1YGU

Crystal structure of the tandem phosphatase domains of RPTP CD45 with a pTyr peptide

Summary for 1YGU

Related1YGR
DescriptorLeukocyte common antigen, Polyoma Middle T antigen (2 entities in total)
Functional Keywordscd45, protein tyrosine phosphatase, phosphotyrosine, polyoma middle t antigen, rptp, hydrolase
Biological sourceHomo sapiens (human)
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Cellular locationMembrane; Single-pass type I membrane protein P08575
Host membrane; Single-pass membrane protein (Potential) P03077
Total number of polymer chains4
Total molecular weight144094.18
Authors
Nam, H.,Poy, F.,Saito, H.,Frederick, C.A. (deposition date: 2005-01-05, release date: 2005-02-22, Last modification date: 2011-07-13)
Primary citation
Nam, H.J.,Poy, F.,Saito, H.,Frederick, C.A.
Structural basis for the function and regulation of the receptor protein tyrosine phosphatase CD45.
J.Exp.Med., 201:441-452, 2005
PubMed: 15684325 (PDB entries with the same primary citation)
DOI: 10.1084/jem.20041890
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.9 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliers46 5.1% 11.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
171588
PDB entries from 2020-11-25