1RGY

Citrobacter freundii GN346 Class C beta-Lactamase Complexed with Transition-State Analog of Cefotaxime

Summary for 1RGY

Entry DOI	10.2210/pdb1rgy/pdb
Descriptor	beta-lactamase, {[(2E)-2-(2-AMINO-1,3-THIAZOL-4-YL)-2-(METHOXYIMINO)ETHANOYL]AMINO}METHYLPHOSPHONIC ACID, (4S)-2-METHYL-2,4-PENTANEDIOL, ... (4 entities in total)
Functional Keywords	hydrolase, cephalosporinase, enzyme inhibition, phosphonate, beta-lactam antibiotics, drug design
Biological source	Citrobacter freundii
Cellular location	Periplasm (By similarity): P05193
Total number of polymer chains	1
Total formula weight	40246.83
Authors	Nukaga, M.,Kumar, S.,Nukaga, K.,Pratt, R.F.,Knox, J.R. (deposition date: 2003-11-13, release date: 2004-04-06, Last modification date: 2023-08-23)
Primary citation	Nukaga, M.,Kumar, S.,Nukaga, K.,Pratt, R.F.,Knox, J.R. Hydrolysis of third-generation cephalosporins by class C beta-lactamases. Structures of a transition state analog of cefotoxamine in wild-type and extended spectrum enzymes. J.Biol.Chem., 279:9344-9352, 2004 Cited by PubMed: 14660590 DOI: 10.1074/jbc.M312356200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.52 Å)

Structure validation