Crystal structure of the tandem phosphatase domain of RPTP CD45

Summary for 1YGR

DescriptorCD45 Protein Tyrosine Phosphatase, T-cell Receptor CD3 zeta ITAM-1 (2 entities in total)
Functional Keywordsprotein tyrosine phosphatase, rptp, cd45, lca, lymphocyte activation, cd3 zeta, itam, hydrolase
Biological sourceHomo sapiens (human)
Cellular locationMembrane ; Single-pass type I membrane protein  P08575 P20963
Total number of polymer chains4
Total molecular weight144782.87
Nam, H.J.,Poy, F.,Saito, H.,Frederick, C.A. (deposition date: 2005-01-05, release date: 2005-02-22, Last modification date: 2018-04-18)
Primary citation
Nam, H.J.,Poy, F.,Saito, H.,Frederick, C.A.
Structural basis for the function and regulation of the receptor protein tyrosine phosphatase CD45.
J.Exp.Med., 201:441-452, 2005
PubMed: 15684325 (PDB entries with the same primary citation)
DOI: 10.1084/jem.20041890
MImport into Mendeley
Experimental method

Structure validation

ClashscoreRamachandran outliersSidechain outliers44 5.8% 11.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-11-25