8CUQ
X-ray crystal structure of ADC-33 in complex with sulfonamidoboronic acid 6e
Summary for 8CUQ
Entry DOI | 10.2210/pdb8cuq/pdb |
Descriptor | Beta-lactamase, 3-[(4R)-4-ethyl-5,7,7-trihydroxy-2,2,7-trioxo-6-oxa-2lambda~6~-thia-3-aza-7lambda~5~-phospha-5-boraheptan-1-yl]benzoic acid (3 entities in total) |
Functional Keywords | cephalasporinase, inhibitor, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor |
Biological source | Acinetobacter baumannii |
Total number of polymer chains | 2 |
Total formula weight | 82391.31 |
Authors | Fernando, M.C.,Wallar, B.J.,Powers, R.A. (deposition date: 2022-05-17, release date: 2023-04-05, Last modification date: 2024-05-01) |
Primary citation | Introvigne, M.L.,Beardsley, T.J.,Fernando, M.C.,Leonard, D.A.,Wallar, B.J.,Rudin, S.D.,Taracila, M.A.,Rather, P.N.,Colquhoun, J.M.,Song, S.,Fini, F.,Hujer, K.M.,Hujer, A.M.,Prati, F.,Powers, R.A.,Bonomo, R.A.,Caselli, E. Sulfonamidoboronic Acids as "Cross-Class" Inhibitors of an Expanded-Spectrum Class C Cephalosporinase, ADC-33, and a Class D Carbapenemase, OXA-24/40: Strategic Compound Design to Combat Resistance in Acinetobacter baumannii . Antibiotics, 12:-, 2023 Cited by PubMed: 37107006DOI: 10.3390/antibiotics12040644 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.55 Å) |
Structure validation
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