7TI1
| Structure of AmpC bound to RPX-7063 at 2.0A | 分子名称: | 1,2-ETHANEDIOL, Beta-lactamase, CHLORIDE ION, ... | 著者 | Clifton, M.C, Abendroth, J, Edwards, T.E, Hecker, S.J. | 登録日 | 2022-01-12 | 公開日 | 2023-01-25 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Broad-spectrum cyclic boronate beta-lactamase inhibitors featuring an intramolecular prodrug for oral bioavailability. Bioorg.Med.Chem., 62, 2022
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8CUQ
| X-ray crystal structure of ADC-33 in complex with sulfonamidoboronic acid 6e | 分子名称: | 3-[(4R)-4-ethyl-5,7,7-trihydroxy-2,2,7-trioxo-6-oxa-2lambda~6~-thia-3-aza-7lambda~5~-phospha-5-boraheptan-1-yl]benzoic acid, Beta-lactamase | 著者 | Fernando, M.C, Wallar, B.J, Powers, R.A. | 登録日 | 2022-05-17 | 公開日 | 2023-04-05 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Sulfonamidoboronic Acids as "Cross-Class" Inhibitors of an Expanded-Spectrum Class C Cephalosporinase, ADC-33, and a Class D Carbapenemase, OXA-24/40: Strategic Compound Design to Combat Resistance in Acinetobacter baumannii . Antibiotics, 12, 2023
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8CUP
| X-ray crystal structure of ADC-33 in complex with sulfonamidoboronic acid 6d | 分子名称: | 3-[(4S)-4-ethyl-5,7,7-trihydroxy-2,2,7-trioxo-6-oxa-2lambda~6~-thia-3-aza-7lambda~5~-phospha-5-boraheptan-1-yl]benzoic acid, Beta-lactamase | 著者 | Fernando, M.C, Wallar, B.J, Powers, R.A. | 登録日 | 2022-05-17 | 公開日 | 2023-04-05 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.54 Å) | 主引用文献 | Sulfonamidoboronic Acids as "Cross-Class" Inhibitors of an Expanded-Spectrum Class C Cephalosporinase, ADC-33, and a Class D Carbapenemase, OXA-24/40: Strategic Compound Design to Combat Resistance in Acinetobacter baumannii . Antibiotics, 12, 2023
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7U1C
| Structure of EstG crystalized with SO4 and Tris | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Beta-lactamase domain-containing protein, SODIUM ION, ... | 著者 | Gabelli, S.B, Chen, Z. | 登録日 | 2022-02-20 | 公開日 | 2023-01-11 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.09 Å) | 主引用文献 | EstG is a novel esterase required for cell envelope integrity in Caulobacter. Curr.Biol., 33, 2023
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7UDA
| Structure of the EstG | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Beta-lactamase domain-containing protein, SODIUM ION | 著者 | Chen, Z, Gabelli, S.B. | 登録日 | 2022-03-18 | 公開日 | 2023-01-11 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.47 Å) | 主引用文献 | EstG is a novel esterase required for cell envelope integrity in Caulobacter. Curr.Biol., 33, 2023
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7U1B
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1PI5
| Structure of N289A mutant of AmpC in complex with SM2, carboxyphenylglycylboronic acid bearing the cephalothin R1 side chain | 分子名称: | (1R)-1-(2-THIENYLACETYLAMINO)-1-(3-CARBOXYPHENYL)METHYLBORONIC ACID, Beta-lactamase, PHOSPHATE ION, ... | 著者 | Roth, T.A, Minasov, G, Focia, P.J, Shoichet, B.K. | 登録日 | 2003-05-29 | 公開日 | 2004-02-24 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (1.49 Å) | 主引用文献 | Thermodynamic cycle analysis and inhibitor design against beta-lactamase. Biochemistry, 42, 2003
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1PI4
| Structure of N289A mutant of AmpC in complex with SM3, a phenylglyclboronic acid bearing the cephalothin R1 side chain | 分子名称: | (1R)-1-(2-THIENYLACETYLAMINO)-1-PHENYLMETHYLBORONIC ACID, Beta-lactamase, PHOSPHATE ION, ... | 著者 | Roth, T.A, Minasov, G, Focia, P.J, Shoichet, B.K. | 登録日 | 2003-05-29 | 公開日 | 2004-02-24 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (1.39 Å) | 主引用文献 | Thermodynamic cycle analysis and inhibitor design against beta-lactamase. Biochemistry, 42, 2003
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1PWD
| Covalent acyl enzyme complex of the Streptomyces R61 DD-peptidase with cephalosporin C | 分子名称: | (2R)-5-(acetyloxymethyl)-2-[(1R)-1-[[(5R)-5-azanyl-6-oxidanyl-6-oxidanylidene-hexanoyl]amino]-2-oxidanylidene-ethyl]-5,6-dihydro-2H-1,3-thiazine-4-carboxylic acid, D-alanyl-D-alanine carboxypeptidase precursor | 著者 | Silvaggi, N.R, Josephine, H.R, Pratt, R.F, Kelly, J.A. | 登録日 | 2003-07-01 | 公開日 | 2004-07-13 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | Crystal structures of complexes between the R61 DD-peptidase and peptidoglycan-mimetic beta-lactams: a non-covalent complex with a "perfect penicillin" J.Mol.Biol., 345, 2005
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1PW1
| Non-Covalent Complex Of Streptomyces R61 DD-Peptidase With A Highly Specific Penicillin | 分子名称: | (2S,5R,6R)-6-{[(6R)-6-(GLYCYLAMINO)-7-OXIDO-7-OXOHEPTANOYL]AMINO}-3,3-DIMETHYL-7-OXO-4-THIA-1-AZABICYCLO[3.2.0]HEPTANE-2-CARBOXYLATE, D-alanyl-D-alanine carboxypeptidase, FORMYL GROUP, ... | 著者 | Silvaggi, N.R, Josephine, H.R, Pratt, R.F, Kelly, J.A. | 登録日 | 2003-06-30 | 公開日 | 2004-07-13 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | Crystal structures of complexes between the R61 DD-peptidase and peptidoglycan-mimetic beta-lactams: a non-covalent complex with a "perfect penicillin" J.Mol.Biol., 345, 2005
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1Q2Q
| Enterobacter cloacae GC1 class C beta-lactamase complexed with penem WAY185229 | 分子名称: | (6,7-DIHYDRO-5H-CYCLOPENTA[D]IMIDAZO[2,1-B]THIAZOL-2-YL]-4,7-DIHYDRO[1,4]THIAZEPINE-3,6-DICARBOXYLIC ACID, GLYCEROL, class C beta-lactamase | 著者 | Nukaga, M, Venkatesan, A.M, Mansour, T.S, Hujer, A, Bonomo, R.A, Knox, J.R. | 登録日 | 2003-07-25 | 公開日 | 2004-09-14 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Structure-activity relationship of 6-methylidene penems bearing tricyclic heterocycles as broad-spectrum beta-lactamase inhibitors: crystallographic structures show unexpected binding of 1,4-thiazepine intermediates J.Med.Chem., 47, 2004
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1PWC
| penicilloyl acyl enzyme complex of the Streptomyces R61 DD-peptidase with penicillin G | 分子名称: | D-alanyl-D-alanine carboxypeptidase, OPEN FORM - PENICILLIN G | 著者 | Silvaggi, N.R, Josephine, H.R, Pratt, R.F, Kelly, J.A. | 登録日 | 2003-07-01 | 公開日 | 2004-07-13 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | 主引用文献 | Crystal structures of complexes between the R61 DD-peptidase and peptidoglycan-mimetic beta-lactams: a non-covalent complex with a "perfect penicillin" J.Mol.Biol., 345, 2005
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1PW8
| Covalent Acyl Enzyme Complex Of The R61 DD-Peptidase with A Highly Specific Cephalosporin | 分子名称: | (6R,7R)-3-[(ACETYLOXY)METHYL]-7-{[(6S)-6-(GLYCYLAMINO)-7-OXIDO-7-OXOHEPTANOYL]AMINO}-8-OXO-5-THIA-1-AZABICYCLO[4.2.0]OCTANE-2-CARBOXYLATE, D-alanyl-D-alanine carboxypeptidase, GLYCEROL | 著者 | Silvaggi, N.R, Josephine, H.R, Pratt, R.F, Kelly, J.A. | 登録日 | 2003-07-01 | 公開日 | 2004-07-13 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Crystal structures of complexes between the R61 DD-peptidase and peptidoglycan-mimetic beta-lactams: a non-covalent complex with a "perfect penicillin" J.Mol.Biol., 345, 2005
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1PWG
| Covalent Penicilloyl Acyl Enzyme Complex Of The Streptomyces R61 DD-Peptidase With A Highly Specific Penicillin | 分子名称: | (2R,4S)-2-[(1R)-1-{[(6S)-6-carboxy-6-(glycylamino)hexanoyl]amino}-2-oxoethyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, D-alanyl-D-alanine carboxypeptidase | 著者 | Silvaggi, N.R, Josephine, H.R, Pratt, R.F, Kelly, J.A. | 登録日 | 2003-07-01 | 公開日 | 2004-07-13 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (1.074 Å) | 主引用文献 | Crystal structures of complexes between the R61 DD-peptidase and peptidoglycan-mimetic beta-lactams: a non-covalent complex with a "perfect penicillin" J.Mol.Biol., 345, 2005
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6DPX
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6DPZ
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6DPT
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6DPY
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1RGY
| Citrobacter freundii GN346 Class C beta-Lactamase Complexed with Transition-State Analog of Cefotaxime | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, beta-lactamase, {[(2E)-2-(2-AMINO-1,3-THIAZOL-4-YL)-2-(METHOXYIMINO)ETHANOYL]AMINO}METHYLPHOSPHONIC ACID | 著者 | Nukaga, M, Kumar, S, Nukaga, K, Pratt, R.F, Knox, J.R. | 登録日 | 2003-11-13 | 公開日 | 2004-04-06 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.52 Å) | 主引用文献 | Hydrolysis of third-generation cephalosporins by class C beta-lactamases. Structures of a transition state analog of cefotoxamine in wild-type and extended spectrum enzymes. J.Biol.Chem., 279, 2004
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1RGZ
| Enterobacter cloacae GC1 Class C beta-Lactamase Complexed with Transition-State Analog of Cefotaxime | 分子名称: | GLYCEROL, class C beta-lactamase, {[(2E)-2-(2-AMINO-1,3-THIAZOL-4-YL)-2-(METHOXYIMINO)ETHANOYL]AMINO}METHYLPHOSPHONIC ACID | 著者 | Nukaga, M, Kumar, S, Nukaga, K, Pratt, R.F, Knox, J.R. | 登録日 | 2003-11-13 | 公開日 | 2004-04-06 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.37 Å) | 主引用文献 | Hydrolysis of third-generation cephalosporins by class C beta-lactamases. Structures of a transition state analog of cefotoxamine in wild-type and extended spectrum enzymes. J.Biol.Chem., 279, 2004
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1SCW
| TOWARD BETTER ANTIBIOTICS: CRYSTAL STRUCTURE OF R61 DD-PEPTIDASE INHIBITED BY A NOVEL MONOCYCLIC PHOSPHATE INHIBITOR | 分子名称: | (2Z)-3-{[OXIDO(OXO)PHOSPHINO]OXY}-2-PHENYLACRYLATE, D-alanyl-D-alanine carboxypeptidase, GLYCEROL | 著者 | Silvaggi, N.R, Kaur, K, Adediran, S.A, Pratt, R.F, Kelly, J.A. | 登録日 | 2004-02-12 | 公開日 | 2004-06-22 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.13 Å) | 主引用文献 | Toward Better Antibiotics: Crystallographic Studies of a Novel Class of DD-Peptidase/beta-Lactamase Inhibitors. Biochemistry, 43, 2004
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1S6R
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1SDE
| Toward Better Antibiotics: Crystal Structure Of D-Ala-D-Ala Peptidase inhibited by a novel bicyclic phosphate inhibitor | 分子名称: | 2-[(DIOXIDOPHOSPHINO)OXY]BENZOATE, D-alanyl-D-alanine carboxypeptidase, GLYCEROL | 著者 | Silvaggi, N.R, Kaur, K, Adediran, S.A, Pratt, R.F, Kelly, J.A. | 登録日 | 2004-02-13 | 公開日 | 2004-10-12 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.15 Å) | 主引用文献 | Toward better antibiotics: crystallographic studies of a novel class of DD-peptidase/beta-lactamase inhibitors Biochemistry, 43, 2004
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6G9T
| CRYSTAL STRUCTURE OF CMY-136 class C BETA-LACTAMASE | 分子名称: | Beta-lactamase, GLYCEROL, ISOPROPYL ALCOHOL, ... | 著者 | Zavala, A, Retailleau, P, Naas, T, Iorga, B. | 登録日 | 2018-04-11 | 公開日 | 2019-02-27 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Genetic, Biochemical, and Structural Characterization of CMY-136 beta-Lactamase, a Peculiar CMY-2 Variant. Acs Infect Dis., 5, 2019
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6FM6
| Crystal structure of the class C beta-lactamase TRU-1 from Aeromonas enteropelogenes | 分子名称: | Beta-lactamase, SULFATE ION, TRIETHYLENE GLYCOL | 著者 | Pozzi, C, De Luca, F, Di Pisa, F, Benvenuti, M, Docquier, J.D, Mangani, S. | 登録日 | 2018-01-30 | 公開日 | 2018-05-30 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.05 Å) | 主引用文献 | Atomic-Resolution Structure of a Class C beta-Lactamase and Its Complex with Avibactam. ChemMedChem, 13, 2018
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