1SCW

TOWARD BETTER ANTIBIOTICS: CRYSTAL STRUCTURE OF R61 DD-PEPTIDASE INHIBITED BY A NOVEL MONOCYCLIC PHOSPHATE INHIBITOR

Summary for 1SCW

• Entry DOI: 10.2210/pdb1scw/pdb
• Related: 1SDE
• Descriptor: D-alanyl-D-alanine carboxypeptidase, (2Z)-3-{[OXIDO(OXO)PHOSPHINO]OXY}-2-PHENYLACRYLATE, GLYCEROL, ... (4 entities in total)
• Functional Keywords: cyclic phosphate, antibiotic, peptidoglycan, penicillin binding protein, hydrolase
• Biological source: Streptomyces sp.
• Cellular location: Secreted: P15555
• Total number of polymer chains: 1
• Total formula weight: 38200.25

Authors

Silvaggi, N.R.,Kaur, K.,Adediran, S.A.,Pratt, R.F.,Kelly, J.A. (deposition date: 2004-02-12, release date: 2004-06-22, Last modification date: 2023-08-23)

• Primary citation: Silvaggi, N.R.,Kaur, K.,Adediran, S.A.,Pratt, R.F.,Kelly, J.A.; Toward Better Antibiotics: Crystallographic Studies of a Novel Class of DD-Peptidase/beta-Lactamase Inhibitors.; Biochemistry, 43:7046-7053, 2004; PubMed: 15170342; DOI: 10.1021/bi049612c

Experimental method

X-RAY DIFFRACTION (1.13 Å)