PDB: 729 件ウェブページステータス検索Chemie searchBIRD

---

5KA1	Protein Tyrosine Phosphatase 1B Delta helix 7 mutant in complex with TCS401, closed state 分子名称: 2-(OXALYL-AMINO)-4,5,6,7-TETRAHYDRO-THIENO[2,3-C]PYRIDINE-3-CARBOXYLIC ACID, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, ... 著者 Choy, M.S, Peti, W, Page, R. 登録日 2016-06-01 公開日 2017-03-01 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.84 Å) 主引用文献 Conformational Rigidity and Protein Dynamics at Distinct Timescales Regulate PTP1B Activity and Allostery. Mol. Cell, 65, 2017
5KA3	Protein Tyrosine Phosphatase 1B YAYA (Y152A, Y153A) mutant in complex with TCS401, closed state 分子名称: 2-(OXALYL-AMINO)-4,5,6,7-TETRAHYDRO-THIENO[2,3-C]PYRIDINE-3-CARBOXYLIC ACID, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, ... 著者 Choy, M.S, Peti, W, Page, R. 登録日 2016-06-01 公開日 2017-03-08 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.141 Å) 主引用文献 Conformational Rigidity and Protein Dynamics at Distinct Timescales Regulate PTP1B Activity and Allostery. Mol. Cell, 65, 2017
4QBE	The second sphere residue T263 is important for function and activity of PTP1B through modulating WPD loop 分子名称: Tyrosine-protein phosphatase non-receptor type 1 著者 Xiao, P, Wang, X, Wang, H.M, Fu, X.L, Cui, F.A, Yu, X, Bi, W.X. 登録日 2014-05-08 公開日 2014-12-24 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.292 Å) 主引用文献 The second-sphere residue T263 is important for the function and catalytic activity of PTP1B via interaction with the WPD-loop Int.J.Biochem.Cell Biol., 57C, 2014
4QBW	The second sphere residue T263 is important for function and activity of PTP1B through modulating WPD loop 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Tyrosine-protein phosphatase non-receptor type 1 著者 Xiao, P, Wang, X, Wang, H.M, Fu, X.L, Cui, F.A, Yu, X, Bi, W.X, Sun, J.P. 登録日 2014-05-08 公開日 2015-02-11 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.912 Å) 主引用文献 The second-sphere residue T263 is important for the function and catalytic activity of PTP1B via interaction with the WPD-loop Int.J.Biochem.Cell Biol., 57, 2014
4PVG	Crystal structure of protein tyrosine phosphatase Shp2 catalytic domain complex with small molecular compound L88N79 分子名称: 2-[3-({4-[(1,3-benzodioxol-5-ylmethyl)amino]-4-oxobutanoyl}amino)phenyl]-6-hydroxy-3-iodo-1-methyl-1H-indole-5-carboxylic acid, Tyrosine-protein phosphatase non-receptor type 11 著者 Zhang, Z.-Y, Zeng, L, Liu, D, Yu, Z. 登録日 2014-03-17 公開日 2015-04-15 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Crystal structure of protein tyrosine Shp2 catalytic domain complex with compound L88N79 To be Published
4QAP	The second sphere residue T263 is important for function and activity of PTP1B through modulating WPD loop 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Tyrosine-protein phosphatase non-receptor type 1 著者 Xiao, P, Wang, X, Wang, H.M, Fu, X.L, Cui, F.A, Yu, X, Bi, W.X, Sun, J.P. 登録日 2014-05-05 公開日 2015-02-11 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.903 Å) 主引用文献 The second-sphere residue T263 is important for the function and catalytic activity of PTP1B via interaction with the WPD-loop Int.J.Biochem.Cell Biol., 57, 2014
4QAH	The second sphere residue T263 is important for function and activity of PTP1B through modulating WPD loop 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Tyrosine-protein phosphatase non-receptor type 1 著者 Xiao, P, Wang, X, Wang, H.M, Fu, X.L, Cui, F.A, Bi, W.X. 登録日 2014-05-05 公開日 2014-12-24 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.403 Å) 主引用文献 The second-sphere residue T263 is important for the function and catalytic activity of PTP1B via interaction with the WPD-loop Int.J.Biochem.Cell Biol., 57C, 2014
4QUN	Crystal structure of the PTPN3 (PTPH1) catalytic domain C842S mutant 分子名称: GLYCEROL, PHOSPHATE ION, Tyrosine-protein phosphatase non-receptor type 3 著者 Chen, K.E, Meng, T.C, Wang, A.H.J. 登録日 2014-07-11 公開日 2014-12-10 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.86 Å) 主引用文献 Reciprocal allosteric regulation of p38 gamma and PTPN3 involves a PDZ domain-modulated complex formation. Sci.Signal., 7, 2014
4QUM	Crystal structure of PTPN3 (PTPH1) in complex with a dually phosphorylated MAPK12 peptide 分子名称: Mitogen-activated protein kinase 12, Tyrosine-protein phosphatase non-receptor type 3 著者 Chen, K.E, Meng, T.C, Wang, A.H.J. 登録日 2014-07-10 公開日 2014-12-10 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (2.516 Å) 主引用文献 Reciprocal allosteric regulation of p38 gamma and PTPN3 involves a PDZ domain-modulated complex formation. Sci.Signal., 7, 2014
4RDD	Co-crystal structure of SHP2 in complex with a Cefsulodin derivative 分子名称: 1-({(2R)-4-carboxy-2-[(R)-carboxy{[(2R)-2-phenyl-2-sulfoacetyl]amino}methyl]-3,6-dihydro-2H-1,3-thiazin-5-yl}methyl)pyridinium, Tyrosine-protein phosphatase non-receptor type 11 著者 Zhang, Z.Y, Yu, Z.H, He, R, Zhang, R.Y. 登録日 2014-09-18 公開日 2015-07-01 最終更新日 2015-12-16 実験手法 X-RAY DIFFRACTION (1.601 Å) 主引用文献 Exploring the Existing Drug Space for Novel pTyr Mimetic and SHP2 Inhibitors. ACS Med Chem Lett, 6, 2015
4RH5	Crystal structure of PTPN3 (PTPH1) in complex with Eps15 pTyr849 peptide 分子名称: Epidermal growth factor receptor substrate 15, Tyrosine-protein phosphatase non-receptor type 3 著者 Chen, K.-E, Meng, T.C, Wang, A.H.-J. 登録日 2014-10-01 公開日 2015-03-11 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Substrate specificity and plasticity of FERM-containing protein tyrosine phosphatases. Structure, 23, 2015
4RH9	Crystal structure of PTPN3 (PTPH1) H812F, M883G mutant in complex with Eps15 pTyr849 peptide 分子名称: Epidermal growth factor receptor substrate 15, Tyrosine-protein phosphatase non-receptor type 3 著者 Chen, K.-E, Meng, T.C, Wang, A.H.-J. 登録日 2014-10-01 公開日 2015-03-11 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (1.598 Å) 主引用文献 Substrate specificity and plasticity of FERM-containing protein tyrosine phosphatases. Structure, 23, 2015
4RHG	Crystal structure of PTPN3 (PTPH1) D811E, C842S mutant in complex with Eps15 pTyr849 peptide 分子名称: Epidermal growth factor receptor substrate 15, Tyrosine-protein phosphatase non-receptor type 3 著者 Chen, K.-E, Meng, T.C, Wang, A.H.-J. 登録日 2014-10-02 公開日 2015-03-11 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (1.581 Å) 主引用文献 Substrate specificity and plasticity of FERM-containing protein tyrosine phosphatases. Structure, 23, 2015
4RI4	Crystal structure of PTPN3 (PTPH1) Y676I mutant in complex with vanadate 分子名称: Tyrosine-protein phosphatase non-receptor type 3, VANADATE ION 著者 Chen, K.-E, Meng, T.C, Wang, A.H.-J. 登録日 2014-10-05 公開日 2015-03-11 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.596 Å) 主引用文献 Substrate specificity and plasticity of FERM-containing protein tyrosine phosphatases. Structure, 23, 2015
4RI5	Crystal structure of PTPN3 (PTPH1) D811E mutant in complex with metavanadate 分子名称: GLYCEROL, Tyrosine-protein phosphatase non-receptor type 3, oxido(dioxo)vanadium 著者 Chen, K.-E, Meng, T.C, Wang, A.H.-J. 登録日 2014-10-05 公開日 2015-03-11 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.26 Å) 主引用文献 Substrate specificity and plasticity of FERM-containing protein tyrosine phosphatases. Structure, 23, 2015
4S0G	Crystal structure of PTPN3 (PTPH1) in complex with Eps15 pTyr849 P850V peptide 分子名称: Peptide from Epidermal growth factor receptor substrate 15, Tyrosine-protein phosphatase non-receptor type 3 著者 Chen, K.-E, Meng, T.C, Wang, A.H.-J. 登録日 2014-12-31 公開日 2015-03-11 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (1.723 Å) 主引用文献 Substrate specificity and plasticity of FERM-containing protein tyrosine phosphatases. Structure, 23, 2015
1WCH	Crystal structure of PTPL1 human tyrosine phosphatase mutated in colorectal cancer - evidence for a second phosphotyrosine substrate recognition pocket 分子名称: PHOSPHATE ION, PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 13 著者 Villa, F, Deak, M, Bloomberg, G.B, Alessi, D.R, Van Aalten, D.M.F. 登録日 2004-11-16 公開日 2004-12-14 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Crystal Structure of Ptpl1/Fap-1 Human Tyrosine Phosphatase Mutated in Colorectal Cancer: Eveidence for a Second Phosphotyrosine Substrate Recognition Pocket J.Biol.Chem., 280, 2005
1XBO	PTP1B complexed with Isoxazole Carboxylic Acid 分子名称: 5-(3-{3-[3-HYDROXY-2-(METHOXYCARBONYL)PHENOXY]PROPENYL}PHENYL)-4-(HYDROXYMETHYL)ISOXAZOLE-3-CARBOXYLIC ACID, Protein-tyrosine phosphatase, non-receptor type 1 著者 Zhao, H, Liu, G, Xin, Z, Serby, M, Pei, Z, Szczepankiewicz, B.G, Hajduk, P.J, Abad-Zapatero, C, Hutchins, C.W, Lubben, T.H, Ballaron, S.J, Hassach, D.L, Kaszubska, W, Rondinone, C.M, Trevillyan, J.M, Jirousek, M.R. 登録日 2004-08-31 公開日 2004-10-19 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Isoxazole carboxylic acids as protein tyrosine phosphatase 1B (PTP1B) inhibitors. Bioorg.Med.Chem.Lett., 14, 2004
1XXP	Yersinia YopH (residues 163-468) C403S binds phosphotyrosyl peptide at two sites 分子名称: Hexapeptide ASP-ALA-ASP-GLU-PTR-CLE, Protein-tyrosine phosphatase yopH 著者 Ivanov, M.I, Stuckey, J.A, Schubert, H.L, Saper, M.A, Bliska, J.B. 登録日 2004-11-07 公開日 2005-03-22 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Two substrate-targeting sites in the Yersinia protein tyrosine phosphatase co-operate to promote bacterial virulence Mol.Microbiol., 55, 2005
1XXV	Yersinia YopH (residues 163-468) binds phosphonodifluoromethyl-Phe containing hexapeptide at two sites 分子名称: Epidermal growth factor receptor derived peptide, Protein-tyrosine phosphatase yopH 著者 Ivanov, M.I, Stuckey, J.A, Schubert, H.L, Saper, M.A, Bliska, J.B. 登録日 2004-11-08 公開日 2005-03-22 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Two substrate-targeting sites in the Yersinia protein tyrosine phosphatase co-operate to promote bacterial virulence Mol.Microbiol., 55, 2005
1YGU	Crystal structure of the tandem phosphatase domains of RPTP CD45 with a pTyr peptide 分子名称: Leukocyte common antigen, Polyoma Middle T antigen 著者 Nam, H, Poy, F, Saito, H, Frederick, C.A. 登録日 2005-01-05 公開日 2005-02-22 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structural basis for the function and regulation of the receptor protein tyrosine phosphatase CD45. J.Exp.Med., 201, 2005
1YGR	Crystal structure of the tandem phosphatase domain of RPTP CD45 分子名称: CD45 Protein Tyrosine Phosphatase, T-cell Receptor CD3 zeta ITAM-1 著者 Nam, H.J, Poy, F, Saito, H, Frederick, C.A. 登録日 2005-01-05 公開日 2005-02-22 最終更新日 2021-10-20 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structural basis for the function and regulation of the receptor protein tyrosine phosphatase CD45. J.Exp.Med., 201, 2005
1YTW	YERSINIA PTPASE COMPLEXED WITH TUNGSTATE 分子名称: SULFATE ION, TUNGSTATE(VI)ION, YERSINIA PROTEIN TYROSINE PHOSPHATASE 著者 Fauman, E.B, Schubert, H.L, Saper, M.A. 登録日 1996-05-01 公開日 1996-11-08 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 The X-ray crystal structures of Yersinia tyrosine phosphatase with bound tungstate and nitrate. Mechanistic implications. J.Biol.Chem., 271, 1996
1YTN	HYDROLASE 分子名称: NITRATE ION, YERSINIA PROTEIN TYROSINE PHOSPHATASE 著者 Yuvaniyama, C, Fauman, E.B, Saper, M.A. 登録日 1996-05-01 公開日 1996-11-08 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 The X-ray crystal structures of Yersinia tyrosine phosphatase with bound tungstate and nitrate. Mechanistic implications. J.Biol.Chem., 271, 1996
1YFO	RECEPTOR PROTEIN TYROSINE PHOSPHATASE ALPHA, DOMAIN 1 FROM MOUSE 分子名称: RECEPTOR PROTEIN TYROSINE PHOSPHATASE ALPHA 著者 Bilwes, A.M, Noel, J.P. 登録日 1996-12-11 公開日 1997-04-01 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Structural basis for inhibition of receptor protein-tyrosine phosphatase-alpha by dimerization. Nature, 382, 1996

<3456789101112131415161718>