4UA9

CTX-M-14 Class A Beta-Lactamase in Complex with a Boronic Acid Acylation Transition State Analog at Sub-Angstrom Resolution

Summary for 4UA9

• Entry DOI: 10.2210/pdb4ua9/pdb
• Related: 4UA6 4UA7 4UAA
• Descriptor: Beta-lactamase CTX-M-14, PINACOL[[2-AMINO-ALPHA-(1-CARBOXY-1-METHYLETHOXYIMINO)-4-THIAZOLEACETYL]AMINO]METHANEBORONATE, PHOSPHATE ION, ... (4 entities in total)
• Functional Keywords: ctx-m-14, class a beta-lactamase, boronic acid, acylation transition state, hydrolase
• Biological source: Escherichia coli
• Total number of polymer chains: 2
• Total formula weight: 57102.14

Authors

Nichols, D.A.,Chen, Y. (deposition date: 2014-08-08, release date: 2015-06-24, Last modification date: 2023-09-27)

• Primary citation: Nichols, D.A.,Hargis, J.C.,Sanishvili, R.,Jaishankar, P.,Defrees, K.,Smith, E.W.,Wang, K.K.,Prati, F.,Renslo, A.R.,Woodcock, H.L.,Chen, Y.; Ligand-Induced Proton Transfer and Low-Barrier Hydrogen Bond Revealed by X-ray Crystallography.; J.Am.Chem.Soc., 137:8086-8095, 2015; PubMed: 26057252; DOI: 10.1021/jacs.5b00749

Experimental method

X-RAY DIFFRACTION (0.84 Å)