6MZ2

CTX-M-14 Class A Beta-Lactamase in Complex with Avibactam at pH 7.9

Summary for 6MZ2

Entry DOI	10.2210/pdb6mz2/pdb
Descriptor	Beta-lactamase, (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide, PHOSPHATE ION, ... (6 entities in total)
Functional Keywords	beta-lactamase, complex, ultrahigh, avibactam, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor
Biological source	Escherichia coli
Total number of polymer chains	2
Total formula weight	57291.73
Authors	Pemberton, O.A.,Chen, Y. (deposition date: 2018-11-03, release date: 2019-11-20, Last modification date: 2023-10-11)
Primary citation	Pemberton, O.A.,Noor, R.E.,Kumar M V, V.,Sanishvili, R.,Kemp, M.T.,Kearns, F.L.,Woodcock, H.L.,Gelis, I.,Chen, Y. Mechanism of proton transfer in class A beta-lactamase catalysis and inhibition by avibactam. Proc.Natl.Acad.Sci.USA, 117:5818-5825, 2020 Cited by PubMed: 32123084 DOI: 10.1073/pnas.1922203117 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (0.83 Å)

Structure validation