1Q2Q
Enterobacter cloacae GC1 class C beta-lactamase complexed with penem WAY185229
Summary for 1Q2Q
Entry DOI | 10.2210/pdb1q2q/pdb |
Related | 1ONG 1ONH 1Q2P 1SHV |
Descriptor | class C beta-lactamase, (6,7-DIHYDRO-5H-CYCLOPENTA[D]IMIDAZO[2,1-B]THIAZOL-2-YL]-4,7-DIHYDRO[1,4]THIAZEPINE-3,6-DICARBOXYLIC ACID, GLYCEROL, ... (4 entities in total) |
Functional Keywords | hydrolase, inhibition, beta-lactam antibiotics, drug design |
Biological source | Enterobacter cloacae |
Total number of polymer chains | 1 |
Total formula weight | 39963.57 |
Authors | Nukaga, M.,Venkatesan, A.M.,Mansour, T.S.,Hujer, A.,Bonomo, R.A.,Knox, J.R. (deposition date: 2003-07-25, release date: 2004-09-14, Last modification date: 2023-08-16) |
Primary citation | Venkatesan, A.M.,Gu, Y.,Dos Santos, O.,Abe, T.,Agarwal, A.,Yang, Y.,Petersen, P.J.,Weiss, W.J.,Mansour, T.S.,Nukaga, M.,Hujer, A.,Bonomo, R.A.,Knox, J.R. Structure-activity relationship of 6-methylidene penems bearing tricyclic heterocycles as broad-spectrum beta-lactamase inhibitors: crystallographic structures show unexpected binding of 1,4-thiazepine intermediates J.Med.Chem., 47:6556-6568, 2004 Cited by PubMed: 15588091DOI: 10.1021/jm049680x PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.4 Å) |
Structure validation
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