho-1 Acta Crystallogr.,Sect.F, 65, 2009
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6QWB
| Crystal structure of KPC-4 complexed with relebactam (16 hour soak) | Descriptor: | (2S,5R)-1-formyl-N-(piperidin-4-yl)-5-[(sulfooxy)amino]piperidine-2-carboxamide, (2~{S})-5-azanylidene-2-(piperidin-4-ylcarbamoyl)piperidine-1-carboxylic acid, Beta-lactamase, ... | Authors: | Tooke, C.L, Hinchliffe, P, Spencer, J. | Deposit date: | 2019-03-05 | Release date: | 2019-08-21 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.04 Å) | Cite: | Molecular Basis of Class A beta-Lactamase Inhibition by Relebactam. Antimicrob.Agents Chemother., 63, 2019
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