6MZ1
CTX-M-14 Class A Beta-Lactamase in Complex with Avibactam at pH 5.3
Summary for 6MZ1
Entry DOI | 10.2210/pdb6mz1/pdb |
Descriptor | Beta-lactamase, (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide, PHOSPHATE ION, ... (6 entities in total) |
Functional Keywords | beta-lactamase, complex, ultrahigh, avibactam, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor |
Biological source | Escherichia coli |
Total number of polymer chains | 2 |
Total formula weight | 56988.84 |
Authors | Pemberton, O.A.,Chen, Y. (deposition date: 2018-11-03, release date: 2019-11-20, Last modification date: 2023-10-11) |
Primary citation | Pemberton, O.A.,Noor, R.E.,Kumar M V, V.,Sanishvili, R.,Kemp, M.T.,Kearns, F.L.,Woodcock, H.L.,Gelis, I.,Chen, Y. Mechanism of proton transfer in class A beta-lactamase catalysis and inhibition by avibactam. Proc.Natl.Acad.Sci.USA, 117:5818-5825, 2020 Cited by PubMed: 32123084DOI: 10.1073/pnas.1922203117 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1 Å) |
Structure validation
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