6V7H

Structure of CTX-M-14 bound to Vaborbactam at 1.0 A

Summary for 6V7H

• Entry DOI: 10.2210/pdb6v7h/pdb
• Descriptor: Beta-lactamase, Vaborbactam, 2-[(3~{R},6~{S})-2,2-bis(oxidanyl)-3-(2-thiophen-2-ylethanoylamino)-1-oxa-2-boranuidacyclohex-6-yl]ethanoic acid, ... (6 entities in total)
• Functional Keywords: esbl, boronate, beta-lactamase, inhibitor, hydrolase
• Biological source: Escherichia coli
• Total number of polymer chains: 2
• Total formula weight: 57552.69

Authors

Pemberton, O.A.,Chen, Y. (deposition date: 2019-12-08, release date: 2020-08-12, Last modification date: 2023-10-11)

• Primary citation: Pemberton, O.A.,Tsivkovski, R.,Totrov, M.,Lomovskaya, O.,Chen, Y.; Structural Basis and Binding Kinetics of Vaborbactam in Class A beta-Lactamase Inhibition.; Antimicrob.Agents Chemother., 64:-, 2020; PubMed: 32778546; DOI: 10.1128/AAC.00398-20

Experimental method

X-RAY DIFFRACTION (1 Å)