7STH
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7STI
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7STJ
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7STK
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7QAC
| The T2 structure of polycrystalline cubic human insulin | Descriptor: | Insulin A chain, Insulin B chain | Authors: | Karavassili, F, Triandafillidis, D.P, Valmas, A, Spiliopoulou, M, Fili, S, Kontou, P, Bowler, M.W, Von Dreele, R.B, Fitch, A, Margiolaki, I. | Deposit date: | 2021-11-16 | Release date: | 2023-06-21 | Last modified: | 2024-02-07 | Method: | POWDER DIFFRACTION (2.29 Å) | Cite: | The T 2 structure of polycrystalline cubic human insulin. Acta Crystallogr D Struct Biol, 79, 2023
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7QGF
| Cubic Insulin SAD phasing at 14.2 keV | Descriptor: | Insulin A chain, Insulin B chain | Authors: | Nanao, M.H, Basu, S. | Deposit date: | 2021-12-08 | Release date: | 2022-06-01 | Method: | X-RAY DIFFRACTION (1.203 Å) | Cite: | ID23-2: an automated and high-performance microfocus beamline for macromolecular crystallography at the ESRF. J.Synchrotron Radiat., 29, 2022
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7QID
| tentative model of the human insulin receptor ectodomain bound by three insulin | Descriptor: | Insulin, Insulin receptor, Isoform Short of Insulin receptor | Authors: | Gutman, T, Schaefer, I.B, Poojari, C.S, Vattulainen, I, Strauss, M, Coskun, U. | Deposit date: | 2021-12-14 | Release date: | 2022-02-02 | Method: | ELECTRON MICROSCOPY (5 Å) | Cite: | Cryo-EM structure of the complete and ligand-saturated insulin receptor ectodomain J Cell Biol, 219, 2020
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7WRQ
| Structure of Human IGF1/IGFBP3/ALS Ternary Complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin-like growth factor-binding protein 3, Insulin-like growth factor-binding protein complex acid labile subunit, ... | Authors: | Kim, H, Fu, Y, Kim, H.M. | Deposit date: | 2022-01-27 | Release date: | 2022-08-10 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structural basis for assembly and disassembly of the IGF/IGFBP/ALS ternary complex Nat Commun, 13, 2022
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7U6E
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7Z5Q
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7Z5L
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7YRR
| Cryo-EM structure of IGF1R with two IGF1 complex | Descriptor: | Insulin-like growth factor 1 receptor, Isoform 3 of Insulin-like growth factor I | Authors: | Xi, Z, Cang, W. | Deposit date: | 2022-08-10 | Release date: | 2023-08-16 | Method: | ELECTRON MICROSCOPY (4.3 Å) | Cite: | Cryo-EM structure of IGF1R with two IGF1 complex at 4.3 angstroms resolution To Be Published
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8GSG
| T3R3 form of Human insulin with single Zn | Descriptor: | CHLORIDE ION, Insulin A chain, Insulin B chain, ... | Authors: | Zhu, Z.L. | Deposit date: | 2022-09-06 | Release date: | 2023-03-15 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | T3R3 insulin with single Zn To Be Published
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8EYR
| Cryo-EM structure of two IGF1 bound full-length mouse IGF1R mutant (four glycine residues inserted in the alpha-CT; IGF1R-P674G4): symmetric conformation | Descriptor: | Insulin-like growth factor 1 receptor, Insulin-like growth factor I | Authors: | Li, J, Wu, J.Y, Hall, C, Bai, X.C, Choi, E. | Deposit date: | 2022-10-28 | Release date: | 2022-11-09 | Last modified: | 2022-12-07 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Molecular basis for the role of disulfide-linked alpha CTs in the activation of insulin-like growth factor 1 receptor and insulin receptor. Elife, 11, 2022
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8EYX
| Cryo-EM structure of 4 insulins bound full-length mouse IR mutant with physically decoupled alpha CTs (C684S/C685S/C687S; denoted as IR-3CS) Asymmetric conformation 1 | Descriptor: | Insulin, Insulin receptor | Authors: | Li, J, Wu, J.Y, Hall, C, Bai, X.C, Choi, E. | Deposit date: | 2022-10-29 | Release date: | 2022-11-09 | Last modified: | 2022-12-07 | Method: | ELECTRON MICROSCOPY (4.5 Å) | Cite: | Molecular basis for the role of disulfide-linked alpha CTs in the activation of insulin-like growth factor 1 receptor and insulin receptor. Elife, 11, 2022
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8EYY
| Cryo-EM structure of 4 insulins bound full-length mouse IR mutant with physically decoupled alpha CTs (C684S/C685S/C687S, denoted as IR-3CS) Asymmetric conformation 2 | Descriptor: | Insulin, Insulin receptor | Authors: | Li, J, Wu, J.Y, Hall, C, Bai, X.C, Choi, E. | Deposit date: | 2022-10-29 | Release date: | 2022-11-09 | Last modified: | 2022-12-07 | Method: | ELECTRON MICROSCOPY (4.9 Å) | Cite: | Molecular basis for the role of disulfide-linked alpha CTs in the activation of insulin-like growth factor 1 receptor and insulin receptor. Elife, 11, 2022
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8EZ0
| Cryo-EM structure of 4 insulins bound full-length mouse IR mutant with physically decoupled alpha CTs (C684S/C685S/C687S; denoted as IR-3CS) Symmetric conformation | Descriptor: | Insulin, Insulin receptor | Authors: | Li, J, Wu, J.Y, Hall, C, Bai, X.C, Choi, E. | Deposit date: | 2022-10-29 | Release date: | 2022-11-09 | Last modified: | 2023-08-30 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Molecular basis for the role of disulfide-linked alpha CTs in the activation of insulin-like growth factor 1 receptor and insulin receptor. Elife, 11, 2022
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8HGZ
| Crystal structure of insulin | Descriptor: | CHLORIDE ION, Insulin A chain, Insulin B chain, ... | Authors: | DeMirci, H, Ayan, E. | Deposit date: | 2022-11-16 | Release date: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Comparative Study of High-Resolution LysB29(N epsilon-myristoyl) des(B30) Insulin Structures Display Novel Dynamic Causal Interrelations in Monomeric-Dimeric Motions Crystals, 13, 2023
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8HSK
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8HSF
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8CLS
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8IPZ
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8ONK
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8ONI
| Human insulin in complex with the analytical antibody S1 Fab | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of analytical antibody S1 Fab, Insulin A chain, ... | Authors: | Johansson, E. | Deposit date: | 2023-04-03 | Release date: | 2024-04-10 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Macromolecular structure of insulin and IgE clonality impacts IgE-mediated activation of sensitized basophils To Be Published
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8SBD
| Cryo-EM structure of insulin amyloid-like fibril that is composed of two antiparallel protofilaments | Descriptor: | Insulin A chain, Insulin B chain | Authors: | Wang, L.W, Hall, C, Uchikawa, E, Chen, D.L, Choi, E, Zhang, X.W, Bai, X.C. | Deposit date: | 2023-04-03 | Release date: | 2023-08-30 | Last modified: | 2023-09-27 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structural basis of insulin fibrillation. Sci Adv, 9, 2023
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