1RGZ
Enterobacter cloacae GC1 Class C beta-Lactamase Complexed with Transition-State Analog of Cefotaxime
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE PTX A 400 |
| Chain | Residue |
| A | GLY63 |
| A | THR322 |
| A | GLY323 |
| A | HOH501 |
| A | HOH503 |
| A | HOH504 |
| A | HOH505 |
| A | HOH513 |
| A | HOH797 |
| A | SER64 |
| A | TYR150 |
| A | ASN152 |
| A | ALA223 |
| A | TYR224 |
| A | GLY225 |
| A | GLY320 |
| A | SER321 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL A 410 |
| Chain | Residue |
| A | PRO181 |
| A | LEU182 |
| A | ASN245 |
| A | VAL246 |
| A | ALA247 |
| A | ASP248 |
| A | HOH718 |
| A | HOH855 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE GOL A 411 |
| Chain | Residue |
| A | GLU275 |
| A | GLY289 |
| A | SER290 |
| A | HIS317 |
| A | LYS318 |
| A | THR319 |
| A | HOH527 |
| A | HOH557 |
| A | HOH581 |
| A | HOH616 |
Functional Information from PROSITE/UniProt
| site_id | PS00336 |
| Number of Residues | 8 |
| Details | BETA_LACTAMASE_C Beta-lactamase class-C active site. FELGSISK |
| Chain | Residue | Details |
| A | PHE60-LYS67 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Acyl-ester intermediate"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Binding site: {} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 1xx2 |
| Chain | Residue | Details |
| A | SER64 | |
| A | LYS318 | |
| A | GLU275 | |
| A | TYR150 | |
| A | LYS67 |
| site_id | MCSA1 |
| Number of Residues | 6 |
| Details | M-CSA 257 |
| Chain | Residue | Details |
| A | SER64 | electrostatic stabiliser, hydrogen bond donor |
| A | LYS67 | electrostatic stabiliser, hydrogen bond donor, increase acidity |
| A | TYR150 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| A | GLU275 | electrostatic stabiliser, hydrogen bond acceptor |
| A | LYS318 | electrostatic stabiliser, hydrogen bond donor, increase acidity |
| A | SER321 | electrostatic stabiliser, hydrogen bond donor |
