PDB: 435 件ウェブページステータス検索Chemie searchBIRD

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6S34	Zinc free, dimeric human insulin determined to 1.35 Angstrom resolution 分子名称: 1,2-ETHANEDIOL, Insulin A chain, Insulin B chain 著者 Johansson, E. 登録日 2019-06-24 公開日 2019-07-03 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.35 Å) 主引用文献 Zinc free, dimeric human insulin determined to 1.35 Angstrom resolution Not Published
6S4J	Crystal structure of zinc free A14E, B25H, B29K(N(eps)-[2-(2-[2-(2-[2-(Octadecandioyl-gamma-Glu)amino]ethoxy)ethoxy]acetylamino)ethoxy]ethoxy)acetyl]), desB27, desB30 human insulin 分子名称: IMIDAZOLE, Insulin, KUT [2-(2-[2-(2-[2-(Octadecandioyl-gamma-Glu)amino]ethoxy)ethoxy]acetylamino)ethoxy]ethoxy)acetyl] 著者 Johansson, E. 登録日 2019-06-28 公開日 2020-07-15 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Molecular engineering of safe and efficacious oral basal insulin. Nat Commun, 11, 2020
6S4I	Crystal structure of zinc free A14E, B25H, B29K(N(eps)-[2-(2-[2-(2-[2-(Octadecandioyl-gamma-Glu)amino]ethoxy)ethoxy]acetylamino)ethoxy]ethoxy)acetyl]), desB30 human insulin 分子名称: Insulin, NITRATE ION 著者 Johansson, E. 登録日 2019-06-28 公開日 2020-07-15 最終更新日 2020-08-12 実験手法 X-RAY DIFFRACTION (1.511 Å) 主引用文献 Molecular engineering of safe and efficacious oral basal insulin. Nat Commun, 11, 2020
6KH8	Solution structure of Zn free Bovine Pancreatic Insulin in 20% acetic acid-d4 (pH 1.9) 分子名称: Insulin A Chain, Insulin B chain 著者 Bhunia, A, Ratha, B.N, Kar, R.K, Brender, J.R. 登録日 2019-07-14 公開日 2020-10-07 最終更新日 2020-11-18 実験手法 SOLUTION NMR 主引用文献 High-resolution structure of a partially folded insulin aggregation intermediate. Proteins, 88, 2020
6KH9	Solution structure of bovine insulin amyloid intermediate-1 分子名称: Insulin A chain, Insulin B chain 著者 Ratha, B.N, Kar, R.K, Brender, J.B, Bhunia, A. 登録日 2019-07-14 公開日 2020-08-12 最終更新日 2020-11-18 実験手法 SOLUTION NMR 主引用文献 High-resolution structure of a partially folded insulin aggregation intermediate. Proteins, 88, 2020
6KHA	Solution structure of bovine insulin amyloid intermediate-2 分子名称: Insulin A chain, Insulin B chain 著者 Ratha, B.N, Kar, R.K, Brender, J.B, Bhunia, A. 登録日 2019-07-14 公開日 2020-08-12 最終更新日 2020-11-18 実験手法 SOLUTION NMR 主引用文献 High-resolution structure of a partially folded insulin aggregation intermediate. Proteins, 88, 2020
6PXV	Cryo-EM structure of full-length insulin receptor bound to 4 insulin. 3D refinement was focused on the extracellular region. 分子名称: Insulin, Insulin receptor 著者 Uchikawa, E, Choi, E, Shang, G.J, Yu, H.T, Bai, X.C. 登録日 2019-07-27 公開日 2019-09-04 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Activation mechanism of the insulin receptor revealed by cryo-EM structure of the fully liganded receptor-ligand complex. Elife, 8, 2019
6PXW	Cryo-EM structure of full-length insulin receptor bound to 4 insulin. 3D refinement was focused on the top part of the receptor complex. 分子名称: Insulin, Insulin receptor 著者 Uchikawa, E, Choi, E, Shang, G.J, Yu, H.T, Bai, X.C. 登録日 2019-07-28 公開日 2019-09-04 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Activation mechanism of the insulin receptor revealed by cryo-EM structure of the fully liganded receptor-ligand complex. Elife, 8, 2019
6PYH	Cryo-EM structure of full-length IGF1R-IGF1 complex. Only the extracellular region of the complex is resolved. 分子名称: Insulin-like growth factor 1 receptor, Insulin-like growth factor I 著者 Li, J, Choi, E, Yu, H.T, Bai, X.C. 登録日 2019-07-29 公開日 2019-10-23 実験手法 ELECTRON MICROSCOPY (4.3 Å) 主引用文献 Structural basis of the activation of type 1 insulin-like growth factor receptor. Nat Commun, 10, 2019
6TYH	Four-Disulfide Insulin Analog A22/B22 分子名称: ACETONE, CHLORIDE ION, GLYCEROL, ... 著者 Blakely, A.D, Xiong, X. 登録日 2019-08-08 公開日 2019-11-13 最終更新日 2020-03-11 実験手法 X-RAY DIFFRACTION (1.600019 Å) 主引用文献 Novel four-disulfide insulin analog with high aggregation stability and potency. Chem Sci, 11, 2020
6U46	Solution Structure of a Heat-Resistant Long-Acting Insulin Analog 分子名称: Insulin 著者 Yang, Y, Weiss, M.A. 登録日 2019-08-23 公開日 2020-08-26 最終更新日 2023-06-14 実験手法 SOLUTION NMR 主引用文献 Solution Structure of a Heat-Resistant Long-Acting Insulin Analog To Be Published
6SOF	human insulin receptor ectodomain bound by 4 insulin 分子名称: Insulin, Insulin receptor 著者 Gutmann, T, Schaefer, I.B, Poojari, C.S, Vattulainen, I, Strauss, M, Coskun, U. 登録日 2019-08-29 公開日 2019-11-13 最終更新日 2020-05-27 実験手法 ELECTRON MICROSCOPY (4.3 Å) 主引用文献 Cryo-EM structure of the complete and ligand-saturated insulin receptor ectodomain. J.Cell Biol., 219, 2020
6UM2	Structure of M-6-P/IGFII Receptor and IGFII complex 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Cation-independent mannose-6-phosphate receptor, Insulin-like growth factor II 著者 Wang, R, Qi, X, Li, X. 登録日 2019-10-08 公開日 2020-02-26 最終更新日 2020-07-29 実験手法 ELECTRON MICROSCOPY (4.32 Å) 主引用文献 Marked structural rearrangement of mannose 6-phosphate/IGF2 receptor at different pH environments Sci Adv, 6, 2020
6TC2	Monoclinic human insulin in complex with p-coumaric acid 分子名称: 4'-HYDROXYCINNAMIC ACID, Insulin, PHOSPHATE ION, ... 著者 Triandafillidis, D.-P, Parthenios, N, Spiliopoulou, M, Valmas, A, Kosinas, C, Gozzo, F, Reinle-Schmitt, M, Beckers, D, Degen, T, Pop, M, Fitch, A, Wollenhaupt, J, Weiss, M.S, Karavassili, F, Margiolaki, I. 登録日 2019-11-04 公開日 2020-11-11 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.36 Å) 主引用文献 Insulin polymorphism induced by two polyphenols: new crystal forms and advances in macromolecular powder diffraction. Acta Crystallogr D Struct Biol, 76, 2020
6VEP	Human insulin in complex with the human insulin microreceptor in turn in complex with Fv 83-7 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Lawrence, M.C, Menting, J.G.T. 登録日 2020-01-02 公開日 2020-06-03 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 A structurally minimized yet fully active insulin based on cone-snail venom insulin principles. Nat.Struct.Mol.Biol., 27, 2020
6VWI	Head region of the closed conformation of the human type 1 insulin-like growth factor receptor ectodomain in complex with human insulin-like growth factor II. 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin-like growth factor II, Leucine-zippered human type 1 insulin-like growth factor receptor ectodomain 著者 Xu, Y, Kirk, N.S, Lawrence, M.C, Croll, T.I. 登録日 2020-02-19 公開日 2020-05-13 最終更新日 2020-07-29 実験手法 ELECTRON MICROSCOPY (3.7 Å) 主引用文献 How IGF-II Binds to the Human Type 1 Insulin-like Growth Factor Receptor. Structure, 28, 2020
6VWG	Head region of the open conformation of the human type 1 insulin-like growth factor receptor ectodomain in complex with human insulin-like growth factor II. 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin-like growth factor II, Leucine-zippered human type 1 insulin-like growth factor receptor ectodomain 著者 Xu, Y, Kirk, N.S, Lawrence, M.C, Croll, T.I. 登録日 2020-02-19 公開日 2020-05-13 最終更新日 2020-07-29 実験手法 ELECTRON MICROSCOPY (3.21 Å) 主引用文献 How IGF-II Binds to the Human Type 1 Insulin-like Growth Factor Receptor. Structure, 28, 2020
7BW7	Cryo-EM Structure for the Ectodomain of the Full-length Human Insulin Receptor in Complex with 1 Insulin. 分子名称: Insulin fusion, Insulin receptor 著者 Yu, D, Zhang, X, Sun, J, Li, X, Wu, Z, Han, X, Fan, C, Ma, Y, Ouyang, Q, Wang, T. 登録日 2020-04-13 公開日 2021-04-14 実験手法 ELECTRON MICROSCOPY (4.1 Å) 主引用文献 Insulin Binding Induced the Ectodomain Conformational Dynamics in the Full-length Human Insulin Receptor To Be Published
7BW8	Cryo-EM Structure for the Insulin Binding Region in the Ectodomain of the Full-length Human Insulin Receptor in Complex with 1 Insulin 分子名称: Insulin fusion, Insulin receptor 著者 Yu, D, Zhang, X, Sun, J, Li, X, Wu, Z, Han, X, Fan, C, Ma, Y, Ouyang, Q, Wang, T. 登録日 2020-04-14 公開日 2021-04-14 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 Insulin Binding Induced the Ectodomain Conformational Dynamics in the Full-length Human Insulin Receptor To Be Published
7BWA	Cryo-EM Structure for the Ectodomain of the Full-length Human Insulin Receptor in Complex with 2 Insulin 分子名称: Insulin fusion, Insulin receptor 著者 Yu, D, Zhang, X, Sun, J, Li, X, Wu, Z, Han, X, Fan, C, Ma, Y, Ouyang, Q, Wang, T. 登録日 2020-04-14 公開日 2021-04-14 実験手法 ELECTRON MICROSCOPY (4.9 Å) 主引用文献 Insulin Binding Induced the Ectodomain Conformational Dynamics in the Full-length Human Insulin Receptor To Be Published
6X4X	B24Y DKP insulin 分子名称: Insulin, Insulin chain A 著者 Weiss, M.A, Yang, Y. 登録日 2020-05-24 公開日 2020-08-05 最終更新日 2023-06-14 実験手法 SOLUTION NMR 主引用文献 Evolution of insulin at the edge of foldability and its medical implications. Proc.Natl.Acad.Sci.USA, 117, 2020
6Z7Y	Human insulin in complex with the analytical antibody OXI-005 Fab 分子名称: Insulin, OXI-005 Fab Heavy chain, OXI-005 Fab Light chain 著者 Johansson, E. 登録日 2020-06-02 公開日 2020-12-30 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Insulin binding to the analytical antibody sandwich pair OXI-005 and HUI-018: Epitope mapping and binding properties. Protein Sci., 30, 2021
6Z7Z	Porcine insulin in complex with the analytical antibody OXI-005 Fab 分子名称: Insulin, MAGNESIUM ION, OXI-005 Fab Heavy chain, ... 著者 Johansson, E. 登録日 2020-06-02 公開日 2020-12-30 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Insulin binding to the analytical antibody sandwich pair OXI-005 and HUI-018: Epitope mapping and binding properties. Protein Sci., 30, 2021
6Z7W	Human insulin in complex with the analytical antibody HUI-018 Fab 分子名称: HUI-018 Fab Heavy Chain, Insulin, MAb 6H10 light chain 著者 Johansson, E. 登録日 2020-06-02 公開日 2020-12-30 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.42 Å) 主引用文献 Insulin binding to the analytical antibody sandwich pair OXI-005 and HUI-018: Epitope mapping and binding properties. Protein Sci., 30, 2021
6ZHB	3D electron diffraction structure of bovine insulin 分子名称: Insulin, ZINC ION 著者 Blum, T, Housset, D, Clabbers, M.T.B, van Genderen, E, Bacia-Verloop, M, Zander, U, McCarthy, A.A, Schoehn, G, Ling, W.L, Abrahams, J.P. 登録日 2020-06-22 公開日 2021-01-27 最終更新日 2024-01-24 実験手法 ELECTRON CRYSTALLOGRAPHY (3.25 Å) 主引用文献 Statistically correcting dynamical electron scattering improves the refinement of protein nanocrystals, including charge refinement of coordinated metals. Acta Crystallogr D Struct Biol, 77, 2021

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