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1RGZ

Enterobacter cloacae GC1 Class C beta-Lactamase Complexed with Transition-State Analog of Cefotaxime

Summary for 1RGZ
Entry DOI10.2210/pdb1rgz/pdb
Related1GCE
Descriptorclass C beta-lactamase, {[(2E)-2-(2-AMINO-1,3-THIAZOL-4-YL)-2-(METHOXYIMINO)ETHANOYL]AMINO}METHYLPHOSPHONIC ACID, GLYCEROL, ... (4 entities in total)
Functional Keywordshydrolase, cephalosporinase, enzyme inhibition, phosphonate, beta-lactam antibiotics, drug design
Biological sourceEnterobacter cloacae
Cellular locationPeriplasm (By similarity): P05364
Total number of polymer chains1
Total formula weight39986.47
Authors
Nukaga, M.,Kumar, S.,Nukaga, K.,Pratt, R.F.,Knox, J.R. (deposition date: 2003-11-13, release date: 2004-04-06, Last modification date: 2023-08-23)
Primary citationNukaga, M.,Kumar, S.,Nukaga, K.,Pratt, R.F.,Knox, J.R.
Hydrolysis of third-generation cephalosporins by class C beta-lactamases. Structures of a transition state analog of cefotoxamine in wild-type and extended spectrum enzymes.
J.Biol.Chem., 279:9344-9352, 2004
Cited by
PubMed: 14660590
DOI: 10.1074/jbc.M312356200
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.37 Å)
Structure validation

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